Palisaded Neutrophilic and Granulomatous Dermatitis in a Patient with Granulomatosis with Polyangiitis
Palisaded neutrophilic and granulomatous dermatitis (PNGD) shows various clinical features and is histologically characterized by palisaded granulomas surrounding degenerated collagen. PNGD is known to be associated with a variety of systemic conditions such as rheumatoid arthritis and systemic lupu...
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| Veröffentlicht in: | Case Reports in Dermatology 2020-01, Vol.12 (1), p.52-56 |
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| creator | Akagawa, Mai Hattori, Yuki Mizutani, Yoko Shu, En Miyazaki, Tatsuhiko Seishima, Mariko |
| description | Palisaded neutrophilic and granulomatous dermatitis (PNGD) shows various clinical features and is histologically characterized by palisaded granulomas surrounding degenerated collagen. PNGD is known to be associated with a variety of systemic conditions such as rheumatoid arthritis and systemic lupus erythematosus. Furthermore, PNGD has been reported to be associated with antineutrophilic cytoplasmic antibody-associated vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis. Here, we report a case of PNGD associated with GPA, which showed the infiltration of CD163-positive M2 macrophages in the skin lesion with elevated serum level of soluble CD163 (sCD163). The serum sCD163 level was reduced to normal range after systemic steroid therapy. Thus, M2 macrophages may play a role in the pathomechanisms of PNGD associated with GPA. |
| doi_str_mv | 10.1159/000506670 |
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PNGD is known to be associated with a variety of systemic conditions such as rheumatoid arthritis and systemic lupus erythematosus. Furthermore, PNGD has been reported to be associated with antineutrophilic cytoplasmic antibody-associated vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis. Here, we report a case of PNGD associated with GPA, which showed the infiltration of CD163-positive M2 macrophages in the skin lesion with elevated serum level of soluble CD163 (sCD163). The serum sCD163 level was reduced to normal range after systemic steroid therapy. Thus, M2 macrophages may play a role in the pathomechanisms of PNGD associated with GPA.</description><identifier>ISSN: 1662-6567</identifier><identifier>EISSN: 1662-6567</identifier><identifier>DOI: 10.1159/000506670</identifier><identifier>PMID: 32308576</identifier><language>eng</language><publisher>Basel, Switzerland: S. 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PNGD is known to be associated with a variety of systemic conditions such as rheumatoid arthritis and systemic lupus erythematosus. Furthermore, PNGD has been reported to be associated with antineutrophilic cytoplasmic antibody-associated vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis. Here, we report a case of PNGD associated with GPA, which showed the infiltration of CD163-positive M2 macrophages in the skin lesion with elevated serum level of soluble CD163 (sCD163). The serum sCD163 level was reduced to normal range after systemic steroid therapy. Thus, M2 macrophages may play a role in the pathomechanisms of PNGD associated with GPA.</description><subject>Antibodies</subject><subject>Biomarkers</subject><subject>Care and treatment</subject><subject>Case reports</subject><subject>Case studies</subject><subject>cd163</subject><subject>Collagen</subject><subject>Complications and side effects</subject><subject>Dermatitis</subject><subject>Development and progression</subject><subject>Disease</subject><subject>Granulomas</subject><subject>Granulomatosis with polyangiitis</subject><subject>Inflammatory diseases</subject><subject>Lupus</subject><subject>m2 macrophage</subject><subject>Neutrophils</subject><subject>palisaded neutrophilic and granulomatous dermatitis</subject><subject>Patients</subject><subject>pr3-anca</subject><subject>Rheumatoid arthritis</subject><subject>Single Case</subject><subject>Vein & artery diseases</subject><issn>1662-6567</issn><issn>1662-6567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DOA</sourceid><recordid>eNptkktr3DAUhU1paR7tovtSDFllMakelmRtCmHyaCC0s0jWQpauPJp6rKlkt-TfR4lTM4GihaR7v3M4F25RfMLoDGMmvyKEGOJcoDfFIeacLDjj4u3e-6A4SmmDEJeM0_fFASUU1Uzww8KtdOeTtmDLHzAOMezWvvOm1L0tr6Puxy5s9RDGVF5AzC8_-FT6vtTlKn-gH8q_fljvoykDz7VV6B503_onyYfindNdgo8v93Fxf3V5t_y-uP15fbM8v10YxsiwqGlNrINGU2KYFTVrMAFXAa8rLWmd0xtsJWeApTS6AYYZwshQxAHVghB6XNxMvjbojdpFv9XxQQXt1XMhxFbpOHjTgWpqKq2rrNC2rrgASRE42QiBpKWC4Oz1bfLajc0WrMnDRt29Mn3d6f1ateGPEphVhIlscPJiEMPvEdKgNmGMfZ5fkQpLSnmOkKmziWp1TuV7F7KZycfC1pvQg_O5fs4prXjFUJUFp5PAxJBSBDdHwkg97YOa9yGzX_ZnmMl_C5CBzxPwS8cW4gzM-pP_tpcXlxOhdtbRR3EfxZo</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Akagawa, Mai</creator><creator>Hattori, Yuki</creator><creator>Mizutani, Yoko</creator><creator>Shu, En</creator><creator>Miyazaki, Tatsuhiko</creator><creator>Seishima, Mariko</creator><general>S. Karger AG</general><general>Karger Publishers</general><scope>M--</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200101</creationdate><title>Palisaded Neutrophilic and Granulomatous Dermatitis in a Patient with Granulomatosis with Polyangiitis</title><author>Akagawa, Mai ; Hattori, Yuki ; Mizutani, Yoko ; Shu, En ; Miyazaki, Tatsuhiko ; Seishima, Mariko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c552t-8382dfeba32c5d785b12ef4e684a938956c1d965e199cabe515010c306e087223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibodies</topic><topic>Biomarkers</topic><topic>Care and treatment</topic><topic>Case reports</topic><topic>Case studies</topic><topic>cd163</topic><topic>Collagen</topic><topic>Complications and side effects</topic><topic>Dermatitis</topic><topic>Development and progression</topic><topic>Disease</topic><topic>Granulomas</topic><topic>Granulomatosis with polyangiitis</topic><topic>Inflammatory diseases</topic><topic>Lupus</topic><topic>m2 macrophage</topic><topic>Neutrophils</topic><topic>palisaded neutrophilic and granulomatous dermatitis</topic><topic>Patients</topic><topic>pr3-anca</topic><topic>Rheumatoid arthritis</topic><topic>Single Case</topic><topic>Vein & artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akagawa, Mai</creatorcontrib><creatorcontrib>Hattori, Yuki</creatorcontrib><creatorcontrib>Mizutani, Yoko</creatorcontrib><creatorcontrib>Shu, En</creatorcontrib><creatorcontrib>Miyazaki, Tatsuhiko</creatorcontrib><creatorcontrib>Seishima, Mariko</creatorcontrib><collection>Karger Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Case Reports in Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akagawa, Mai</au><au>Hattori, Yuki</au><au>Mizutani, Yoko</au><au>Shu, En</au><au>Miyazaki, Tatsuhiko</au><au>Seishima, Mariko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Palisaded Neutrophilic and Granulomatous Dermatitis in a Patient with Granulomatosis with Polyangiitis</atitle><jtitle>Case Reports in Dermatology</jtitle><addtitle>Case Rep Dermatol</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>12</volume><issue>1</issue><spage>52</spage><epage>56</epage><pages>52-56</pages><issn>1662-6567</issn><eissn>1662-6567</eissn><abstract>Palisaded neutrophilic and granulomatous dermatitis (PNGD) shows various clinical features and is histologically characterized by palisaded granulomas surrounding degenerated collagen. PNGD is known to be associated with a variety of systemic conditions such as rheumatoid arthritis and systemic lupus erythematosus. Furthermore, PNGD has been reported to be associated with antineutrophilic cytoplasmic antibody-associated vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis. Here, we report a case of PNGD associated with GPA, which showed the infiltration of CD163-positive M2 macrophages in the skin lesion with elevated serum level of soluble CD163 (sCD163). The serum sCD163 level was reduced to normal range after systemic steroid therapy. Thus, M2 macrophages may play a role in the pathomechanisms of PNGD associated with GPA.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>32308576</pmid><doi>10.1159/000506670</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antibodies Biomarkers Care and treatment Case reports Case studies cd163 Collagen Complications and side effects Dermatitis Development and progression Disease Granulomas Granulomatosis with polyangiitis Inflammatory diseases Lupus m2 macrophage Neutrophils palisaded neutrophilic and granulomatous dermatitis Patients pr3-anca Rheumatoid arthritis Single Case Vein & artery diseases |
| title | Palisaded Neutrophilic and Granulomatous Dermatitis in a Patient with Granulomatosis with Polyangiitis |
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