Clones of Interstitial Cells From Bovine Aortic Valve Exhibit Different Calcifying Potential When Exposed to Endotoxin and Phosphate

OBJECTIVE—Our purpose was to study in vitro whether phenotypically-distinct interstitial cell clones from bovine aortic valve (BVIC) possess different calcifying potential in response to endotoxin (lipopolysaccharide [LPS]) and phosphate (Pi). METHODS AND RESULTS—Among various clones of BVIC obtaine...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2008-12, Vol.28 (12), p.2165-2172
Hauptverfasser:	Rattazzi, Marcello, Iop, Laura, Faggin, Elisabetta, Bertacco, Elisa, Zoppellaro, Giacomo, Baesso, Ilenia, Puato, Massimo, Torregrossa, Gianluca, Fadini, Gian Paolo, Agostini, Carlo, Gerosa, Gino, Sartore, Saverio, Pauletto, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism Animals Aortic Valve - drug effects Aortic Valve - metabolism Aortic Valve - pathology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Calcinosis - etiology Calcinosis - metabolism Calcinosis - pathology Calcium - metabolism Cardiology. Vascular system Cattle Clone Cells Coculture Techniques Diseases of the aorta Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Heart Valve Diseases - etiology Heart Valve Diseases - metabolism Heart Valve Diseases - pathology Lipopolysaccharides - toxicity Medical sciences Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Phenotype Phosphates - toxicity
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