Effect of recombinant factor VIIa on melagatran-induced inhibition of thrombin generation and platelet activation in healthy volunteers

Summary The objectives were to investigate whether activation of the extrinsic coagulation cascade by recombinant factor VIIa (rFVIIa) reverses the inhibition of thrombin generation and platelet activation by melagatran, the active form of the oral direct thrombin inhibitor ximelagatran. In a single...

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Veröffentlicht in:	Thrombosis and haemostasis 2004-06, Vol.91 (6), p.1090-1096
Hauptverfasser:	Wolzt, Michael, Levi, Marcel, Sarich, Troy C., Boström, Stig L., Eriksson, Ulf G., Eriksson-Lepkowska, Maria, Svensson, Mia, Weitz, Jeffrey I., Elg, Margareta, Wåhlander, Karin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Azetidines Benzylamines Biological and medical sciences Biomarkers - blood Blood Coagulation Tests Blood Coagulation, Fibrinolysis and Cellular Haemostasis Blood coagulation. Blood cells Dose-Response Relationship, Drug Drug Interactions Factor VII - administration & dosage Factor VII - pharmacology Factor VIIa Fundamental and applied biological sciences. Psychology Glycine - administration & dosage Glycine - analogs & derivatives Glycine - pharmacology Hematologic and hematopoietic diseases Humans Male Medical sciences Molecular and cellular biology Platelet Activation - drug effects Platelet diseases and coagulopathies Recombinant Proteins - administration & dosage Recombinant Proteins - pharmacology Single-Blind Method Thrombosis - drug therapy Thrombosis - prevention & control Time Factors
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