Direct Blood Pressure-Independent Anti-Fibrotic Effects by the Selective Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone in Progressive Models of Kidney Fibrosis

Introduction: The nonsteroidal mineralocorticoid receptor (MR) antagonist finerenone and sodium-glucose cotransporter-2 (SGLT2) inhibitors have demonstrated clinical benefits in chronic kidney disease patients with type 2 diabetes. Precise molecular mechanisms responsible for these benefits are inco...

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Veröffentlicht in:	American journal of nephrology 2021-09, Vol.52 (7), p.588-601
Hauptverfasser:	Droebner, Karoline, Pavkovic, Mira, Grundmann, Manuel, Hartmann, Elke, Goea, Laura, Nordlohne, Johannes, Klar, Jürgen, Eitner, Frank, Kolkhof, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Adaptor Proteins, Signal Transducing - genetics Albuminuria - drug therapy Animal experimentation Animals Benzhydryl Compounds - therapeutic use Blood Pressure - drug effects Calcium-Binding Proteins - genetics Care and treatment Causes of Chronic kidney failure Collagen - genetics Collagen - metabolism Complications and side effects Creatinine - blood Development and progression Disease Models, Animal Dosage and administration Fibrosis Gene Expression - drug effects Glucosides - therapeutic use Kidney - pathology Kidney Diseases - drug therapy Kidney Diseases - etiology Kidney Diseases - metabolism Kidney Diseases - pathology Lymphocytes - pathology Male Methods Mice Mice, Inbred C57BL Mineralocorticoid Receptor Antagonists - pharmacology Mineralocorticoid Receptor Antagonists - therapeutic use Mineralocorticoids Monocytes - pathology Myofibroblasts - pathology Naphthyridines - pharmacology Naphthyridines - therapeutic use Novel Research Findings Pulmonary fibrosis Reperfusion Injury - complications RNA, Messenger - metabolism Serpin E2 - genetics Sodium-Glucose Transporter 2 Inhibitors - therapeutic use Ureteral Obstruction - complications
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