Chronic Hypoxia Activates the Akt and β-Catenin Pathways in Human Macrophages

OBJECTIVE—Macrophage activation contributes importantly to the pathogenesis of inflammatory diseases including atherosclerosis. Macrophages exist chronically under moderate hypoxia (2% to 5% O2) in inflamed tissues such as atherosclerotic plaques. However, macrophage phenotypes in such environments...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2009-10, Vol.29 (10), p.1664-1670
Hauptverfasser:	Deguchi, Jun-o, Yamazaki, Hiroyuki, Aikawa, Elena, Aikawa, Masanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Atherosclerosis (general aspects, experimental research) Atherosclerosis - metabolism beta Catenin - physiology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Cell Hypoxia Cell Nucleus - metabolism Cells, Cultured Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Humans Hyaluronan Receptors - analysis Lipoproteins, LDL - toxicity Macrophage Activation Macrophages - metabolism Matrix Metalloproteinase 7 - analysis Matrix Metalloproteinase 7 - genetics Matrix Metalloproteinase 7 - physiology Medical sciences Pharmacology. Drug treatments Phosphorylation Proto-Oncogene Proteins c-akt - physiology Signal Transduction - physiology Vascular wall
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