Neutralisation of the anti-coagulant effects of heparin by histones in blood plasma and purified systems

Summary Neutrophil extracellular traps (NETs) composed primarily of DNA and histones are a link between infection, inflammation and coagulation. NETs promote coagulation and approaches to destabilise NETs have been explored to reduce thrombosis and treat sepsis. Heparinoids bind histones and we repo...

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Veröffentlicht in:	Thrombosis and haemostasis 2016-03, Vol.115 (3), p.591-599
Hauptverfasser:	Longstaff, Colin, Hogwood, John, Gray, Elaine, Komorowicz, Erzsébet, Varjú, Imre, Varga, Zoltán, Kolev, Krasimir
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants - chemistry Antithrombins - chemistry Blood Coagulation Coagulants - chemistry Coagulation and Fibrinolysis DNA - chemistry Elasticity Fibrin - chemistry Hemostasis Heparin - blood Heparin - chemistry Heparin, Low-Molecular-Weight - chemistry Histones - blood Histones - chemistry Humans Inhibitory Concentration 50 Partial Thromboplastin Time Plasma - chemistry Protein Binding Sepsis - therapy Surface Plasmon Resonance Thrombosis - blood Viscosity
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