BRAF and MEK Inhibitor Treatment for Metastatic Undifferentiated Sarcoma of the Spermatic Cord with BRAF V600E Mutation

Abstract An 18-year-old Japanese man was diagnosed with an undifferentiated sarcoma of the spermatic cord, with multiple distant metastases to the lungs and bones. The patient received doxorubicin-based standard chemotherapy. Although the chemotherapy was effective, it induced severe adverse events,...

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Veröffentlicht in:	Case Reports in Oncology 2022-08, Vol.15 (2), p.762-769
Hauptverfasser:	Saijo, Ken, Imai, Hiroo, Katayama, Hiromichi, Fujishima, Fumiyoshi, Nakamura, Kenichi, Kasahara, Yuki, Ouchi, Kota, Komine, Keigo, Shirota, Hidekazu, Takahashi, Masanobu, Ishioka, Chikashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anorexia braf v600e Cancer Cancer therapies Case Report Case reports Case studies Chemotherapy Clinical outcomes Clinical trials comprehensive genomic profiling dabrafenib Drug dosages Drug therapy Gene mutations Genetic aspects Inhibitor drugs Medical imaging Melanoma Metastasis Mutation Neutropenia Patients Sarcoma Scintigraphy Skin cancer Spinal cord Targeted cancer therapy Testicular cancer trametinib
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