Beneficial effect of oral sildenafil therapy on childhood pulmonary arterial hypertension : Twelve-month clinical trial of a single-drug, open-label, pilot study

Pulmonary arterial hypertension (PAH) is a progressive and fatal disease. Sildenafil is a type 5 phosphodiesterase inhibitor and pulmonary vasodilator. Therefore, we hypothesized that sildenafil would improve distance walked in 6 minutes and hemodynamics in children with PAH. After baseline assessme...

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