Increase in Chondroitin Sulfate and Decline in Arylsulfatase B May Contribute to Pathophysiology of COVID-19 Respiratory Failure

Introduction: The potential role of accumulation of chondroitin sulfates (CSs) in the pathobiology of COVID-19 has not been examined. Accumulation may occur by increased synthesis or by decline in activity of the enzyme arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) which requires oxygen...

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Veröffentlicht in:	Pathobiology (Basel) 2022-03, Vol.89 (2), p.81-91
Hauptverfasser:	Tzankov, Alexandar, Bhattacharyya, Sumit, Kotlo, Kumar, Tobacman, Joanne K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chondroitin Sulfates - metabolism COVID-19 Glycosaminoglycans - metabolism Humans Membrane Glycoproteins N-Acetylgalactosamine-4-Sulfatase - genetics N-Acetylgalactosamine-4-Sulfatase - metabolism Research Article Respiratory Insufficiency Sulfotransferases
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