COVID-19 and Extracellular Vesicles: An Intriguing Interplay
Background: The outbreak of severe acute respiratory syndrome β-coronavirus 2 (SARS-CoV-2) has the potential to become a long-lasting global health crisis. The number of people infected with the novel coronavirus has surpassed 22 million globally, resulting in over 700,000 deaths with more than 15 m...
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| Veröffentlicht in: | Kidney & blood pressure research 2020-10, Vol.45 (5), p.661-670 |
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| creator | Pocsfalvi, Gabriella Mammadova, Ramila Ramos Juarez, Ana Paulina Bokka, Ramesh Trepiccione, Francesco Capasso, Giovambattista |
| description | Background: The outbreak of severe acute respiratory syndrome β-coronavirus 2 (SARS-CoV-2) has the potential to become a long-lasting global health crisis. The number of people infected with the novel coronavirus has surpassed 22 million globally, resulting in over 700,000 deaths with more than 15 million people having recovered (https://covid19.who.int). Enormous efforts are underway for rapid vaccine and treatment developments. Amongst the many ways of tackling the novel coronavirus disease 2019 (COVID-19) pandemic, extracellular vesicles (EVs) are emerging. Summary: EVs are lipid bilayer-enclosed structures secreted from all types of cells, including those lining the respiratory tract. They have established roles in lung immunity and are involved in the pathogenesis of various lung diseases, including viral infection. In this review, we point out the roles and possible contribution of EVs in viral infections, as well as ongoing EV-based approaches for the treatment of COVID-19, including clinical trials. Key Messages: EVs share structural similarities to viruses and recent findings demonstrate that viruses exploit EVs for cellular exit and EVs exploit viral entry mechanisms for cargo delivery. Moreover, EV-virus interplay could be exploited for future antiviral drug and vaccine development. EV-based therapies, especially the mesenchymal stem cell-derived EVs, are being intensively studied for the treatment of COVID-19. |
| doi_str_mv | 10.1159/000511402 |
| format | Article |
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The number of people infected with the novel coronavirus has surpassed 22 million globally, resulting in over 700,000 deaths with more than 15 million people having recovered (https://covid19.who.int). Enormous efforts are underway for rapid vaccine and treatment developments. Amongst the many ways of tackling the novel coronavirus disease 2019 (COVID-19) pandemic, extracellular vesicles (EVs) are emerging. Summary: EVs are lipid bilayer-enclosed structures secreted from all types of cells, including those lining the respiratory tract. They have established roles in lung immunity and are involved in the pathogenesis of various lung diseases, including viral infection. In this review, we point out the roles and possible contribution of EVs in viral infections, as well as ongoing EV-based approaches for the treatment of COVID-19, including clinical trials. Key Messages: EVs share structural similarities to viruses and recent findings demonstrate that viruses exploit EVs for cellular exit and EVs exploit viral entry mechanisms for cargo delivery. Moreover, EV-virus interplay could be exploited for future antiviral drug and vaccine development. EV-based therapies, especially the mesenchymal stem cell-derived EVs, are being intensively studied for the treatment of COVID-19.</description><identifier>ISSN: 1420-4096</identifier><identifier>EISSN: 1423-0143</identifier><identifier>DOI: 10.1159/000511402</identifier><identifier>PMID: 32957112</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Antiviral Agents - administration & dosage ; Betacoronavirus ; Clinical trials ; Coronaviridae ; Coronavirus Infections - complications ; Coronavirus Infections - metabolism ; Coronavirus Infections - therapy ; Coronaviruses ; COVID-19 ; Development and progression ; Drug delivery systems ; Extracellular vesicles ; Extracellular Vesicles - metabolism ; Extracellular Vesicles - virology ; Genetic Therapy - trends ; Global health ; Health aspects ; Health services ; Humans ; Infections ; Lipid bilayers ; Lipids ; Lung diseases ; Lung Diseases - metabolism ; Lung Diseases - therapy ; Lung Diseases - virology ; Mesenchyme ; Organelles ; Pandemics ; Pathogenesis ; Physiological aspects ; Pneumonia, Viral - complications ; Pneumonia, Viral - metabolism ; Pneumonia, Viral - therapy ; Public health ; pulmonary disease ; Respiratory diseases ; Respiratory tract ; Review ; Review Article ; SARS-CoV-2 ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Stem cells ; Vaccine development ; Vaccines ; Vesicles ; Viral diseases ; Viral infections ; Virus Shedding - drug effects ; Virus Shedding - physiology ; Viruses</subject><ispartof>Kidney & blood pressure research, 2020-10, Vol.45 (5), p.661-670</ispartof><rights>2020 The Author(s) Published by S. Karger AG, Basel</rights><rights>2020 The Author(s) Published by S. Karger AG, Basel.</rights><rights>COPYRIGHT 2020 S. Karger AG</rights><rights>Copyright © 2020 by S. Karger AG, Basel 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c613t-b7f3eb90d4a37c3d131bcd8dbff81635196cb2088aa3e55c485bb630eac09f4f3</citedby><cites>FETCH-LOGICAL-c613t-b7f3eb90d4a37c3d131bcd8dbff81635196cb2088aa3e55c485bb630eac09f4f3</cites><orcidid>0000-0003-3469-8614</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,864,885,2102,27635,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32957112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pocsfalvi, Gabriella</creatorcontrib><creatorcontrib>Mammadova, Ramila</creatorcontrib><creatorcontrib>Ramos Juarez, Ana Paulina</creatorcontrib><creatorcontrib>Bokka, Ramesh</creatorcontrib><creatorcontrib>Trepiccione, Francesco</creatorcontrib><creatorcontrib>Capasso, Giovambattista</creatorcontrib><title>COVID-19 and Extracellular Vesicles: An Intriguing Interplay</title><title>Kidney & blood pressure research</title><addtitle>Kidney Blood Press Res</addtitle><description>Background: The outbreak of severe acute respiratory syndrome β-coronavirus 2 (SARS-CoV-2) has the potential to become a long-lasting global health crisis. The number of people infected with the novel coronavirus has surpassed 22 million globally, resulting in over 700,000 deaths with more than 15 million people having recovered (https://covid19.who.int). Enormous efforts are underway for rapid vaccine and treatment developments. Amongst the many ways of tackling the novel coronavirus disease 2019 (COVID-19) pandemic, extracellular vesicles (EVs) are emerging. Summary: EVs are lipid bilayer-enclosed structures secreted from all types of cells, including those lining the respiratory tract. They have established roles in lung immunity and are involved in the pathogenesis of various lung diseases, including viral infection. In this review, we point out the roles and possible contribution of EVs in viral infections, as well as ongoing EV-based approaches for the treatment of COVID-19, including clinical trials. Key Messages: EVs share structural similarities to viruses and recent findings demonstrate that viruses exploit EVs for cellular exit and EVs exploit viral entry mechanisms for cargo delivery. Moreover, EV-virus interplay could be exploited for future antiviral drug and vaccine development. EV-based therapies, especially the mesenchymal stem cell-derived EVs, are being intensively studied for the treatment of COVID-19.</description><subject>Antiviral Agents - administration & dosage</subject><subject>Betacoronavirus</subject><subject>Clinical trials</subject><subject>Coronaviridae</subject><subject>Coronavirus Infections - complications</subject><subject>Coronavirus Infections - metabolism</subject><subject>Coronavirus Infections - therapy</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Development and progression</subject><subject>Drug delivery systems</subject><subject>Extracellular vesicles</subject><subject>Extracellular Vesicles - metabolism</subject><subject>Extracellular Vesicles - virology</subject><subject>Genetic Therapy - trends</subject><subject>Global health</subject><subject>Health aspects</subject><subject>Health services</subject><subject>Humans</subject><subject>Infections</subject><subject>Lipid bilayers</subject><subject>Lipids</subject><subject>Lung diseases</subject><subject>Lung Diseases - metabolism</subject><subject>Lung Diseases - therapy</subject><subject>Lung Diseases - virology</subject><subject>Mesenchyme</subject><subject>Organelles</subject><subject>Pandemics</subject><subject>Pathogenesis</subject><subject>Physiological aspects</subject><subject>Pneumonia, Viral - complications</subject><subject>Pneumonia, Viral - metabolism</subject><subject>Pneumonia, Viral - therapy</subject><subject>Public health</subject><subject>pulmonary disease</subject><subject>Respiratory diseases</subject><subject>Respiratory tract</subject><subject>Review</subject><subject>Review Article</subject><subject>SARS-CoV-2</subject><subject>Severe acute respiratory syndrome</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Stem cells</subject><subject>Vaccine development</subject><subject>Vaccines</subject><subject>Vesicles</subject><subject>Viral diseases</subject><subject>Viral infections</subject><subject>Virus Shedding - drug effects</subject><subject>Virus Shedding - physiology</subject><subject>Viruses</subject><issn>1420-4096</issn><issn>1423-0143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DOA</sourceid><recordid>eNptks9rFDEUx4Motq4evIsM9KKHqckkmSRFhHWtulgoiPYa8nPMOjtZMzNi_3sznTpYkRwS3vu8b94vAJ4ieIoQFa8ghBQhAqt74BiRCpcQEXz_5g1LAkV9BB71_W7CIKwegiNcCcoQqo7B683l1fZdiUShOluc_xqSMq5tx1al4sr1wbSuPyvWXbHthhSaMXTN9HTp0Krrx-CBV23vntzeK_D1_fmXzcfy4vLDdrO-KE2N8FBq5rHTAlqiMDPYIoy0sdxq7zmqMUWiNrqCnCuFHaWGcKp1jaFTBgpPPF6B7axro9rJQwp7la5lVEHeGGJqpErDlKsUBjomkMFGEEKY06TmWEGrmeWqpjBrvZm1DqPeO2tcrku1d0TverrwTTbxp2SUYS6qLPDiViDFH6PrB7kP_dQz1bk49rLK__IM59JX4OQfdBfH1OVWZYoSyDCrWaZOZ6pRuYDQ-TgNIR_r9sHEzvmQ7esac4JJnl8OeDkHmBT7Pjm_ZI-gnBZCLguR2ed_l7uQfzYgA89m4LtKjUsLsMSf_Nf96e3nmZAH6_FvHqrCaQ</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Pocsfalvi, Gabriella</creator><creator>Mammadova, Ramila</creator><creator>Ramos Juarez, Ana Paulina</creator><creator>Bokka, Ramesh</creator><creator>Trepiccione, Francesco</creator><creator>Capasso, Giovambattista</creator><general>S. 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Key Messages: EVs share structural similarities to viruses and recent findings demonstrate that viruses exploit EVs for cellular exit and EVs exploit viral entry mechanisms for cargo delivery. Moreover, EV-virus interplay could be exploited for future antiviral drug and vaccine development. EV-based therapies, especially the mesenchymal stem cell-derived EVs, are being intensively studied for the treatment of COVID-19.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>32957112</pmid><doi>10.1159/000511402</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-3469-8614</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Kidney & blood pressure research, 2020-10, Vol.45 (5), p.661-670 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Karger Open Access |
| subjects | Antiviral Agents - administration & dosage Betacoronavirus Clinical trials Coronaviridae Coronavirus Infections - complications Coronavirus Infections - metabolism Coronavirus Infections - therapy Coronaviruses COVID-19 Development and progression Drug delivery systems Extracellular vesicles Extracellular Vesicles - metabolism Extracellular Vesicles - virology Genetic Therapy - trends Global health Health aspects Health services Humans Infections Lipid bilayers Lipids Lung diseases Lung Diseases - metabolism Lung Diseases - therapy Lung Diseases - virology Mesenchyme Organelles Pandemics Pathogenesis Physiological aspects Pneumonia, Viral - complications Pneumonia, Viral - metabolism Pneumonia, Viral - therapy Public health pulmonary disease Respiratory diseases Respiratory tract Review Review Article SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Stem cells Vaccine development Vaccines Vesicles Viral diseases Viral infections Virus Shedding - drug effects Virus Shedding - physiology Viruses |
| title | COVID-19 and Extracellular Vesicles: An Intriguing Interplay |
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