Cellular Mechanism Underlying Hypothermia-Induced Ventricular Tachycardia/Ventricular Fibrillation in the Setting of Early Repolarization and the Protective Effect of Quinidine, Cilostazol, and Milrinone

BACKGROUND—Hypothermia has been reported to induce ventricular tachycardia and fibrillation (VT/VF) in patients with early repolarization (ER) pattern. This study examines the cellular mechanisms underlying VT/VF associated with hypothermia in an experimental model of ER syndrome and examines the ef...

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Veröffentlicht in:	Circulation. Arrhythmia and electrophysiology 2014-02, Vol.7 (1), p.134-142
Hauptverfasser:	Gurabi, Zsolt, Koncz, István, Patocskai, Bence, Nesterenko, Vladislav V, Antzelevitch, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Anti-Arrhythmia Agents - pharmacology Disease Models, Animal Dogs Electrocardiography Heart Conduction System - drug effects Heart Conduction System - physiopathology Hypothermia, Induced Milrinone - pharmacology Perfusion Phosphodiesterase 3 Inhibitors - pharmacology Quinidine - pharmacology Signal Transduction - drug effects Tachycardia, Ventricular - etiology Tachycardia, Ventricular - physiopathology Tachycardia, Ventricular - prevention & control Tetrazoles - pharmacology Time Factors Ventricular Fibrillation - etiology Ventricular Fibrillation - physiopathology Ventricular Fibrillation - prevention & control
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