Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II

Summary Matriptase is a type-II transmembrane serine protease involved in epithelial homeostasis in both health and disease, and is implicated in the development and progression of a variety of cancers. Matriptase mediates its biological effects both via as yet undefined substrates and pathways, and...

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Veröffentlicht in:	Thrombosis and haemostasis 2014, Vol.111 (8), p.402-411
Hauptverfasser:	Gray, Kelly, Elghadban, Salma, Thongyoo, Panumart, Owen, Kate A., Szabo, Roman, Bugge, Thomas H., Tate, Edward W., Leatherbarrow, Robin J., Ellis, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood coagulation. Blood cells Cell Line, Tumor Cell Movement - drug effects Cellular Proteolysis and Oncology Cyclotides - pharmacology Dogs Electric Impedance Fundamental and applied biological sciences. Psychology HEK293 Cells Hematologic and hematopoietic diseases Hepatocyte Growth Factor - metabolism Humans Madin Darby Canine Kidney Cells Male Medical sciences Molecular and cellular biology Molecular Targeted Therapy Neoplasm Invasiveness Platelet diseases and coagulopathies Prostatic Neoplasms - enzymology Prostatic Neoplasms - pathology Protein Precursors - metabolism Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Serine Proteinase Inhibitors - pharmacology Substrate Specificity Tight Junctions - drug effects Tight Junctions - enzymology Time Factors Transfection
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