Vitamin E in Atopic Dermatitis: From Preclinical to Clinical Studies
Background: Oxidative stress and inflammation are some of the proposed mechanisms involved in the pathogenesis of atopic dermatitis (AD). Current pharmacotherapeutic approaches are effective yet they are not without adverse effects. Vitamin E has great potential as an adjunctive treatment for AD owi...
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| Veröffentlicht in: | Dermatology (Basel) 2021, Vol.237 (4), p.553-564 |
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| container_title | Dermatology (Basel) |
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| creator | Teo, Cheryl Wei Ling Tay, Shawn Han Yueh Tey, Hong Liang Ung, Yee Wei Yap, Wei Ney |
| description | Background: Oxidative stress and inflammation are some of the proposed mechanisms involved in the pathogenesis of atopic dermatitis (AD). Current pharmacotherapeutic approaches are effective yet they are not without adverse effects. Vitamin E has great potential as an adjunctive treatment for AD owing to its antioxidant and anti-inflammatory bioactivities. Summary: This review article summarizes the current available evidence from cellular, animal and clinical studies on the relationship between vitamin E and AD. The future prospects of vitamin E are also discussed. Vitamin E in practice does not show any toxicity to humans within a range of reasonable dosage. Albeit rarely, vitamin E as a contact allergen should be considered. Collectively, this review envisaged vitamin E as an adjunctive treatment for AD patients. Future research on the distinct effects of different vitamin E isoforms as well as their delivery system in skin disorders is needed. |
| doi_str_mv | 10.1159/000510653 |
| format | Article |
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Current pharmacotherapeutic approaches are effective yet they are not without adverse effects. Vitamin E has great potential as an adjunctive treatment for AD owing to its antioxidant and anti-inflammatory bioactivities. Summary: This review article summarizes the current available evidence from cellular, animal and clinical studies on the relationship between vitamin E and AD. The future prospects of vitamin E are also discussed. Vitamin E in practice does not show any toxicity to humans within a range of reasonable dosage. Albeit rarely, vitamin E as a contact allergen should be considered. Collectively, this review envisaged vitamin E as an adjunctive treatment for AD patients. Future research on the distinct effects of different vitamin E isoforms as well as their delivery system in skin disorders is needed.</description><identifier>ISSN: 1018-8665</identifier><identifier>EISSN: 1421-9832</identifier><identifier>DOI: 10.1159/000510653</identifier><identifier>PMID: 33070130</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Animals ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Atopic Dermatitis – Review Article ; Dermatitis, Atopic - blood ; Dermatitis, Atopic - drug therapy ; Humans ; Oxidative Stress - drug effects ; Skin Physiological Phenomena - drug effects ; Vitamin E - blood ; Vitamin E - pharmacology ; Vitamin E - therapeutic use</subject><ispartof>Dermatology (Basel), 2021, Vol.237 (4), p.553-564</ispartof><rights>2020 S. Karger AG, Basel</rights><rights>2020 S. 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Current pharmacotherapeutic approaches are effective yet they are not without adverse effects. Vitamin E has great potential as an adjunctive treatment for AD owing to its antioxidant and anti-inflammatory bioactivities. Summary: This review article summarizes the current available evidence from cellular, animal and clinical studies on the relationship between vitamin E and AD. The future prospects of vitamin E are also discussed. Vitamin E in practice does not show any toxicity to humans within a range of reasonable dosage. Albeit rarely, vitamin E as a contact allergen should be considered. Collectively, this review envisaged vitamin E as an adjunctive treatment for AD patients. Future research on the distinct effects of different vitamin E isoforms as well as their delivery system in skin disorders is needed.</description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Atopic Dermatitis – Review Article</subject><subject>Dermatitis, Atopic - blood</subject><subject>Dermatitis, Atopic - drug therapy</subject><subject>Humans</subject><subject>Oxidative Stress - drug effects</subject><subject>Skin Physiological Phenomena - drug effects</subject><subject>Vitamin E - blood</subject><subject>Vitamin E - pharmacology</subject><subject>Vitamin E - therapeutic use</subject><issn>1018-8665</issn><issn>1421-9832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0DtPwzAQB3ALgSgUBnaEIrHAEPD5FZut6gOQikC81siJHWRImmAnA9-eoLSdWO5Out_d8EfoBPAVAFfXGGMOWHC6gw6AEYiVpGS3nzHIWArBR-gwhM-eEZmofTSiFCcYKD5As3fX6sqtonnUl0lbNy6PZtZXunWtCzfRwtdV9ORtXrqVy3UZtXU03cwvbWecDUdor9BlsMfrPkZvi_nr9C5ePt7eTyfLOGeUt3GmBeeYKyk4SK24yIQiisjcZBlTWhpGKBhjNGCdZFonBZMcLOEiAW1ZQsfoYvjb-Pq7s6FNKxdyW5Z6ZesupIRxAhgDsJ5eDjT3dQjeFmnjXaX9Two4_Qst3YbW27P12y6rrNnKTUo9OB3Al_Yf1m_B9v783_Xs-WEQaWMK-gvNaHlT</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Teo, Cheryl Wei Ling</creator><creator>Tay, Shawn Han Yueh</creator><creator>Tey, Hong Liang</creator><creator>Ung, Yee Wei</creator><creator>Yap, Wei Ney</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2021</creationdate><title>Vitamin E in Atopic Dermatitis: From Preclinical to Clinical Studies</title><author>Teo, Cheryl Wei Ling ; Tay, Shawn Han Yueh ; Tey, Hong Liang ; Ung, Yee Wei ; Yap, Wei Ney</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-ba65505986518a956b692928cdbb49a8d4231ddda10a7baa7f4851e25671ae473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Atopic Dermatitis – Review Article</topic><topic>Dermatitis, Atopic - blood</topic><topic>Dermatitis, Atopic - drug therapy</topic><topic>Humans</topic><topic>Oxidative Stress - drug effects</topic><topic>Skin Physiological Phenomena - drug effects</topic><topic>Vitamin E - blood</topic><topic>Vitamin E - pharmacology</topic><topic>Vitamin E - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teo, Cheryl Wei Ling</creatorcontrib><creatorcontrib>Tay, Shawn Han Yueh</creatorcontrib><creatorcontrib>Tey, Hong Liang</creatorcontrib><creatorcontrib>Ung, Yee Wei</creatorcontrib><creatorcontrib>Yap, Wei Ney</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatology (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teo, Cheryl Wei Ling</au><au>Tay, Shawn Han Yueh</au><au>Tey, Hong Liang</au><au>Ung, Yee Wei</au><au>Yap, Wei Ney</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin E in Atopic Dermatitis: From Preclinical to Clinical Studies</atitle><jtitle>Dermatology (Basel)</jtitle><addtitle>Dermatology</addtitle><date>2021</date><risdate>2021</risdate><volume>237</volume><issue>4</issue><spage>553</spage><epage>564</epage><pages>553-564</pages><issn>1018-8665</issn><eissn>1421-9832</eissn><abstract>Background: Oxidative stress and inflammation are some of the proposed mechanisms involved in the pathogenesis of atopic dermatitis (AD). Current pharmacotherapeutic approaches are effective yet they are not without adverse effects. Vitamin E has great potential as an adjunctive treatment for AD owing to its antioxidant and anti-inflammatory bioactivities. Summary: This review article summarizes the current available evidence from cellular, animal and clinical studies on the relationship between vitamin E and AD. The future prospects of vitamin E are also discussed. Vitamin E in practice does not show any toxicity to humans within a range of reasonable dosage. Albeit rarely, vitamin E as a contact allergen should be considered. Collectively, this review envisaged vitamin E as an adjunctive treatment for AD patients. Future research on the distinct effects of different vitamin E isoforms as well as their delivery system in skin disorders is needed.</abstract><cop>Basel, Switzerland</cop><pmid>33070130</pmid><doi>10.1159/000510653</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Karger Journals |
| subjects | Animals Antioxidants - pharmacology Antioxidants - therapeutic use Atopic Dermatitis – Review Article Dermatitis, Atopic - blood Dermatitis, Atopic - drug therapy Humans Oxidative Stress - drug effects Skin Physiological Phenomena - drug effects Vitamin E - blood Vitamin E - pharmacology Vitamin E - therapeutic use |
| title | Vitamin E in Atopic Dermatitis: From Preclinical to Clinical Studies |
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