A murine model of deep vein thrombosis Characterization and validation in transgenic mice

Summary Deep vein thrombosis (DVT) occurs with high prevalence in association with a number of risk factors, including major surgery, trauma, obesity, bed rest (>5 days), cancer, a previous history of DVT, and several predisposing prothrombotic mutations. A novel murine model of DVT was developed...

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Veröffentlicht in:	Thrombosis and haemostasis 2005-09, Vol.94 (3), p.498-503
Hauptverfasser:	Cooley, Brian C., Szema, Linda, Chen, Chao-Ying, Schwab, Jeffrey P., Schmeling, Gregory
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticoagulants - administration & dosage Anticoagulants - pharmacology Biological and medical sciences Blood Coagulation, Fibrinolysis and Cellular Haemostasis Blood coagulation. Blood cells Chlorides Coronary Artery Disease - etiology Coronary Artery Disease - pathology Coronary Artery Disease - physiopathology Coronary Vessels - pathology Disease Models, Animal Drug Evaluation, Preclinical - methods Electric Stimulation Factor V - genetics Femoral Vein - drug effects Femoral Vein - pathology Ferric Compounds Fundamental and applied biological sciences. Psychology Hematologic and hematopoietic diseases Heparin - administration & dosage Heparin - pharmacology Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Molecular and cellular biology Platelet diseases and coagulopathies Point Mutation Reproducibility of Results Venous Thrombosis - etiology Venous Thrombosis - pathology Venous Thrombosis - physiopathology
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