Invasion mechanisms of Gram-positive pathogenic cocci
Gram-positive cocci are important human pathogens. Streptococci and staphylococci in particular are a major threat to human health,since they cause a variety of serious invasive infections. Their invasion into normally sterile sites of the host depends on elaborated bacterial mechanisms that involve...
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| Veröffentlicht in: | Thrombosis and haemostasis 2007-09, Vol.98 (3), p.488-496 |
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| container_title | Thrombosis and haemostasis |
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| creator | Nitsche-Schmitz, Patric D. Rohde, Manfred Chhatwal, Gursharan S. |
| description | Gram-positive cocci are important human pathogens. Streptococci and staphylococci in particular are a major threat to human health,since they cause a variety of serious invasive infections. Their invasion into normally sterile sites of the host depends on elaborated bacterial mechanisms that involve adhesion to the host tissue, its degradation, internalisation by host cells, and passage through epithelia and endothelia. Interactions of bacterial surface proteins with proteins of the host’s extracellular matrix as well as with cell surface receptors are crucial factors in these processes, and some of the key mechanisms are similar in many pathogenic Gram-positive cocci.Therapies that interfere with these mechanisms may become efficient alternatives to today’s antibiotic treatments. |
| doi_str_mv | 10.1160/TH07-03-0179 |
| format | Article |
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Interactions of bacterial surface proteins with proteins of the host’s extracellular matrix as well as with cell surface receptors are crucial factors in these processes, and some of the key mechanisms are similar in many pathogenic Gram-positive cocci.Therapies that interfere with these mechanisms may become efficient alternatives to today’s antibiotic treatments.</description><identifier>ISSN: 0340-6245</identifier><identifier>EISSN: 2567-689X</identifier><identifier>DOI: 10.1160/TH07-03-0179</identifier><identifier>PMID: 17849036</identifier><identifier>CODEN: THHADQ</identifier><language>eng</language><publisher>Stuttgart: Schattauer Verlag für Medizin und Naturwissenschaften</publisher><subject>Adhesins, Bacterial - metabolism ; Animals ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Antigens, Bacterial - metabolism ; Bacterial Adhesion - drug effects ; Bacterial Outer Membrane Proteins - metabolism ; Bacterial Proteins - metabolism ; Bacterial Translocation - drug effects ; Biological and medical sciences ; Blood coagulation. Blood cells ; Carrier Proteins - metabolism ; Caveolae - metabolism ; Caveolae - microbiology ; Endocytosis ; Extracellular Matrix Proteins - metabolism ; Fundamental and applied biological sciences. 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Streptococci and staphylococci in particular are a major threat to human health,since they cause a variety of serious invasive infections. Their invasion into normally sterile sites of the host depends on elaborated bacterial mechanisms that involve adhesion to the host tissue, its degradation, internalisation by host cells, and passage through epithelia and endothelia. 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Blood cells</subject><subject>Carrier Proteins - metabolism</subject><subject>Caveolae - metabolism</subject><subject>Caveolae - microbiology</subject><subject>Endocytosis</subject><subject>Extracellular Matrix Proteins - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Hydrolases - metabolism</subject><subject>internalisation</subject><subject>invasion</subject><subject>Medical sciences</subject><subject>Molecular and cellular biology</subject><subject>pathogenesis</subject><subject>Phagocytes - metabolism</subject><subject>Phagocytes - microbiology</subject><subject>Phagocytosis</subject><subject>Platelet diseases and coagulopathies</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcal Infections - metabolism</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcus</subject><subject>Staphylococcus - drug effects</subject><subject>Staphylococcus - enzymology</subject><subject>Staphylococcus - pathogenicity</subject><subject>Streptococcal Infections - drug therapy</subject><subject>Streptococcal Infections - metabolism</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcus</subject><subject>Streptococcus - drug effects</subject><subject>Streptococcus - enzymology</subject><subject>Streptococcus - pathogenicity</subject><subject>Theme Issue Article</subject><issn>0340-6245</issn><issn>2567-689X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNq1kU2L1TAUQIMoznN051q60c1YvWnaJF3K4HzAgJsR3IU0TW2GJqm56Yj_3jzewxHBna7CJYd7yAkhLym8o5TD-9srEDWwGqjoH5Fd03FRc9l_eUx2wFqoedN2J-QZ4h0A5W3fPSUnVMi2B8Z3pLsO9xpdDJW3ZtbBoccqTtVl0r5eI7rs7m216jzHrzY4U5lojHtOnkx6QfvieJ6Szxcfb8-v6ptPl9fnH25qIzqaaz6MDDRrpR2p4MKwkZeJ6n5gdDC2ay2XehTNxIduAAG0maCHFqAXchxhYKfkzWHvmuK3zWJW3qGxy6KDjRsqLhtBqewL-PYAmhQRk53UmpzX6YeioPaZ1D6TAqb2mQr-6rh3G7wdH-BjlwK8PgIajV6mpINx-MAVqJcdK9zZgcuzs96qu7ilUIr8TesONJbUOevNpl8r85yiH0pwVDqMatbWR8x6P5sYsg25XCQzl-9QDnGzSrSgvA4bmuTWrGQnW4Vz_K7m7JfiMv_Qhas1Ti9_-orF_3_Lb6_6CdlB-UA</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Nitsche-Schmitz, Patric D.</creator><creator>Rohde, Manfred</creator><creator>Chhatwal, Gursharan S.</creator><general>Schattauer Verlag für Medizin und Naturwissenschaften</general><general>Schattauer GmbH</general><general>Schattauer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070901</creationdate><title>Invasion mechanisms of Gram-positive pathogenic cocci</title><author>Nitsche-Schmitz, Patric D. ; Rohde, Manfred ; Chhatwal, Gursharan S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c751t-6bd30a348ed1767c3d6a341a9b31bce54e68ad72f6b5b07012f090400978dd0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adhesins, Bacterial - metabolism</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antigens, Bacterial - metabolism</topic><topic>Bacterial Adhesion - drug effects</topic><topic>Bacterial Outer Membrane Proteins - metabolism</topic><topic>Bacterial Proteins - metabolism</topic><topic>Bacterial Translocation - drug effects</topic><topic>Biological and medical sciences</topic><topic>Blood coagulation. 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| ispartof | Thrombosis and haemostasis, 2007-09, Vol.98 (3), p.488-496 |
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| subjects | Adhesins, Bacterial - metabolism Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antigens, Bacterial - metabolism Bacterial Adhesion - drug effects Bacterial Outer Membrane Proteins - metabolism Bacterial Proteins - metabolism Bacterial Translocation - drug effects Biological and medical sciences Blood coagulation. Blood cells Carrier Proteins - metabolism Caveolae - metabolism Caveolae - microbiology Endocytosis Extracellular Matrix Proteins - metabolism Fundamental and applied biological sciences. Psychology Hematologic and hematopoietic diseases Humans Hydrolases - metabolism internalisation invasion Medical sciences Molecular and cellular biology pathogenesis Phagocytes - metabolism Phagocytes - microbiology Phagocytosis Platelet diseases and coagulopathies Staphylococcal Infections - drug therapy Staphylococcal Infections - metabolism Staphylococcal Infections - microbiology Staphylococcus Staphylococcus - drug effects Staphylococcus - enzymology Staphylococcus - pathogenicity Streptococcal Infections - drug therapy Streptococcal Infections - metabolism Streptococcal Infections - microbiology Streptococcus Streptococcus - drug effects Streptococcus - enzymology Streptococcus - pathogenicity Theme Issue Article |
| title | Invasion mechanisms of Gram-positive pathogenic cocci |
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