Short-Term Outcome and MRI Changes in Three Adult Patients with Sickle Cell Disease and Aseptic Osteonecrosis after Treatment with Hyperbaric Oxygen Therapy: A Preliminary Report
Background: Musculoskeletal manifestations are common in sickle cell disease (SCD). Vaso-occlusive crisis can manifest acutely as joint and bone pain, osteomyelitis and/or arthritis. It can also lead to chronic bone aches, bone deformities, degenerative arthritis, pathological fractures, and osteopo...
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| Veröffentlicht in: | Case Reports in Oncology 2020-01, Vol.13 (1), p.365-372 |
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| container_title | Case Reports in Oncology |
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| creator | Shier, Amr Abdelrazek, Mohamed Soliman, Ashraf De Sanctis, Vincenzo Elsayed, Ahmed Abdulla, Mohamed Mohamed, Shehab Yassin, Khadra Bilal, Ilham Yassin, Mohamed |
| description | Background: Musculoskeletal manifestations are common in sickle cell disease (SCD). Vaso-occlusive crisis can manifest acutely as joint and bone pain, osteomyelitis and/or arthritis. It can also lead to chronic bone aches, bone deformities, degenerative arthritis, pathological fractures, and osteoporosis. Hyperbaric oxygen (HBO) therapy is a mode of treatment in which the patient is exposed to very high arterial and tissue oxygen pressure, during multiple sessions. It has been used as primary or adjunctive therapy for a variety of medical disorders, including necrotizing infection and sickle cell crisis. Case Report: In this case series, 3 patients with SCD and avascular necrosis were treated with 15–40 sessions of HBO and were assessed 6–12 months by MRI after treatment. They showed different clinical outcomes and MRI changes. Conclusion: We concluded that HBO can result in some subjective improvement, especially in early stages. Further studies on severe cases are needed. |
| doi_str_mv | 10.1159/000506330 |
| format | Article |
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Vaso-occlusive crisis can manifest acutely as joint and bone pain, osteomyelitis and/or arthritis. It can also lead to chronic bone aches, bone deformities, degenerative arthritis, pathological fractures, and osteoporosis. Hyperbaric oxygen (HBO) therapy is a mode of treatment in which the patient is exposed to very high arterial and tissue oxygen pressure, during multiple sessions. It has been used as primary or adjunctive therapy for a variety of medical disorders, including necrotizing infection and sickle cell crisis. Case Report: In this case series, 3 patients with SCD and avascular necrosis were treated with 15–40 sessions of HBO and were assessed 6–12 months by MRI after treatment. They showed different clinical outcomes and MRI changes. Conclusion: We concluded that HBO can result in some subjective improvement, especially in early stages. Further studies on severe cases are needed.</description><identifier>ISSN: 1662-6575</identifier><identifier>EISSN: 1662-6575</identifier><identifier>DOI: 10.1159/000506330</identifier><identifier>PMID: 32355491</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>avascular necrosis of bone ; Care and treatment ; Case Report ; Case reports ; Case studies ; hyperbaric oxygen ; Hyperbaric oxygenation ; Ischemia ; Joint surgery ; Magnetic resonance imaging ; Osteonecrosis ; Oxygen therapy ; Pain ; Patient outcomes ; Patients ; Prostheses ; Quality of life ; Sickle cell anemia ; Sickle cell disease</subject><ispartof>Case Reports in Oncology, 2020-01, Vol.13 (1), p.365-372</ispartof><rights>2020 The Author(s). Published by S. Karger AG, Basel</rights><rights>Copyright © 2020 by S. Karger AG, Basel.</rights><rights>COPYRIGHT 2020 S. Karger AG</rights><rights>Copyright © 2020 by S. Karger AG, Basel 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-4a88b631621eb39366dacc6999fd79ce7b4b7e7fd8ca1ace3373b70d06b798313</citedby><cites>FETCH-LOGICAL-c552t-4a88b631621eb39366dacc6999fd79ce7b4b7e7fd8ca1ace3373b70d06b798313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184821/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184821/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27635,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32355491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shier, Amr</creatorcontrib><creatorcontrib>Abdelrazek, Mohamed</creatorcontrib><creatorcontrib>Soliman, Ashraf</creatorcontrib><creatorcontrib>De Sanctis, Vincenzo</creatorcontrib><creatorcontrib>Elsayed, Ahmed</creatorcontrib><creatorcontrib>Abdulla, Mohamed</creatorcontrib><creatorcontrib>Mohamed, Shehab</creatorcontrib><creatorcontrib>Yassin, Khadra</creatorcontrib><creatorcontrib>Bilal, Ilham</creatorcontrib><creatorcontrib>Yassin, Mohamed</creatorcontrib><title>Short-Term Outcome and MRI Changes in Three Adult Patients with Sickle Cell Disease and Aseptic Osteonecrosis after Treatment with Hyperbaric Oxygen Therapy: A Preliminary Report</title><title>Case Reports in Oncology</title><addtitle>Case Rep Oncol</addtitle><description>Background: Musculoskeletal manifestations are common in sickle cell disease (SCD). Vaso-occlusive crisis can manifest acutely as joint and bone pain, osteomyelitis and/or arthritis. It can also lead to chronic bone aches, bone deformities, degenerative arthritis, pathological fractures, and osteoporosis. Hyperbaric oxygen (HBO) therapy is a mode of treatment in which the patient is exposed to very high arterial and tissue oxygen pressure, during multiple sessions. It has been used as primary or adjunctive therapy for a variety of medical disorders, including necrotizing infection and sickle cell crisis. Case Report: In this case series, 3 patients with SCD and avascular necrosis were treated with 15–40 sessions of HBO and were assessed 6–12 months by MRI after treatment. They showed different clinical outcomes and MRI changes. Conclusion: We concluded that HBO can result in some subjective improvement, especially in early stages. Further studies on severe cases are needed.</description><subject>avascular necrosis of bone</subject><subject>Care and treatment</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Case studies</subject><subject>hyperbaric oxygen</subject><subject>Hyperbaric oxygenation</subject><subject>Ischemia</subject><subject>Joint surgery</subject><subject>Magnetic resonance imaging</subject><subject>Osteonecrosis</subject><subject>Oxygen therapy</subject><subject>Pain</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Prostheses</subject><subject>Quality of life</subject><subject>Sickle cell anemia</subject><subject>Sickle cell disease</subject><issn>1662-6575</issn><issn>1662-6575</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DOA</sourceid><recordid>eNptkk2PEyEcxidG467Vg3djSDx56DoMAwweNmnqyzZZ0023ngkD_2npzptA1X4tP6GMU-tuYjhA4OHH84QnSV7i9AJjKt6laUpTRkj6KDnHjGVTRjl9fG99ljzzfpemTFBGnyZnJCOU5gKfJ79ut50L0zW4Bi33QXcNINUa9GW1QPOtajfgkW3ReusA0Mzs64BuVLDQBo9-2LBFt1bf1YDmUNfog_Wg_AiYeeiD1WjpA3QtaNd565GqAji0dqBCExkj4urQgyuVG9Q_DxsYngOn-sN7NEM3Dmrb2Fa5A1pBH80-T55Uqvbw4jhPkq-fPq7nV9Pr5efFfHY91ZRmYZqroigZwSzDUBJBGDNKayaEqAwXGniZlxx4ZQqtsNJACCclT03KSi4KgskkWYxc06md7J1togfZKSv_bHRuI5WLEWuQjLJMY83jNZUrzAUvWGFEROOsNCVE1uXI6vdlA0bH7E7VD6APT1q7lZvuu-S4yItsMPPmCHDdtz34IHfd3rUxv8xyLIaYWR5VF6Nqo6Ir21ZdhOk4DDRWx2-obNyfxarkjA6VmSRvxwvD_3gH1ckSTuXQLXnqVtS-vp_hpPxbpn8e75TbgDsJ5qvliJC9qaLq1X9Vx1d-A3ym4F4</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Shier, Amr</creator><creator>Abdelrazek, Mohamed</creator><creator>Soliman, Ashraf</creator><creator>De Sanctis, Vincenzo</creator><creator>Elsayed, Ahmed</creator><creator>Abdulla, Mohamed</creator><creator>Mohamed, Shehab</creator><creator>Yassin, Khadra</creator><creator>Bilal, Ilham</creator><creator>Yassin, Mohamed</creator><general>S. Karger AG</general><general>Karger Publishers</general><scope>M--</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200101</creationdate><title>Short-Term Outcome and MRI Changes in Three Adult Patients with Sickle Cell Disease and Aseptic Osteonecrosis after Treatment with Hyperbaric Oxygen Therapy: A Preliminary Report</title><author>Shier, Amr ; Abdelrazek, Mohamed ; Soliman, Ashraf ; De Sanctis, Vincenzo ; Elsayed, Ahmed ; Abdulla, Mohamed ; Mohamed, Shehab ; Yassin, Khadra ; Bilal, Ilham ; Yassin, Mohamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c552t-4a88b631621eb39366dacc6999fd79ce7b4b7e7fd8ca1ace3373b70d06b798313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>avascular necrosis of bone</topic><topic>Care and treatment</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Case studies</topic><topic>hyperbaric oxygen</topic><topic>Hyperbaric oxygenation</topic><topic>Ischemia</topic><topic>Joint surgery</topic><topic>Magnetic resonance imaging</topic><topic>Osteonecrosis</topic><topic>Oxygen therapy</topic><topic>Pain</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Prostheses</topic><topic>Quality of life</topic><topic>Sickle cell anemia</topic><topic>Sickle cell disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shier, Amr</creatorcontrib><creatorcontrib>Abdelrazek, Mohamed</creatorcontrib><creatorcontrib>Soliman, Ashraf</creatorcontrib><creatorcontrib>De Sanctis, Vincenzo</creatorcontrib><creatorcontrib>Elsayed, Ahmed</creatorcontrib><creatorcontrib>Abdulla, Mohamed</creatorcontrib><creatorcontrib>Mohamed, Shehab</creatorcontrib><creatorcontrib>Yassin, Khadra</creatorcontrib><creatorcontrib>Bilal, Ilham</creatorcontrib><creatorcontrib>Yassin, Mohamed</creatorcontrib><collection>Karger Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Case Reports in Oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shier, Amr</au><au>Abdelrazek, Mohamed</au><au>Soliman, Ashraf</au><au>De Sanctis, Vincenzo</au><au>Elsayed, Ahmed</au><au>Abdulla, Mohamed</au><au>Mohamed, Shehab</au><au>Yassin, Khadra</au><au>Bilal, Ilham</au><au>Yassin, Mohamed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short-Term Outcome and MRI Changes in Three Adult Patients with Sickle Cell Disease and Aseptic Osteonecrosis after Treatment with Hyperbaric Oxygen Therapy: A Preliminary Report</atitle><jtitle>Case Reports in Oncology</jtitle><addtitle>Case Rep Oncol</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>13</volume><issue>1</issue><spage>365</spage><epage>372</epage><pages>365-372</pages><issn>1662-6575</issn><eissn>1662-6575</eissn><abstract>Background: Musculoskeletal manifestations are common in sickle cell disease (SCD). Vaso-occlusive crisis can manifest acutely as joint and bone pain, osteomyelitis and/or arthritis. It can also lead to chronic bone aches, bone deformities, degenerative arthritis, pathological fractures, and osteoporosis. Hyperbaric oxygen (HBO) therapy is a mode of treatment in which the patient is exposed to very high arterial and tissue oxygen pressure, during multiple sessions. It has been used as primary or adjunctive therapy for a variety of medical disorders, including necrotizing infection and sickle cell crisis. Case Report: In this case series, 3 patients with SCD and avascular necrosis were treated with 15–40 sessions of HBO and were assessed 6–12 months by MRI after treatment. They showed different clinical outcomes and MRI changes. Conclusion: We concluded that HBO can result in some subjective improvement, especially in early stages. Further studies on severe cases are needed.</abstract><cop>Basel, Switzerland</cop><pub>S. 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| subjects | avascular necrosis of bone Care and treatment Case Report Case reports Case studies hyperbaric oxygen Hyperbaric oxygenation Ischemia Joint surgery Magnetic resonance imaging Osteonecrosis Oxygen therapy Pain Patient outcomes Patients Prostheses Quality of life Sickle cell anemia Sickle cell disease |
| title | Short-Term Outcome and MRI Changes in Three Adult Patients with Sickle Cell Disease and Aseptic Osteonecrosis after Treatment with Hyperbaric Oxygen Therapy: A Preliminary Report |
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