Prevention of Syncope Trial (POST) : A randomized, placebo-controlled study of metoprolol in the prevention of vasovagal syncope
Previous studies that assessed the effects of beta-blockers in preventing vasovagal syncope provided mixed results. Our goal was to determine whether treatment with metoprolol reduces the risk of syncope in patients with vasovagal syncope. The multicenter Prevention of Syncope Trial (POST) was a ran...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2006-03, Vol.113 (9), p.1164-1170 |
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| creator | SHELDON, Robert CONNOLLY, Stuart KOSHMAN, Mary-Lou ROSE, Sarah KLINGENHEBEN, Thomas KRAHN, Andrew MORILLO, Carlos TALAJIC, Mario KU, Teresa FOUAD-TARAZI, Fetnat RITCHIE, Debbie |
| description | Previous studies that assessed the effects of beta-blockers in preventing vasovagal syncope provided mixed results. Our goal was to determine whether treatment with metoprolol reduces the risk of syncope in patients with vasovagal syncope.
The multicenter Prevention of Syncope Trial (POST) was a randomized, placebo-controlled, double-blind, trial designed to assess the effects of metoprolol in vasovagal syncope over a 1-year treatment period. Two prespecified analyses included the relationships of age and initial tilt-test results to any benefit from metoprolol. All patients had >2 syncopal spells and a positive tilt test. Randomization was stratified according to ages or =42 years. Patients received either metoprolol or matching placebo at highest-tolerated doses from 25 to 200 mg daily. The main outcome measure was the first recurrence of syncope. A total of 208 patients (mean age 42+/-18 years) with a median of 9 syncopal spells over a median of 11 years were randomized, 108 to receive metoprolol and 100 to the placebo group. There were 75 patients with > or =1 recurrence of syncope. The likelihood of recurrent syncope was not significantly different between groups. Neither the age of the patient nor the need for isoproterenol to produce a positive tilt test predicted subsequent significant benefit from metoprolol.
Metoprolol was not effective in preventing vasovagal syncope in the study population. |
| doi_str_mv | 10.1161/CIRCULATIONAHA.105.535161 |
| format | Article |
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The multicenter Prevention of Syncope Trial (POST) was a randomized, placebo-controlled, double-blind, trial designed to assess the effects of metoprolol in vasovagal syncope over a 1-year treatment period. Two prespecified analyses included the relationships of age and initial tilt-test results to any benefit from metoprolol. All patients had >2 syncopal spells and a positive tilt test. Randomization was stratified according to ages <42 and > or =42 years. Patients received either metoprolol or matching placebo at highest-tolerated doses from 25 to 200 mg daily. The main outcome measure was the first recurrence of syncope. A total of 208 patients (mean age 42+/-18 years) with a median of 9 syncopal spells over a median of 11 years were randomized, 108 to receive metoprolol and 100 to the placebo group. There were 75 patients with > or =1 recurrence of syncope. The likelihood of recurrent syncope was not significantly different between groups. Neither the age of the patient nor the need for isoproterenol to produce a positive tilt test predicted subsequent significant benefit from metoprolol.
Metoprolol was not effective in preventing vasovagal syncope in the study population.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/CIRCULATIONAHA.105.535161</identifier><identifier>PMID: 16505178</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adrenergic beta-Antagonists - therapeutic use ; Adult ; Age Factors ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular system ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Double-Blind Method ; Female ; Humans ; Incidence ; Male ; Maximum Tolerated Dose ; Medical sciences ; Metoprolol - administration & dosage ; Middle Aged ; Pharmacology. Drug treatments ; Placebos ; Recurrence ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Syncope, Vasovagal - drug therapy ; Syncope, Vasovagal - prevention & control ; Tilt-Table Test ; Treatment Failure ; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels ; Vasodilator agents. Cerebral vasodilators</subject><ispartof>Circulation (New York, N.Y.), 2006-03, Vol.113 (9), p.1164-1170</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-60d3ae51c6551c7a2a2fbbb2a6a59057a7a2a7016e5a1a9db7c636169347d71d3</citedby><cites>FETCH-LOGICAL-c387t-60d3ae51c6551c7a2a2fbbb2a6a59057a7a2a7016e5a1a9db7c636169347d71d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3674,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17592174$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16505178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHELDON, Robert</creatorcontrib><creatorcontrib>CONNOLLY, Stuart</creatorcontrib><creatorcontrib>KOSHMAN, Mary-Lou</creatorcontrib><creatorcontrib>ROSE, Sarah</creatorcontrib><creatorcontrib>KLINGENHEBEN, Thomas</creatorcontrib><creatorcontrib>KRAHN, Andrew</creatorcontrib><creatorcontrib>MORILLO, Carlos</creatorcontrib><creatorcontrib>TALAJIC, Mario</creatorcontrib><creatorcontrib>KU, Teresa</creatorcontrib><creatorcontrib>FOUAD-TARAZI, Fetnat</creatorcontrib><creatorcontrib>RITCHIE, Debbie</creatorcontrib><creatorcontrib>POST Investigators</creatorcontrib><title>Prevention of Syncope Trial (POST) : A randomized, placebo-controlled study of metoprolol in the prevention of vasovagal syncope</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Previous studies that assessed the effects of beta-blockers in preventing vasovagal syncope provided mixed results. Our goal was to determine whether treatment with metoprolol reduces the risk of syncope in patients with vasovagal syncope.
The multicenter Prevention of Syncope Trial (POST) was a randomized, placebo-controlled, double-blind, trial designed to assess the effects of metoprolol in vasovagal syncope over a 1-year treatment period. Two prespecified analyses included the relationships of age and initial tilt-test results to any benefit from metoprolol. All patients had >2 syncopal spells and a positive tilt test. Randomization was stratified according to ages <42 and > or =42 years. Patients received either metoprolol or matching placebo at highest-tolerated doses from 25 to 200 mg daily. The main outcome measure was the first recurrence of syncope. A total of 208 patients (mean age 42+/-18 years) with a median of 9 syncopal spells over a median of 11 years were randomized, 108 to receive metoprolol and 100 to the placebo group. There were 75 patients with > or =1 recurrence of syncope. The likelihood of recurrent syncope was not significantly different between groups. Neither the age of the patient nor the need for isoproterenol to produce a positive tilt test predicted subsequent significant benefit from metoprolol.
Metoprolol was not effective in preventing vasovagal syncope in the study population.</description><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular system</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Maximum Tolerated Dose</subject><subject>Medical sciences</subject><subject>Metoprolol - administration & dosage</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Placebos</subject><subject>Recurrence</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Syncope, Vasovagal - drug therapy</subject><subject>Syncope, Vasovagal - prevention & control</subject><subject>Tilt-Table Test</subject><subject>Treatment Failure</subject><subject>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><subject>Vasodilator agents. Cerebral vasodilators</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkFFLwzAUhYMobk7_gsQHQcHOpFmS1bdS1A2GG257LrdJqpWuKU03mE_-dDM2GHu54Z6ccy58CN1R0qdU0Odk_JksJ_FiPP2IR3GfEt7njPufM9SlPBwEA86ic9QlhESBZGHYQVfO_fhVMMkvUYcKTjiVwy76mzVmY6q2sBW2OZ5vK2VrgxdNASV-mE3ni0f8gmPcQKXtqvg1-gnXJSiT2UDZqm1sWRqNXbvW213ByrS29qItcVHh9tvg-uTABpzdwJcvd_tT1-gih9KZm8PbQ8u310UyCibT93ESTwLFhrINBNEMDKdKcD8khBDmWZaFIIBHhEvYSZJQYThQiHQmlWCCiogNpJZUsx6K9r2qsc41Jk_rplhBs00pSXdU01OqXubpnqrP3u6z9TpbGX1MHjB6w_3BAE5BmXtaqnBHn-RRSOWA_QPlloNP</recordid><startdate>20060307</startdate><enddate>20060307</enddate><creator>SHELDON, Robert</creator><creator>CONNOLLY, Stuart</creator><creator>KOSHMAN, Mary-Lou</creator><creator>ROSE, Sarah</creator><creator>KLINGENHEBEN, Thomas</creator><creator>KRAHN, Andrew</creator><creator>MORILLO, Carlos</creator><creator>TALAJIC, Mario</creator><creator>KU, Teresa</creator><creator>FOUAD-TARAZI, Fetnat</creator><creator>RITCHIE, Debbie</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20060307</creationdate><title>Prevention of Syncope Trial (POST) : A randomized, placebo-controlled study of metoprolol in the prevention of vasovagal syncope</title><author>SHELDON, Robert ; CONNOLLY, Stuart ; KOSHMAN, Mary-Lou ; ROSE, Sarah ; KLINGENHEBEN, Thomas ; KRAHN, Andrew ; MORILLO, Carlos ; TALAJIC, Mario ; KU, Teresa ; FOUAD-TARAZI, Fetnat ; RITCHIE, Debbie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-60d3ae51c6551c7a2a2fbbb2a6a59057a7a2a7016e5a1a9db7c636169347d71d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adrenergic beta-Antagonists - therapeutic use</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular system</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Maximum Tolerated Dose</topic><topic>Medical sciences</topic><topic>Metoprolol - administration & dosage</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Placebos</topic><topic>Recurrence</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Syncope, Vasovagal - drug therapy</topic><topic>Syncope, Vasovagal - prevention & control</topic><topic>Tilt-Table Test</topic><topic>Treatment Failure</topic><topic>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</topic><topic>Vasodilator agents. Cerebral vasodilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHELDON, Robert</creatorcontrib><creatorcontrib>CONNOLLY, Stuart</creatorcontrib><creatorcontrib>KOSHMAN, Mary-Lou</creatorcontrib><creatorcontrib>ROSE, Sarah</creatorcontrib><creatorcontrib>KLINGENHEBEN, Thomas</creatorcontrib><creatorcontrib>KRAHN, Andrew</creatorcontrib><creatorcontrib>MORILLO, Carlos</creatorcontrib><creatorcontrib>TALAJIC, Mario</creatorcontrib><creatorcontrib>KU, Teresa</creatorcontrib><creatorcontrib>FOUAD-TARAZI, Fetnat</creatorcontrib><creatorcontrib>RITCHIE, Debbie</creatorcontrib><creatorcontrib>POST Investigators</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHELDON, Robert</au><au>CONNOLLY, Stuart</au><au>KOSHMAN, Mary-Lou</au><au>ROSE, Sarah</au><au>KLINGENHEBEN, Thomas</au><au>KRAHN, Andrew</au><au>MORILLO, Carlos</au><au>TALAJIC, Mario</au><au>KU, Teresa</au><au>FOUAD-TARAZI, Fetnat</au><au>RITCHIE, Debbie</au><aucorp>POST Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention of Syncope Trial (POST) : A randomized, placebo-controlled study of metoprolol in the prevention of vasovagal syncope</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2006-03-07</date><risdate>2006</risdate><volume>113</volume><issue>9</issue><spage>1164</spage><epage>1170</epage><pages>1164-1170</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Previous studies that assessed the effects of beta-blockers in preventing vasovagal syncope provided mixed results. Our goal was to determine whether treatment with metoprolol reduces the risk of syncope in patients with vasovagal syncope.
The multicenter Prevention of Syncope Trial (POST) was a randomized, placebo-controlled, double-blind, trial designed to assess the effects of metoprolol in vasovagal syncope over a 1-year treatment period. Two prespecified analyses included the relationships of age and initial tilt-test results to any benefit from metoprolol. All patients had >2 syncopal spells and a positive tilt test. Randomization was stratified according to ages <42 and > or =42 years. Patients received either metoprolol or matching placebo at highest-tolerated doses from 25 to 200 mg daily. The main outcome measure was the first recurrence of syncope. A total of 208 patients (mean age 42+/-18 years) with a median of 9 syncopal spells over a median of 11 years were randomized, 108 to receive metoprolol and 100 to the placebo group. There were 75 patients with > or =1 recurrence of syncope. The likelihood of recurrent syncope was not significantly different between groups. Neither the age of the patient nor the need for isoproterenol to produce a positive tilt test predicted subsequent significant benefit from metoprolol.
Metoprolol was not effective in preventing vasovagal syncope in the study population.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>16505178</pmid><doi>10.1161/CIRCULATIONAHA.105.535161</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 2006-03, Vol.113 (9), p.1164-1170 |
| issn | 0009-7322 1524-4539 |
| language | eng |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Adrenergic beta-Antagonists - therapeutic use Adult Age Factors Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Double-Blind Method Female Humans Incidence Male Maximum Tolerated Dose Medical sciences Metoprolol - administration & dosage Middle Aged Pharmacology. Drug treatments Placebos Recurrence Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Syncope, Vasovagal - drug therapy Syncope, Vasovagal - prevention & control Tilt-Table Test Treatment Failure Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels Vasodilator agents. Cerebral vasodilators |
| title | Prevention of Syncope Trial (POST) : A randomized, placebo-controlled study of metoprolol in the prevention of vasovagal syncope |
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