Effect of aspirin intake at bedtime versus on awakening on circadian rhythm of platelet reactivity: A randomised cross-over trial

The risk of acute cardiovascular events is highest during morning hours, and platelet activity peaks during morning hours. The effect of timing of aspirin intake on circadian rhythm and morning peak of platelet reactivity is not known. It was our objective to evaluate the effect of timing of aspirin...

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Veröffentlicht in:	Thrombosis and haemostasis 2014-12, Vol.112 (6), p.1209-1218
Hauptverfasser:	BONTEN, Tobias N, SARIS, Anno, VAN OOSTROM, Monique J, SNOEP, Jaapjan D, ROSENDAAL, Frits R, ZWAGINGA, Jaap J, EIKENBOOM, Jeroen, VAN DER MEER, Pieter F, VAN DER BOM, Johanna G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspirin - administration & dosage Biological and medical sciences Biomarkers - blood Blood coagulation. Blood cells Blood Platelets - drug effects Blood Platelets - metabolism Circadian Rhythm Cross-Over Studies Cyclooxygenase 1 - blood Drug Administration Schedule Female Fundamental and applied biological sciences. Psychology Healthy Volunteers Hematologic and hematopoietic diseases Humans Male Medical sciences Molecular and cellular biology Netherlands P-Selectin - blood Platelet Activation - drug effects Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - administration & dosage Platelet diseases and coagulopathies Platelet Function Tests Prospective Studies Thromboxane B2 - blood Time Factors Treatment Outcome Young Adult
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