Establishment of the 1st International Genetic Reference Panel for Factor V Leiden, human gDNA
Summary Forty-one laboratories participated in an international collaborative study to assess the suitability of a panel of three genomic DNA samples as the 1st International Genetic Reference Panel for the Factor V Leiden (FVL) variant.The code numbers of the materials were 03/254 (FV wild type), 0...
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| Veröffentlicht in: | Thrombosis and haemostasis 2006, Vol.95 (2), p.215-219 |
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| container_title | Thrombosis and haemostasis |
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| creator | Gray, Elaine Hawkins, J. Ross Morrison, Marion Hawkins, Malcolm Byrne, Ed Kitchen, Steve Jennings, Ian Makris, Mike Preston, F. Eric Metcalfe, Paul |
| description | Summary
Forty-one laboratories participated in an international collaborative study to assess the suitability of a panel of three genomic DNA samples as the 1st International Genetic Reference Panel for the Factor V Leiden (FVL) variant.The code numbers of the materials were 03/254 (FV wild type), 03/260 (FVL homozygote) and 03/248 (FVL heterozygote).The participants evaluated the panel against their in-house controls which were known patient samples and commercial controls. In total, 859 genotype tests were carried out on the panel, with an error rate of 0.7%.The errors were not related to specific samples of the panel or to any specific techniques.The findings of this study have indicated that this panel is suitable to be used as a reference material for genotyping of factor V Leiden. It was therefore recommended that the three genomic DNA samples be established as the 1st International Genetic Reference Panel for Factor V Leiden, Human gDNA, 04/224. This recommendation was approved by the Scientific and Standardization Committee (SSC) of the ISTH (International Society on Thrombosis and Haemostasis) in June 2004 and the Expert Committee on Biological Standardization (ECBS) of theWorld Health Organization (WHO) in November 2004. |
| doi_str_mv | 10.1160/TH05-11-0767 |
| format | Article |
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Forty-one laboratories participated in an international collaborative study to assess the suitability of a panel of three genomic DNA samples as the 1st International Genetic Reference Panel for the Factor V Leiden (FVL) variant.The code numbers of the materials were 03/254 (FV wild type), 03/260 (FVL homozygote) and 03/248 (FVL heterozygote).The participants evaluated the panel against their in-house controls which were known patient samples and commercial controls. In total, 859 genotype tests were carried out on the panel, with an error rate of 0.7%.The errors were not related to specific samples of the panel or to any specific techniques.The findings of this study have indicated that this panel is suitable to be used as a reference material for genotyping of factor V Leiden. It was therefore recommended that the three genomic DNA samples be established as the 1st International Genetic Reference Panel for Factor V Leiden, Human gDNA, 04/224. This recommendation was approved by the Scientific and Standardization Committee (SSC) of the ISTH (International Society on Thrombosis and Haemostasis) in June 2004 and the Expert Committee on Biological Standardization (ECBS) of theWorld Health Organization (WHO) in November 2004.</description><identifier>ISSN: 0340-6245</identifier><identifier>EISSN: 2567-689X</identifier><identifier>DOI: 10.1160/TH05-11-0767</identifier><language>eng</language><publisher>Schattauer GmbH</publisher><subject>New Technologies, Diagnostic Tools and Drugs</subject><ispartof>Thrombosis and haemostasis, 2006, Vol.95 (2), p.215-219</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1167-58d33308470d62c10ffc655469aa7fd2728e27def94dc7a582899d44338cf87d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH05-11-0767.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1160/TH05-11-0767$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3005,4010,27900,27901,27902,54534,54535</link.rule.ids></links><search><creatorcontrib>Gray, Elaine</creatorcontrib><creatorcontrib>Hawkins, J. Ross</creatorcontrib><creatorcontrib>Morrison, Marion</creatorcontrib><creatorcontrib>Hawkins, Malcolm</creatorcontrib><creatorcontrib>Byrne, Ed</creatorcontrib><creatorcontrib>Kitchen, Steve</creatorcontrib><creatorcontrib>Jennings, Ian</creatorcontrib><creatorcontrib>Makris, Mike</creatorcontrib><creatorcontrib>Preston, F. Eric</creatorcontrib><creatorcontrib>Metcalfe, Paul</creatorcontrib><title>Establishment of the 1st International Genetic Reference Panel for Factor V Leiden, human gDNA</title><title>Thrombosis and haemostasis</title><addtitle>Thromb Haemost</addtitle><description>Summary
Forty-one laboratories participated in an international collaborative study to assess the suitability of a panel of three genomic DNA samples as the 1st International Genetic Reference Panel for the Factor V Leiden (FVL) variant.The code numbers of the materials were 03/254 (FV wild type), 03/260 (FVL homozygote) and 03/248 (FVL heterozygote).The participants evaluated the panel against their in-house controls which were known patient samples and commercial controls. In total, 859 genotype tests were carried out on the panel, with an error rate of 0.7%.The errors were not related to specific samples of the panel or to any specific techniques.The findings of this study have indicated that this panel is suitable to be used as a reference material for genotyping of factor V Leiden. It was therefore recommended that the three genomic DNA samples be established as the 1st International Genetic Reference Panel for Factor V Leiden, Human gDNA, 04/224. This recommendation was approved by the Scientific and Standardization Committee (SSC) of the ISTH (International Society on Thrombosis and Haemostasis) in June 2004 and the Expert Committee on Biological Standardization (ECBS) of theWorld Health Organization (WHO) in November 2004.</description><subject>New Technologies, Diagnostic Tools and Drugs</subject><issn>0340-6245</issn><issn>2567-689X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNptkDtPwzAUhS0EEqWw8QO8U4Od-JWxKn1JFSBUEBORsa9JqsRBsTvw75uqjEznDJ-u7vkQumX0njFJH7YrKghjhCqpztAoE1IRqYuPczSiOadEZlxcoqsYd5QyyQsxQp_zmMxXU8eqhZBw53GqALOY8Dok6INJdRdMg5cQINUWv4KHHoIF_GICNNh3PV4Ym4Z4xxuoHYQJrvatCfj78Wl6jS68aSLc_OUYvS3m29mKbJ6X69l0Q-zwuCJCuzzPqeaKOplZRr23UgguC2OUd5nKNGTKgS-4s8oInemicJznubZeK5eP0eR01_ZdjD348qevW9P_loyWRzfl0c3QyqObAb874amqoYVy1-2HqU38nz4Arw9jTw</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Gray, Elaine</creator><creator>Hawkins, J. Ross</creator><creator>Morrison, Marion</creator><creator>Hawkins, Malcolm</creator><creator>Byrne, Ed</creator><creator>Kitchen, Steve</creator><creator>Jennings, Ian</creator><creator>Makris, Mike</creator><creator>Preston, F. Eric</creator><creator>Metcalfe, Paul</creator><general>Schattauer GmbH</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2006</creationdate><title>Establishment of the 1st International Genetic Reference Panel for Factor V Leiden, human gDNA</title><author>Gray, Elaine ; Hawkins, J. Ross ; Morrison, Marion ; Hawkins, Malcolm ; Byrne, Ed ; Kitchen, Steve ; Jennings, Ian ; Makris, Mike ; Preston, F. Eric ; Metcalfe, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1167-58d33308470d62c10ffc655469aa7fd2728e27def94dc7a582899d44338cf87d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>New Technologies, Diagnostic Tools and Drugs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gray, Elaine</creatorcontrib><creatorcontrib>Hawkins, J. Ross</creatorcontrib><creatorcontrib>Morrison, Marion</creatorcontrib><creatorcontrib>Hawkins, Malcolm</creatorcontrib><creatorcontrib>Byrne, Ed</creatorcontrib><creatorcontrib>Kitchen, Steve</creatorcontrib><creatorcontrib>Jennings, Ian</creatorcontrib><creatorcontrib>Makris, Mike</creatorcontrib><creatorcontrib>Preston, F. Eric</creatorcontrib><creatorcontrib>Metcalfe, Paul</creatorcontrib><collection>CrossRef</collection><jtitle>Thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gray, Elaine</au><au>Hawkins, J. Ross</au><au>Morrison, Marion</au><au>Hawkins, Malcolm</au><au>Byrne, Ed</au><au>Kitchen, Steve</au><au>Jennings, Ian</au><au>Makris, Mike</au><au>Preston, F. Eric</au><au>Metcalfe, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Establishment of the 1st International Genetic Reference Panel for Factor V Leiden, human gDNA</atitle><jtitle>Thrombosis and haemostasis</jtitle><addtitle>Thromb Haemost</addtitle><date>2006</date><risdate>2006</risdate><volume>95</volume><issue>2</issue><spage>215</spage><epage>219</epage><pages>215-219</pages><issn>0340-6245</issn><eissn>2567-689X</eissn><abstract>Summary
Forty-one laboratories participated in an international collaborative study to assess the suitability of a panel of three genomic DNA samples as the 1st International Genetic Reference Panel for the Factor V Leiden (FVL) variant.The code numbers of the materials were 03/254 (FV wild type), 03/260 (FVL homozygote) and 03/248 (FVL heterozygote).The participants evaluated the panel against their in-house controls which were known patient samples and commercial controls. In total, 859 genotype tests were carried out on the panel, with an error rate of 0.7%.The errors were not related to specific samples of the panel or to any specific techniques.The findings of this study have indicated that this panel is suitable to be used as a reference material for genotyping of factor V Leiden. It was therefore recommended that the three genomic DNA samples be established as the 1st International Genetic Reference Panel for Factor V Leiden, Human gDNA, 04/224. This recommendation was approved by the Scientific and Standardization Committee (SSC) of the ISTH (International Society on Thrombosis and Haemostasis) in June 2004 and the Expert Committee on Biological Standardization (ECBS) of theWorld Health Organization (WHO) in November 2004.</abstract><pub>Schattauer GmbH</pub><doi>10.1160/TH05-11-0767</doi><tpages>5</tpages></addata></record> |
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| ispartof | Thrombosis and haemostasis, 2006, Vol.95 (2), p.215-219 |
| issn | 0340-6245 2567-689X |
| language | eng |
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| source | Thieme Connect Journals |
| subjects | New Technologies, Diagnostic Tools and Drugs |
| title | Establishment of the 1st International Genetic Reference Panel for Factor V Leiden, human gDNA |
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