Bowel Perforation in a Patient with Hepatocellular Carcinoma during Lenvatinib Treatment

Bowel Perforation in a Patient with Hepatocellular Carcinoma during Lenvatinib Treatment

We present a case of severe bowel perforation during lenvatinib treatment for advanced hepatocellular carcinoma. Although the Hartmann’s procedure was performed, the patient died 48 h after the operation. The histopathological findings suggested that lenvatinib was involved in the etiology of bowel...

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Veröffentlicht in:Case Reports in Gastroenterology 2022-08, Vol.16 (2), p.502-506
Hauptverfasser: Mizokami, Ken, Watanabe, Akiko, Yamaguchi, Eriko, Saito, Akira
Format: Artikel
Sprache:eng
Schlagworte:
Abdomen
bowel perforation
Case reports
Cellular signal transduction
Development and progression
Drug therapy
Growth factors
Health aspects
hepatocellular carcinoma
Hepatoma
Injuries
Intestines
Kinases
lenvatinib
Liver cancer
Mortality
Single Case
Stem cells
Tyrosine
Vascular endothelial growth factor
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Beschreibung
Zusammenfassung:We present a case of severe bowel perforation during lenvatinib treatment for advanced hepatocellular carcinoma. Although the Hartmann’s procedure was performed, the patient died 48 h after the operation. The histopathological findings suggested that lenvatinib was involved in the etiology of bowel perforation in this case.
ISSN:1662-0631
1662-0631
DOI:10.1159/000525569