Alternation of histone and DNA methylation in human atherosclerotic carotid plaques

Summary Little is known about epigenetics and its possible role in atherosclerosis. We here analysed histone and DNA methylation and the expression of corresponding methyltransferases in early and advanced human atherosclerotic carotid lesions in comparison to healthy carotid arteries. Western Blott...

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Veröffentlicht in:	Thrombosis and haemostasis 2015-08, Vol.113 (2), p.390-402
Hauptverfasser:	Greißel, Anna, Culmes, Mihaela, Napieralski, Rudolf, Wagner, Ernst, Gebhard, Harry, Schmitt, Manfred, Zimmermann, Alexander, Eckstein, Hans-Henning, Zernecke, Alma, Pelisek, Jaroslav
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Blood Cells - metabolism Carotid Arteries - metabolism Carotid Artery Diseases - genetics Carotid Artery Diseases - metabolism Cellular Signalling and Proteolysis Disease Progression DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methylation DNA-Binding Proteins - metabolism Enzyme Induction Female Histocompatibility Antigens - metabolism Histone-Lysine N-Methyltransferase - metabolism Humans Inflammation Leukocytes - metabolism Long Interspersed Nucleotide Elements Lysine - metabolism Macrophages - metabolism Male Methylation Middle Aged Mixed Function Oxygenases Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - metabolism Neoplasm Proteins - metabolism Plaque, Atherosclerotic - genetics Plaque, Atherosclerotic - metabolism Protein Processing, Post-Translational Proto-Oncogene Proteins - metabolism Real-Time Polymerase Chain Reaction
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