The Role of CXCL12 in Kidney Diseases: A Friend or Foe?
Background: Chemokines are a family of proteins mainly mediating the homing and migration of various cells. The CXC chemokine CXCL12 is a member of low-weight-molecular chemokines. In the kidney, CXCL12 is pivotal for renal development and exerts a modulatory effect in kidney diseases under differen...
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| Veröffentlicht in: | Kidney diseases 2021-05, Vol.7 (3), p.176-185 |
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| creator | Song, Anni Jiang, Anni Xiong, Wei Zhang, Chun |
| description | Background: Chemokines are a family of proteins mainly mediating the homing and migration of various cells. The CXC chemokine CXCL12 is a member of low-weight-molecular chemokines. In the kidney, CXCL12 is pivotal for renal development and exerts a modulatory effect in kidney diseases under different etiologic settings by binding with CXC chemokine receptor 4 (CXCR4) or CXC chemokine receptor 7 (CXCR7). Besides, CXCL12 also exerts homeostasis influence in diverse physical conditions and various pathological situations. Thus, we conclude the complicated relationship between CXCL12 and kidney diseases in this review. Summary: In renal development, CXCL12 contributes a lot to nephrogenesis and the formation of renal vasculature via correlating with CXCR4. CXCL12 also plays an essential role in renal recovery from acute kidney injury. However, the CXCL12/CXCR4 axis plays a dual regulatory role in the initiation and development of diabetic kidney disease as well as chronic allogeneic nephropathy after kidney transplantation through dialectical consideration. Additionally, the CXCL12/CXCR4 link is considered as a new risk factor for lupus nephritis and renal cell carcinoma. Key Messages: Plenty of studies have presented the influence of CXCL12 and the relation with corresponding receptors in diverse biological and pathological statuses. Simultaneously, some drugs and antagonists targeting CXCL12/CXCR4 axis effectively treat various kidney diseases. However, more researches are needed to explore thorough influence and mechanisms, providing more cues for clinical treatments. |
| doi_str_mv | 10.1159/000514913 |
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The CXC chemokine CXCL12 is a member of low-weight-molecular chemokines. In the kidney, CXCL12 is pivotal for renal development and exerts a modulatory effect in kidney diseases under different etiologic settings by binding with CXC chemokine receptor 4 (CXCR4) or CXC chemokine receptor 7 (CXCR7). Besides, CXCL12 also exerts homeostasis influence in diverse physical conditions and various pathological situations. Thus, we conclude the complicated relationship between CXCL12 and kidney diseases in this review. Summary: In renal development, CXCL12 contributes a lot to nephrogenesis and the formation of renal vasculature via correlating with CXCR4. CXCL12 also plays an essential role in renal recovery from acute kidney injury. However, the CXCL12/CXCR4 axis plays a dual regulatory role in the initiation and development of diabetic kidney disease as well as chronic allogeneic nephropathy after kidney transplantation through dialectical consideration. Additionally, the CXCL12/CXCR4 link is considered as a new risk factor for lupus nephritis and renal cell carcinoma. Key Messages: Plenty of studies have presented the influence of CXCL12 and the relation with corresponding receptors in diverse biological and pathological statuses. Simultaneously, some drugs and antagonists targeting CXCL12/CXCR4 axis effectively treat various kidney diseases. However, more researches are needed to explore thorough influence and mechanisms, providing more cues for clinical treatments.</description><identifier>ISSN: 2296-9381</identifier><identifier>EISSN: 2296-9357</identifier><identifier>DOI: 10.1159/000514913</identifier><identifier>PMID: 34179113</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>acute kidney injury ; cxcl12 ; cxcr4 ; Development and progression ; diabetic kidney disease ; Kidney diseases ; lupus nephritis ; Medical research ; Medicine, Experimental ; Proteins ; Review ; Review Article ; Saxagliptin ; Transplantation of organs, tissues, etc</subject><ispartof>Kidney diseases, 2021-05, Vol.7 (3), p.176-185</ispartof><rights>2021 The Author(s) Published by S. Karger AG, Basel</rights><rights>Copyright © 2021 by S. Karger AG, Basel.</rights><rights>COPYRIGHT 2021 S. Karger AG</rights><rights>Copyright © 2021 by S. Karger AG, Basel 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c623t-1f8905d1b8202221524354211f4bb3f6b2d2febb3bbdeeabe682495168ced2883</citedby><cites>FETCH-LOGICAL-c623t-1f8905d1b8202221524354211f4bb3f6b2d2febb3bbdeeabe682495168ced2883</cites><orcidid>0000-0003-3565-8024</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216017/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216017/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27614,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34179113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Anni</creatorcontrib><creatorcontrib>Jiang, Anni</creatorcontrib><creatorcontrib>Xiong, Wei</creatorcontrib><creatorcontrib>Zhang, Chun</creatorcontrib><title>The Role of CXCL12 in Kidney Diseases: A Friend or Foe?</title><title>Kidney diseases</title><addtitle>Kidney Dis</addtitle><description>Background: Chemokines are a family of proteins mainly mediating the homing and migration of various cells. The CXC chemokine CXCL12 is a member of low-weight-molecular chemokines. In the kidney, CXCL12 is pivotal for renal development and exerts a modulatory effect in kidney diseases under different etiologic settings by binding with CXC chemokine receptor 4 (CXCR4) or CXC chemokine receptor 7 (CXCR7). Besides, CXCL12 also exerts homeostasis influence in diverse physical conditions and various pathological situations. Thus, we conclude the complicated relationship between CXCL12 and kidney diseases in this review. Summary: In renal development, CXCL12 contributes a lot to nephrogenesis and the formation of renal vasculature via correlating with CXCR4. CXCL12 also plays an essential role in renal recovery from acute kidney injury. However, the CXCL12/CXCR4 axis plays a dual regulatory role in the initiation and development of diabetic kidney disease as well as chronic allogeneic nephropathy after kidney transplantation through dialectical consideration. Additionally, the CXCL12/CXCR4 link is considered as a new risk factor for lupus nephritis and renal cell carcinoma. Key Messages: Plenty of studies have presented the influence of CXCL12 and the relation with corresponding receptors in diverse biological and pathological statuses. Simultaneously, some drugs and antagonists targeting CXCL12/CXCR4 axis effectively treat various kidney diseases. However, more researches are needed to explore thorough influence and mechanisms, providing more cues for clinical treatments.</description><subject>acute kidney injury</subject><subject>cxcl12</subject><subject>cxcr4</subject><subject>Development and progression</subject><subject>diabetic kidney disease</subject><subject>Kidney diseases</subject><subject>lupus nephritis</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Proteins</subject><subject>Review</subject><subject>Review Article</subject><subject>Saxagliptin</subject><subject>Transplantation of organs, tissues, etc</subject><issn>2296-9381</issn><issn>2296-9357</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>DOA</sourceid><recordid>eNptkt9v0zAQgCMEYtPYA-8IReIFHjp85x-JeQBV7QrTKiGhIfFmOcml80jjYrdI--_nkhKoNPnBp_N3n8_yZdlLYBcAUr9njEkQGviT7BRRq4nmsng6xiWcZOcx3iUMJLAC1PPshAsoNAA_zYqbW8q_-Y5y3-azH7MlYO76_No1Pd3ncxfJRoof8mm-CI76JvchX3j69CJ71tou0vlhP8u-Ly5vZl8my6-fr2bT5aRWyLcTaEvNZANViQwRQaLgUiBAK6qKt6rCBltKYVU1RLYiVaLQElRZU4Nlyc-yq8HbeHtnNsGtbbg33jrzJ-HDytiwdXVHRmlBStUAAlFYkBY51ylTVlywglFyfRxcm121pqamfhtsdyQ9PundrVn536ZEUAyKJHh7EAT_a0dxa9Yu1tR1tie_iwalkLrUCvfomwFd2dSa61ufjPUeN9MClVZSKZ6oi0eotBpau9r31LqUPyp4NxTUwccYqB27B2b242DGcUjs6_-fO5J_P_9fjz9tWFEYgev5fFCYTdMm6tWj1OGWB2-IvfU</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Song, Anni</creator><creator>Jiang, Anni</creator><creator>Xiong, Wei</creator><creator>Zhang, Chun</creator><general>S. Karger AG</general><general>Karger Publishers</general><scope>M--</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-3565-8024</orcidid></search><sort><creationdate>20210501</creationdate><title>The Role of CXCL12 in Kidney Diseases: A Friend or Foe?</title><author>Song, Anni ; Jiang, Anni ; Xiong, Wei ; Zhang, Chun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c623t-1f8905d1b8202221524354211f4bb3f6b2d2febb3bbdeeabe682495168ced2883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>acute kidney injury</topic><topic>cxcl12</topic><topic>cxcr4</topic><topic>Development and progression</topic><topic>diabetic kidney disease</topic><topic>Kidney diseases</topic><topic>lupus nephritis</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Proteins</topic><topic>Review</topic><topic>Review Article</topic><topic>Saxagliptin</topic><topic>Transplantation of organs, tissues, etc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Anni</creatorcontrib><creatorcontrib>Jiang, Anni</creatorcontrib><creatorcontrib>Xiong, Wei</creatorcontrib><creatorcontrib>Zhang, Chun</creatorcontrib><collection>Karger Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Kidney diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Anni</au><au>Jiang, Anni</au><au>Xiong, Wei</au><au>Zhang, Chun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of CXCL12 in Kidney Diseases: A Friend or Foe?</atitle><jtitle>Kidney diseases</jtitle><addtitle>Kidney Dis</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>7</volume><issue>3</issue><spage>176</spage><epage>185</epage><pages>176-185</pages><issn>2296-9381</issn><eissn>2296-9357</eissn><abstract>Background: Chemokines are a family of proteins mainly mediating the homing and migration of various cells. The CXC chemokine CXCL12 is a member of low-weight-molecular chemokines. In the kidney, CXCL12 is pivotal for renal development and exerts a modulatory effect in kidney diseases under different etiologic settings by binding with CXC chemokine receptor 4 (CXCR4) or CXC chemokine receptor 7 (CXCR7). Besides, CXCL12 also exerts homeostasis influence in diverse physical conditions and various pathological situations. Thus, we conclude the complicated relationship between CXCL12 and kidney diseases in this review. Summary: In renal development, CXCL12 contributes a lot to nephrogenesis and the formation of renal vasculature via correlating with CXCR4. CXCL12 also plays an essential role in renal recovery from acute kidney injury. However, the CXCL12/CXCR4 axis plays a dual regulatory role in the initiation and development of diabetic kidney disease as well as chronic allogeneic nephropathy after kidney transplantation through dialectical consideration. Additionally, the CXCL12/CXCR4 link is considered as a new risk factor for lupus nephritis and renal cell carcinoma. Key Messages: Plenty of studies have presented the influence of CXCL12 and the relation with corresponding receptors in diverse biological and pathological statuses. Simultaneously, some drugs and antagonists targeting CXCL12/CXCR4 axis effectively treat various kidney diseases. However, more researches are needed to explore thorough influence and mechanisms, providing more cues for clinical treatments.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>34179113</pmid><doi>10.1159/000514913</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-3565-8024</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | acute kidney injury cxcl12 cxcr4 Development and progression diabetic kidney disease Kidney diseases lupus nephritis Medical research Medicine, Experimental Proteins Review Review Article Saxagliptin Transplantation of organs, tissues, etc |
| title | The Role of CXCL12 in Kidney Diseases: A Friend or Foe? |
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