Latent Genetic Backgrounds and Molecular Pathogenesis in Drug-Induced Long-QT Syndrome

BACKGROUND—Drugs with IKr-blocking action cause secondary long-QT syndrome. Several cases have been associated with mutations of genes coding cardiac ion channels, but their frequency among patients affected by drug-induced long-QT syndrome (dLQTS) and the resultant molecular effects remain unknown....

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Veröffentlicht in:	Circulation. Arrhythmia and electrophysiology 2009-10, Vol.2 (5), p.511-523
Hauptverfasser:	Itoh, Hideki, Sakaguchi, Tomoko, Ding, Wei-Guang, Watanabe, Eiichi, Watanabe, Ichiro, Nishio, Yukiko, Makiyama, Takeru, Ohno, Seiko, Akao, Masaharu, Higashi, Yukei, Zenda, Naoko, Kubota, Tomoki, Mori, Chikara, Okajima, Katsunori, Haruna, Tetsuya, Miyamoto, Akashi, Kawamura, Mihoko, Ishida, Katsuya, Nagaoka, Iori, Oka, Yuko, Nakazawa, Yuko, Yao, Takenori, Jo, Hikari, Sugimoto, Yoshihisa, Ashihara, Takashi, Hayashi, Hideki, Ito, Makoto, Imoto, Keiji, Matsuura, Hiroshi, Horie, Minoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Antiarythmic agents Biological and medical sciences Cardiac dysrhythmias Cardiology. Vascular system Cardiovascular system Computer Simulation Cricetinae DNA Mutational Analysis ERG1 Potassium Channel Ether-A-Go-Go Potassium Channels - genetics Female General aspects. Genetic counseling Genotype Heart Humans Incidence Japan - epidemiology KCNQ1 Potassium Channel - genetics Long QT Syndrome - chemically induced Long QT Syndrome - epidemiology Long QT Syndrome - genetics Long QT Syndrome - physiopathology Male Medical genetics Medical sciences Middle Aged Muscle Proteins - genetics Mutation, Missense NAV1.5 Voltage-Gated Sodium Channel Pharmacology. Drug treatments Risk Factors Sodium Channels - genetics Transfection
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