Endothelial HMGB1 Is a Critical Regulator of LDL Transcytosis via an SREBP2–SR-BI Axis

OBJECTIVE:LDL (low-density lipoprotein) transcytosis across the endothelium is performed by the SR-BI (scavenger receptor class B type 1) receptor and contributes to atherosclerosis. HMGB1 (high mobility group box 1) is a structural protein in the nucleus that is released by cells during inflammatio...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2021-01, Vol.41 (1), p.200-216
Hauptverfasser:	Ghaffari, Siavash, Jang, Erika, Naderinabi, Farnoosh, Sanwal, Rajiv, Khosraviani, Negar, Wang, Changsen, Steinberg, Benjamin E., Goldenberg, Neil M., Ikeda, Jiro, Lee, Warren L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Atherosclerosis - prevention & control Cardiovascular System & Cardiology Cells, Cultured Disease Models, Animal Endothelial Cells - metabolism Female Hematology HMGB1 Protein - deficiency HMGB1 Protein - genetics HMGB1 Protein - metabolism Humans Life Sciences & Biomedicine Male Mice Mice, Inbred C57BL Mice, Knockout Peripheral Vascular Disease Protein Stability Receptors, LDL - genetics Receptors, LDL - metabolism Scavenger Receptors, Class B - genetics Scavenger Receptors, Class B - metabolism Science & Technology Signal Transduction Sterol Regulatory Element Binding Protein 2 - genetics Sterol Regulatory Element Binding Protein 2 - metabolism Transcytosis
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