Angiotensin-Converting Enzyme 2 Decreases Formation and Severity of Angiotensin II–Induced Abdominal Aortic Aneurysms

OBJECTIVE—Angiotensin-converting enzyme 2 (ACE2) cleaves angiotensin II (AngII) to form angiotensin-(1–7) (Ang-(1–7)), which generally opposes effects of AngII. AngII infusion into hypercholesterolemic male mice induces formation of abdominal aortic aneurysms (AAAs). This study tests the hypothesis...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2014-12, Vol.34 (12), p.2617-2623
Hauptverfasser:	Thatcher, Sean E, Zhang, Xuan, Howatt, Deborah A, Yiannikouris, Frederique, Gurley, Susan B, Ennis, Terri, Curci, John A, Daugherty, Alan, Cassis, Lisa A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angiotensin II - metabolism Animals Aortic Aneurysm, Abdominal - etiology Aortic Aneurysm, Abdominal - metabolism Aortic Aneurysm, Abdominal - pathology Diminazene - analogs & derivatives Diminazene - pharmacology Disease Models, Animal Enzyme Activation - drug effects Female Humans Hypercholesterolemia - complications Hypercholesterolemia - metabolism Leukocytes - enzymology Male Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Peptidyl-Dipeptidase A - deficiency Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Receptors, LDL - deficiency Receptors, LDL - genetics Renin-Angiotensin System RNA, Messenger - genetics RNA, Messenger - metabolism
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