Targeted intracellular accumulation of macrophage migration inhibitory factor in the reperfused heart mediates cardioprotection

Summary S -nitrosation of macrophage migration inhibitory factor (MIF) has been shown to be cytoprotective in myocardial ischaemia/reperfusion (I/R) injury. Since the exact mechanism of action is unknown, we here characterise the cardioprotective effects of targeted intracellular accumulation of MIF...

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Veröffentlicht in:	Thrombosis and haemostasis 2016-01, Vol.115 (1), p.200-212
Hauptverfasser:	Pohl, Julia, Hendgen-Cotta, Ulrike R., Rammos, Christos, Luedike, Peter, Mull, Elena, Stoppe, Christian, Jülicher, Karen, Lue, Hongqi, Merx, Marc, Kelm, Malte, Bernhagen, Jürgen, Rassaf, Tienush
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitate Hydratase - metabolism Animals Atherosclerosis and Ischaemic Disease Cell Line Disease Models, Animal Hydrogen Peroxide - metabolism Intramolecular Oxidoreductases - deficiency Intramolecular Oxidoreductases - genetics Intramolecular Oxidoreductases - metabolism Macrophage Migration-Inhibitory Factors - deficiency Macrophage Migration-Inhibitory Factors - genetics Macrophage Migration-Inhibitory Factors - metabolism Male Mice, Inbred C57BL Mice, Knockout Myocardial Infarction - genetics Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - prevention & control Myocardial Reperfusion Injury - genetics Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Nitrosation Oxidative Stress Protein Processing, Post-Translational Time Factors
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