Protease activated receptor 4 limits bacterial growth and lung pathology during late stage Streptococcus pneumoniae induced pneumonia in mice

Summary Streptococcus pneumoniae is a common causative pathogen of pneumonia and sepsis. Pneumonia and sepsis are associated with enhanced activation of coagulation, resulting in the production of several host-derived proteases at the primary site of infection and in the circulation. Serine protease...

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Veröffentlicht in:	Thrombosis and haemostasis 2013-09, Vol.109 (3), p.582-592
Hauptverfasser:	de Stoppelaar, Sacha F., van ’t Veer, Cornelis, van den Boogaard, Florry E., Nieuwland, Rienk, Hoogendijk, Arie J., de Boer, Onno J., Roelofs, Joris J. T. H., der Poll, Tom van
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood coagulation. Blood cells Blood Platelets - metabolism Cytokines - metabolism Disease Models, Animal Fundamental and applied biological sciences. Psychology Hematologic and hematopoietic diseases Humans Inflammation Liver - microbiology Lung - microbiology Lung - pathology Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Molecular and cellular biology Peptides - chemistry Platelet diseases and coagulopathies Pneumonia, Pneumococcal - metabolism Pneumonia, Pneumococcal - microbiology Pneumonia, Pneumococcal - pathology Receptors, Thrombin - metabolism Sepsis - metabolism Spleen - microbiology Stem Cells Streptococcus pneumoniae - growth & development Time Factors Wound Healing and Inflammation/Infection
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