Body Composition Predictors of Complicated Crohn’s Disease
Background: High visceral adipose tissue (VAT) and creeping fat (CrF) in Crohn’s disease (CD) have been widely recognized. The VAT to subcutaneous adipose tissue (SAT) ratio and sarcopenia have been associated with CD complications. Studies regarding the influence of body composition predictors on C...
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| Veröffentlicht in: | Digestive diseases (Basel) 2023-07, Vol.41 (4), p.589-599 |
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| creator | Barajas Ordonez, Felix Melekh, Bohdan Rodríguez-Feria, Pablo Melekh, Oksana Thormann, Maximilian Damm, Robert Omari, Jazan Pech, Maciej Surov, Alexey |
| description | Background: High visceral adipose tissue (VAT) and creeping fat (CrF) in Crohn’s disease (CD) have been widely recognized. The VAT to subcutaneous adipose tissue (SAT) ratio and sarcopenia have been associated with CD complications. Studies regarding the influence of body composition predictors on CD complications assessed with magnetic resonance enterography (MRE) are scarce. Aim: The aim of this study was to assess body composition parameters and CrF in opportunistic MRE as predictors of complicated CD. Methods: This was a retrospective study of 114 patients with inflammatory (n = 54) and complicated (n = 60) CD. The semiautomated assessment of body composition and the qualitative evaluation of CrF were performed. Results: Body composition parameters did not differ between both groups regarding the body mass index (p = 0.50), total adipose tissue index (TATI) (p = 0.14), subcutaneous adipose tissue index (SATI) (p = 0.17), visceral adipose tissue index (VATI) (p = 0.33), VAT/SAT ratio (p = 0.77), intramuscular adipose tissue (p = 0.64), skeletal muscle index (p = 0.22), and sarcopenia (p = 0.50). 47 strictures, 18 fistulae, and seven abscesses were identified. Fistulae were more likely to occur in patients with CrF (odds ratio [OR] 5.07, 95% confidence interval [CI] 1.76–14.56; p= |
| doi_str_mv | 10.1159/000529426 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1159_000529426</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2771636810</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-b2b6e7e583126e17679158b923c3faff06d4500b3776259d41a9f1a84cd74ac83</originalsourceid><addsrcrecordid>eNpt0E1LwzAYB_AgipvTg3eRghc9VPPSJC0Iop1vMNCDnkOaplu0a2rSCbv5Nfx6fhKrnUXBXHL4__Lk4Q_ALoLHCNHkBEJIcRJhtgaGKMIoTGJO18EQYspDzCkZgC3vnyBsMWebYEAYxxBDPgSnFzZfBqmd19abxtgquHc6N6qxzge2-E5Ko2Sj8yB1dlZ9vL37YGy8ll5vg41Cll7vrO4ReLy6fEhvwsnd9W16PglVhGkTZjhjmmsaE4SZRpzxBNE4SzBRpJBFAVkeUQgzwjnDNMkjJJMCyThSOY-kiskInHVz60U217nSVeNkKWpn5tIthZVG_E0qMxNT-yoQ5O1BuJ1wuJrg7MtC-0bMjVe6LGWl7cIL3CpGWIxgS486qpz13umi_wdB8VW36Otu7f7vxXr5028L9jrwLN1Uux707w_-jcfj206IOi_IJwfuj54</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2771636810</pqid></control><display><type>article</type><title>Body Composition Predictors of Complicated Crohn’s Disease</title><source>MEDLINE</source><source>Karger Journals</source><source>Alma/SFX Local Collection</source><creator>Barajas Ordonez, Felix ; Melekh, Bohdan ; Rodríguez-Feria, Pablo ; Melekh, Oksana ; Thormann, Maximilian ; Damm, Robert ; Omari, Jazan ; Pech, Maciej ; Surov, Alexey</creator><creatorcontrib>Barajas Ordonez, Felix ; Melekh, Bohdan ; Rodríguez-Feria, Pablo ; Melekh, Oksana ; Thormann, Maximilian ; Damm, Robert ; Omari, Jazan ; Pech, Maciej ; Surov, Alexey</creatorcontrib><description>Background: High visceral adipose tissue (VAT) and creeping fat (CrF) in Crohn’s disease (CD) have been widely recognized. The VAT to subcutaneous adipose tissue (SAT) ratio and sarcopenia have been associated with CD complications. Studies regarding the influence of body composition predictors on CD complications assessed with magnetic resonance enterography (MRE) are scarce. Aim: The aim of this study was to assess body composition parameters and CrF in opportunistic MRE as predictors of complicated CD. Methods: This was a retrospective study of 114 patients with inflammatory (n = 54) and complicated (n = 60) CD. The semiautomated assessment of body composition and the qualitative evaluation of CrF were performed. Results: Body composition parameters did not differ between both groups regarding the body mass index (p = 0.50), total adipose tissue index (TATI) (p = 0.14), subcutaneous adipose tissue index (SATI) (p = 0.17), visceral adipose tissue index (VATI) (p = 0.33), VAT/SAT ratio (p = 0.77), intramuscular adipose tissue (p = 0.64), skeletal muscle index (p = 0.22), and sarcopenia (p = 0.50). 47 strictures, 18 fistulae, and seven abscesses were identified. Fistulae were more likely to occur in patients with CrF (odds ratio [OR] 5.07, 95% confidence interval [CI] 1.76–14.56; p=<0.001) and high VAT/SAT ratio (OR: 3.82, 95% CI 1.34–10.85; p = 0.01). Conclusion: Body composition measurements in CD patients displayed no statistically significant difference between the groups of inflammatory and complicated disease. Nonetheless, CD patients stratified in the group of high VAT/SAT ratio and the presence of CrF should be recognized as risk groups for the occurrence of fistulae.</description><identifier>ISSN: 0257-2753</identifier><identifier>EISSN: 1421-9875</identifier><identifier>DOI: 10.1159/000529426</identifier><identifier>PMID: 36720207</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adipose Tissue - pathology ; Body Composition - physiology ; Body Mass Index ; Crohn Disease - complications ; Crohn Disease - pathology ; Humans ; Retrospective Studies ; Sarcopenia ; Small and Large Bowel ; Small and Large Bowel: Research Article</subject><ispartof>Digestive diseases (Basel), 2023-07, Vol.41 (4), p.589-599</ispartof><rights>The Author(s). Published by S. Karger AG, Basel</rights><rights>2023 S. Karger AG, Basel.</rights><rights>The Author(s). Published by S. Karger AG, Basel 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-b2b6e7e583126e17679158b923c3faff06d4500b3776259d41a9f1a84cd74ac83</citedby><orcidid>0000-0002-9273-3943 ; 0000-0002-7140-6775 ; 0000-0002-0362-3612 ; 0000-0002-7320-0084 ; 0000-0002-3817-1513</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36720207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barajas Ordonez, Felix</creatorcontrib><creatorcontrib>Melekh, Bohdan</creatorcontrib><creatorcontrib>Rodríguez-Feria, Pablo</creatorcontrib><creatorcontrib>Melekh, Oksana</creatorcontrib><creatorcontrib>Thormann, Maximilian</creatorcontrib><creatorcontrib>Damm, Robert</creatorcontrib><creatorcontrib>Omari, Jazan</creatorcontrib><creatorcontrib>Pech, Maciej</creatorcontrib><creatorcontrib>Surov, Alexey</creatorcontrib><title>Body Composition Predictors of Complicated Crohn’s Disease</title><title>Digestive diseases (Basel)</title><addtitle>Dig Dis</addtitle><description>Background: High visceral adipose tissue (VAT) and creeping fat (CrF) in Crohn’s disease (CD) have been widely recognized. The VAT to subcutaneous adipose tissue (SAT) ratio and sarcopenia have been associated with CD complications. Studies regarding the influence of body composition predictors on CD complications assessed with magnetic resonance enterography (MRE) are scarce. Aim: The aim of this study was to assess body composition parameters and CrF in opportunistic MRE as predictors of complicated CD. Methods: This was a retrospective study of 114 patients with inflammatory (n = 54) and complicated (n = 60) CD. The semiautomated assessment of body composition and the qualitative evaluation of CrF were performed. Results: Body composition parameters did not differ between both groups regarding the body mass index (p = 0.50), total adipose tissue index (TATI) (p = 0.14), subcutaneous adipose tissue index (SATI) (p = 0.17), visceral adipose tissue index (VATI) (p = 0.33), VAT/SAT ratio (p = 0.77), intramuscular adipose tissue (p = 0.64), skeletal muscle index (p = 0.22), and sarcopenia (p = 0.50). 47 strictures, 18 fistulae, and seven abscesses were identified. Fistulae were more likely to occur in patients with CrF (odds ratio [OR] 5.07, 95% confidence interval [CI] 1.76–14.56; p=<0.001) and high VAT/SAT ratio (OR: 3.82, 95% CI 1.34–10.85; p = 0.01). Conclusion: Body composition measurements in CD patients displayed no statistically significant difference between the groups of inflammatory and complicated disease. Nonetheless, CD patients stratified in the group of high VAT/SAT ratio and the presence of CrF should be recognized as risk groups for the occurrence of fistulae.</description><subject>Adipose Tissue - pathology</subject><subject>Body Composition - physiology</subject><subject>Body Mass Index</subject><subject>Crohn Disease - complications</subject><subject>Crohn Disease - pathology</subject><subject>Humans</subject><subject>Retrospective Studies</subject><subject>Sarcopenia</subject><subject>Small and Large Bowel</subject><subject>Small and Large Bowel: Research Article</subject><issn>0257-2753</issn><issn>1421-9875</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>EIF</sourceid><recordid>eNpt0E1LwzAYB_AgipvTg3eRghc9VPPSJC0Iop1vMNCDnkOaplu0a2rSCbv5Nfx6fhKrnUXBXHL4__Lk4Q_ALoLHCNHkBEJIcRJhtgaGKMIoTGJO18EQYspDzCkZgC3vnyBsMWebYEAYxxBDPgSnFzZfBqmd19abxtgquHc6N6qxzge2-E5Ko2Sj8yB1dlZ9vL37YGy8ll5vg41Cll7vrO4ReLy6fEhvwsnd9W16PglVhGkTZjhjmmsaE4SZRpzxBNE4SzBRpJBFAVkeUQgzwjnDNMkjJJMCyThSOY-kiskInHVz60U217nSVeNkKWpn5tIthZVG_E0qMxNT-yoQ5O1BuJ1wuJrg7MtC-0bMjVe6LGWl7cIL3CpGWIxgS486qpz13umi_wdB8VW36Otu7f7vxXr5028L9jrwLN1Uux707w_-jcfj206IOi_IJwfuj54</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Barajas Ordonez, Felix</creator><creator>Melekh, Bohdan</creator><creator>Rodríguez-Feria, Pablo</creator><creator>Melekh, Oksana</creator><creator>Thormann, Maximilian</creator><creator>Damm, Robert</creator><creator>Omari, Jazan</creator><creator>Pech, Maciej</creator><creator>Surov, Alexey</creator><general>S. Karger AG</general><scope>M--</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9273-3943</orcidid><orcidid>https://orcid.org/0000-0002-7140-6775</orcidid><orcidid>https://orcid.org/0000-0002-0362-3612</orcidid><orcidid>https://orcid.org/0000-0002-7320-0084</orcidid><orcidid>https://orcid.org/0000-0002-3817-1513</orcidid></search><sort><creationdate>20230701</creationdate><title>Body Composition Predictors of Complicated Crohn’s Disease</title><author>Barajas Ordonez, Felix ; Melekh, Bohdan ; Rodríguez-Feria, Pablo ; Melekh, Oksana ; Thormann, Maximilian ; Damm, Robert ; Omari, Jazan ; Pech, Maciej ; Surov, Alexey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-b2b6e7e583126e17679158b923c3faff06d4500b3776259d41a9f1a84cd74ac83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adipose Tissue - pathology</topic><topic>Body Composition - physiology</topic><topic>Body Mass Index</topic><topic>Crohn Disease - complications</topic><topic>Crohn Disease - pathology</topic><topic>Humans</topic><topic>Retrospective Studies</topic><topic>Sarcopenia</topic><topic>Small and Large Bowel</topic><topic>Small and Large Bowel: Research Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barajas Ordonez, Felix</creatorcontrib><creatorcontrib>Melekh, Bohdan</creatorcontrib><creatorcontrib>Rodríguez-Feria, Pablo</creatorcontrib><creatorcontrib>Melekh, Oksana</creatorcontrib><creatorcontrib>Thormann, Maximilian</creatorcontrib><creatorcontrib>Damm, Robert</creatorcontrib><creatorcontrib>Omari, Jazan</creatorcontrib><creatorcontrib>Pech, Maciej</creatorcontrib><creatorcontrib>Surov, Alexey</creatorcontrib><collection>Karger Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Digestive diseases (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barajas Ordonez, Felix</au><au>Melekh, Bohdan</au><au>Rodríguez-Feria, Pablo</au><au>Melekh, Oksana</au><au>Thormann, Maximilian</au><au>Damm, Robert</au><au>Omari, Jazan</au><au>Pech, Maciej</au><au>Surov, Alexey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body Composition Predictors of Complicated Crohn’s Disease</atitle><jtitle>Digestive diseases (Basel)</jtitle><addtitle>Dig Dis</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>41</volume><issue>4</issue><spage>589</spage><epage>599</epage><pages>589-599</pages><issn>0257-2753</issn><eissn>1421-9875</eissn><abstract>Background: High visceral adipose tissue (VAT) and creeping fat (CrF) in Crohn’s disease (CD) have been widely recognized. The VAT to subcutaneous adipose tissue (SAT) ratio and sarcopenia have been associated with CD complications. Studies regarding the influence of body composition predictors on CD complications assessed with magnetic resonance enterography (MRE) are scarce. Aim: The aim of this study was to assess body composition parameters and CrF in opportunistic MRE as predictors of complicated CD. Methods: This was a retrospective study of 114 patients with inflammatory (n = 54) and complicated (n = 60) CD. The semiautomated assessment of body composition and the qualitative evaluation of CrF were performed. Results: Body composition parameters did not differ between both groups regarding the body mass index (p = 0.50), total adipose tissue index (TATI) (p = 0.14), subcutaneous adipose tissue index (SATI) (p = 0.17), visceral adipose tissue index (VATI) (p = 0.33), VAT/SAT ratio (p = 0.77), intramuscular adipose tissue (p = 0.64), skeletal muscle index (p = 0.22), and sarcopenia (p = 0.50). 47 strictures, 18 fistulae, and seven abscesses were identified. Fistulae were more likely to occur in patients with CrF (odds ratio [OR] 5.07, 95% confidence interval [CI] 1.76–14.56; p=<0.001) and high VAT/SAT ratio (OR: 3.82, 95% CI 1.34–10.85; p = 0.01). Conclusion: Body composition measurements in CD patients displayed no statistically significant difference between the groups of inflammatory and complicated disease. Nonetheless, CD patients stratified in the group of high VAT/SAT ratio and the presence of CrF should be recognized as risk groups for the occurrence of fistulae.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>36720207</pmid><doi>10.1159/000529426</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9273-3943</orcidid><orcidid>https://orcid.org/0000-0002-7140-6775</orcidid><orcidid>https://orcid.org/0000-0002-0362-3612</orcidid><orcidid>https://orcid.org/0000-0002-7320-0084</orcidid><orcidid>https://orcid.org/0000-0002-3817-1513</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Digestive diseases (Basel), 2023-07, Vol.41 (4), p.589-599 |
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| subjects | Adipose Tissue - pathology Body Composition - physiology Body Mass Index Crohn Disease - complications Crohn Disease - pathology Humans Retrospective Studies Sarcopenia Small and Large Bowel Small and Large Bowel: Research Article |
| title | Body Composition Predictors of Complicated Crohn’s Disease |
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