Epidemiology of de novo Acute Myeloid Leukemia in Kuwait per the 2016 WHO Classification
Objective: Acute myeloid leukemia (AML) is a hematological malignancy that arises from the clonal proliferation of immature myeloid cells. Although the number of AML cases has dramatically increased worldwide, information on its prevalence and incidence in Kuwait is lacking. This study reports the i...
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| Veröffentlicht in: | Medical Principles and Practice 2022-07, Vol.31 (3), p.284-292 |
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| creator | Alshemmari, Salem H. Almazyad, Mazyad Ram, Mohan John, Liby Mariamma Alhuraiji, Ahmed |
| description | Objective: Acute myeloid leukemia (AML) is a hematological malignancy that arises from the clonal proliferation of immature myeloid cells. Although the number of AML cases has dramatically increased worldwide, information on its prevalence and incidence in Kuwait is lacking. This study reports the incidence of AML and patient demographics in the country from 2014 to 2020, based on the 2016 WHO classification of AML. Subjects and Methods: Data on patients with AML, including acute promyelocytic leukemia (APL), were collected from a clinical cohort with 281 cases analyzed in this study. Results: The overall median age of the population was 47 years with a 1.1:1 male-to-female ratio. Over the study period, the incidence of AML demonstrated a general increasing trend, with the highest and lowest overall incidence occurring in 2018 and 2015, respectively. The frequency of APL in our cohort was 8.9%. Regarding the 2017 European LeukemiaNet (ELN) risk stratification of patients with AML, 37%, 46%, and 17% of patients had a favorable, intermediate, and adverse risk, respectively. A total of 57% of cases achieved complete remission post-induction, and the median overall survival was 37 months. Conclusion: Our study may help predict the future trends of AML in Kuwait to help improve clinical management and patient outcomes. |
| doi_str_mv | 10.1159/000524641 |
| format | Article |
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Although the number of AML cases has dramatically increased worldwide, information on its prevalence and incidence in Kuwait is lacking. This study reports the incidence of AML and patient demographics in the country from 2014 to 2020, based on the 2016 WHO classification of AML. Subjects and Methods: Data on patients with AML, including acute promyelocytic leukemia (APL), were collected from a clinical cohort with 281 cases analyzed in this study. Results: The overall median age of the population was 47 years with a 1.1:1 male-to-female ratio. Over the study period, the incidence of AML demonstrated a general increasing trend, with the highest and lowest overall incidence occurring in 2018 and 2015, respectively. The frequency of APL in our cohort was 8.9%. Regarding the 2017 European LeukemiaNet (ELN) risk stratification of patients with AML, 37%, 46%, and 17% of patients had a favorable, intermediate, and adverse risk, respectively. A total of 57% of cases achieved complete remission post-induction, and the median overall survival was 37 months. Conclusion: Our study may help predict the future trends of AML in Kuwait to help improve clinical management and patient outcomes.</description><identifier>ISSN: 1011-7571</identifier><identifier>EISSN: 1423-0151</identifier><identifier>DOI: 10.1159/000524641</identifier><identifier>PMID: 35468599</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adults ; Age ; Analysis ; Cancer therapies ; Chemotherapy ; Classification ; Demographics ; Epidemiology ; Females ; Leukemia ; Males ; Medical prognosis ; Original Paper ; Patients ; Population ; Statistical analysis</subject><ispartof>Medical Principles and Practice, 2022-07, Vol.31 (3), p.284-292</ispartof><rights>2022 The Author(s). Published by S. Karger AG, Basel</rights><rights>The Author(s). Published by S. Karger AG, Basel.</rights><rights>COPYRIGHT 2022 S. Karger AG</rights><rights>2022 The Author(s). Published by S. Karger AG, Basel . This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-ecc803f93978834301f2b0318ec675d6d06571f8f296b67dad02cf8ce0d947bf3</citedby><cites>FETCH-LOGICAL-c519t-ecc803f93978834301f2b0318ec675d6d06571f8f296b67dad02cf8ce0d947bf3</cites><orcidid>0000-0002-5597-5839</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275004/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275004/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27634,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35468599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alshemmari, Salem H.</creatorcontrib><creatorcontrib>Almazyad, Mazyad</creatorcontrib><creatorcontrib>Ram, Mohan</creatorcontrib><creatorcontrib>John, Liby Mariamma</creatorcontrib><creatorcontrib>Alhuraiji, Ahmed</creatorcontrib><title>Epidemiology of de novo Acute Myeloid Leukemia in Kuwait per the 2016 WHO Classification</title><title>Medical Principles and Practice</title><addtitle>Med Princ Pract</addtitle><description>Objective: Acute myeloid leukemia (AML) is a hematological malignancy that arises from the clonal proliferation of immature myeloid cells. Although the number of AML cases has dramatically increased worldwide, information on its prevalence and incidence in Kuwait is lacking. This study reports the incidence of AML and patient demographics in the country from 2014 to 2020, based on the 2016 WHO classification of AML. Subjects and Methods: Data on patients with AML, including acute promyelocytic leukemia (APL), were collected from a clinical cohort with 281 cases analyzed in this study. Results: The overall median age of the population was 47 years with a 1.1:1 male-to-female ratio. Over the study period, the incidence of AML demonstrated a general increasing trend, with the highest and lowest overall incidence occurring in 2018 and 2015, respectively. The frequency of APL in our cohort was 8.9%. Regarding the 2017 European LeukemiaNet (ELN) risk stratification of patients with AML, 37%, 46%, and 17% of patients had a favorable, intermediate, and adverse risk, respectively. A total of 57% of cases achieved complete remission post-induction, and the median overall survival was 37 months. Conclusion: Our study may help predict the future trends of AML in Kuwait to help improve clinical management and patient outcomes.</description><subject>Adults</subject><subject>Age</subject><subject>Analysis</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Classification</subject><subject>Demographics</subject><subject>Epidemiology</subject><subject>Females</subject><subject>Leukemia</subject><subject>Males</subject><subject>Medical prognosis</subject><subject>Original Paper</subject><subject>Patients</subject><subject>Population</subject><subject>Statistical analysis</subject><issn>1011-7571</issn><issn>1423-0151</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkU1v1DAQhiMEoqVw4I6QJS5wSBnHsRNfkFarliK2ag8guFlee7x1m42DnRTtv69XuywfQj7YGj_zzjszRfGSwimlXL4HAF7VoqaPimNaV6wEyunj_AZKy4Y39Kh4ltJtxlrG4GlxxHgtWi7lcfH9bPAW1z50YbUhwRGLpA_3gczMNCK53GAXvCULnO4ypYnvyefpp_YjGTCS8QZJBVSQbxdXZN7plLzzRo8-9M-LJ053CV_s75Pi6_nZl_lFubj6-Gk-W5SGUzmWaEwLzEkmm7ZlNQPqqiUw2qIRDbfCgsj-XesqKZaisdpCZVxrEKysm6VjJ8WHne4wLddoDfZj1J0aol_ruFFBe_X3T-9v1CrcK1k1HKDOAm_3AjH8mDCNau2Twa7TPYYpqUpwzgUIKTL65h_0Nkyxz-2pSkJ2zSnfUqc7aqU7VL53Idc1-WznbEKPzuf4rKG1bIHTNie82yWYGFKK6A7uKajtgtVhwZl9_We7B_LXRn97vNNxhfEAXF5f7yTUYLdTe_Vfal_lAc9ksy0</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Alshemmari, Salem H.</creator><creator>Almazyad, Mazyad</creator><creator>Ram, Mohan</creator><creator>John, Liby Mariamma</creator><creator>Alhuraiji, Ahmed</creator><general>S. Karger AG</general><scope>M--</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5597-5839</orcidid></search><sort><creationdate>20220701</creationdate><title>Epidemiology of de novo Acute Myeloid Leukemia in Kuwait per the 2016 WHO Classification</title><author>Alshemmari, Salem H. ; Almazyad, Mazyad ; Ram, Mohan ; John, Liby Mariamma ; Alhuraiji, Ahmed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-ecc803f93978834301f2b0318ec675d6d06571f8f296b67dad02cf8ce0d947bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adults</topic><topic>Age</topic><topic>Analysis</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Classification</topic><topic>Demographics</topic><topic>Epidemiology</topic><topic>Females</topic><topic>Leukemia</topic><topic>Males</topic><topic>Medical prognosis</topic><topic>Original Paper</topic><topic>Patients</topic><topic>Population</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alshemmari, Salem H.</creatorcontrib><creatorcontrib>Almazyad, Mazyad</creatorcontrib><creatorcontrib>Ram, Mohan</creatorcontrib><creatorcontrib>John, Liby Mariamma</creatorcontrib><creatorcontrib>Alhuraiji, Ahmed</creatorcontrib><collection>Karger Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical Principles and Practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alshemmari, Salem H.</au><au>Almazyad, Mazyad</au><au>Ram, Mohan</au><au>John, Liby Mariamma</au><au>Alhuraiji, Ahmed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology of de novo Acute Myeloid Leukemia in Kuwait per the 2016 WHO Classification</atitle><jtitle>Medical Principles and Practice</jtitle><addtitle>Med Princ Pract</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>31</volume><issue>3</issue><spage>284</spage><epage>292</epage><pages>284-292</pages><issn>1011-7571</issn><eissn>1423-0151</eissn><abstract>Objective: Acute myeloid leukemia (AML) is a hematological malignancy that arises from the clonal proliferation of immature myeloid cells. Although the number of AML cases has dramatically increased worldwide, information on its prevalence and incidence in Kuwait is lacking. This study reports the incidence of AML and patient demographics in the country from 2014 to 2020, based on the 2016 WHO classification of AML. Subjects and Methods: Data on patients with AML, including acute promyelocytic leukemia (APL), were collected from a clinical cohort with 281 cases analyzed in this study. Results: The overall median age of the population was 47 years with a 1.1:1 male-to-female ratio. Over the study period, the incidence of AML demonstrated a general increasing trend, with the highest and lowest overall incidence occurring in 2018 and 2015, respectively. The frequency of APL in our cohort was 8.9%. Regarding the 2017 European LeukemiaNet (ELN) risk stratification of patients with AML, 37%, 46%, and 17% of patients had a favorable, intermediate, and adverse risk, respectively. 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| subjects | Adults Age Analysis Cancer therapies Chemotherapy Classification Demographics Epidemiology Females Leukemia Males Medical prognosis Original Paper Patients Population Statistical analysis |
| title | Epidemiology of de novo Acute Myeloid Leukemia in Kuwait per the 2016 WHO Classification |
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