Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47 phox in Vascular Smooth Muscle Cells

Objective- PDI (protein disulfide isomerase A1) was reported to support Nox1 (NADPH oxidase) activation mediated by growth factors in vascular smooth muscle cells. Our aim was to investigate the molecular mechanism by which PDI activates Nox1 and the functional implications of PDI in Nox1 activation...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2019-02, Vol.39 (2), p.224-236
Hauptverfasser:	Gimenez, Marcela, Veríssimo-Filho, Sidney, Wittig, Ilka, Schickling, Brandon M, Hahner, Fabian, Schürmann, Christoph, Netto, Luis E S, Rosa, José César, Brandes, Ralf P, Sartoretto, Simone, De Lucca Camargo, Lívia, Abdulkader, Fernando, Miller, Jr, Francis J, Lopes, Lucia Rossetti
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Movement Cells, Cultured Disulfides - chemistry Enzyme Activation Humans Male Mice Mice, Inbred C57BL Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - metabolism NADPH Oxidase 1 - metabolism NADPH Oxidases - chemistry Oxidation-Reduction Protein Disulfide-Isomerases - chemistry Superoxides - metabolism
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