P2X1-initiated p38 signalling enhances thromboxane A2-induced platelet secretion and aggregation

Summary ATP released by activated platelets can serve as a positive feedback machinery to amplify platelet responses by activating P2X 1 receptors. It has, however, not been defined how P2X 1 activities influence thromboxane A 2 (TXA 2 )-stimulated platelet functional responses. Our aim was to elabo...

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Veröffentlicht in:	Thrombosis and haemostasis 2014, Vol.111 (1), p.142-150
Hauptverfasser:	Huang, Zhangsen, Liu, Pu, Zhu, Linjing, Li, Nailin, Hu, Hu
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology Adult Benzenesulfonates - pharmacology Biological and medical sciences Blood coagulation. Blood cells Blood Platelets - drug effects Blood Platelets - physiology Cell Degranulation - drug effects Cells, Cultured Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Hematologic and hematopoietic diseases Humans Imidazoles - pharmacology Male MAP Kinase Signaling System - drug effects Medical sciences Medicin och hälsovetenskap Molecular and cellular biology P-Selectin - genetics P-Selectin - metabolism p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Phosphorylation - drug effects Platelet Aggregation - drug effects Platelet diseases and coagulopathies Platelets and Blood Cells Purinergic P2X Receptor Antagonists - pharmacology Pyridines - pharmacology Receptors, Purinergic P2X1 - metabolism Thromboxane A2 - metabolism Young Adult
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