Prostacyclin Synthase Deficiency Leads to Exacerbation or Occurrence of Endothelium-Dependent Contraction and Causes Cardiovascular Disorders Mainly via the Non-TxA 2 Prostanoids/TP Axis

Prostaglandin I synthesized by endothelial COX (cyclooxygenase) evokes potent vasodilation in some blood vessels but is paradoxically responsible for endothelium-dependent constriction (EDC) in others. Prostaglandin I production and EDC may be enhanced in diseases such as hypertension. However, how...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Circulation research 2024-08, Vol.135 (6), p.e133
Hauptverfasser:	Ge, Jiahui, Zhou, Yingbi, Li, Hui, Zeng, Ruhui, Xie, Kaiqi, Leng, Jing, Chen, Xijian, Yu, Gang, Shi, Xinya, Xu, Yineng, He, Dong, Guo, Pi, Zhou, Yongyin, Luo, Hongjun, Luo, Wenhong, Liu, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiomegaly - genetics Cardiomegaly - metabolism Cardiomegaly - physiopathology Cardiovascular Diseases - etiology Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Cardiovascular Diseases - physiopathology Cyclooxygenase 1 - deficiency Cyclooxygenase 1 - genetics Cyclooxygenase 1 - metabolism Cytochrome P-450 Enzyme System - deficiency Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Humans Intramolecular Oxidoreductases - deficiency Intramolecular Oxidoreductases - genetics Intramolecular Oxidoreductases - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Prostaglandins - metabolism Receptors, Thromboxane - genetics Receptors, Thromboxane - metabolism Signal Transduction Thromboxane A2 - metabolism Vascular Remodeling Vasoconstriction Vasodilation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!