Pyripyropene A, an Acyl–Coenzyme A: Cholesterol Acyltransferase 2–Selective Inhibitor, Attenuates Hypercholesterolemia and Atherosclerosis in Murine Models of Hyperlipidemia

OBJECTIVE—Pyripyropene A (PPPA) of fungal origin is the first compound that has been found to strongly and selectively inhibit acyl–coenzyme A:cholesterol acyltransferase 2 (ACAT2) isozyme activity in vitro. The purpose of the present study was to investigate in vivo efficacy of the ACAT2-selective...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2011-05, Vol.31 (5), p.1108-1115
Hauptverfasser:	Ohshiro, Taichi, Matsuda, Daisuke, Sakai, Kent, Degirolamo, Chiara, Yagyu, Hiroaki, Rudel, Lawrence L, Ōmura, Satoshi, Ishibashi, Shun, Tomoda, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Anticholesteremic Agents - pharmacology Apolipoproteins E - deficiency Apolipoproteins E - genetics Atherosclerosis (general aspects, experimental research) Atherosclerosis - enzymology Atherosclerosis - genetics Atherosclerosis - pathology Atherosclerosis - prevention & control Biological and medical sciences Blood and lymphatic vessels Blood. Blood coagulation. Reticuloendothelial system Cardiology. Vascular system Cholesterol Esters - metabolism Cholesterol, Dietary - blood Disease Models, Animal Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Hypercholesterolemia - enzymology Hypercholesterolemia - genetics Hypercholesterolemia - pathology Hypercholesterolemia - prevention & control Intestinal Absorption - drug effects Intestines - drug effects Intestines - enzymology Lipoproteins, LDL - blood Lipoproteins, VLDL - blood Liver - drug effects Liver - enzymology Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Pharmacology. Drug treatments Pyridines - pharmacology Sesquiterpenes - pharmacology Sterol O-Acyltransferase - antagonists & inhibitors Sterol O-Acyltransferase - metabolism Sterol O-Acyltransferase 2 Time Factors
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