Magnetic Hyperthermia Using Self-Controlled Heating Elements Consisting of Fe-Al Milling Alloy Induces Cancer Cell Apoptosis while Preserving Skeletal Muscle
Necrosis-inducing anticancer drugs enhance high-mobility group box 1 (HMGB1) release during cell necrosis, and HMGB1-induced autophagy in skeletal muscle induces muscle atrophy. We evaluated the efficacy of magnetic hyperthermia therapy (MHT) using a low-energy magnetic field and self-controlled hea...
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| Veröffentlicht in: | Pathobiology (Basel) 2019, Vol.86 (5-6), p.254-262 |
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| creator | Kawahara, Isao Goto, Kei Kodama, Kenji Luo, Yi Fujiwara-Tani, Rina Mori, Takuya Miyagawa, Yoshihiro Tanaka, Hirokazu Kodama, Hiroyuki Hosoito, Nobuyoshi Taniguchi, Yukinori Kuniyasu, Hiroki |
| description | Necrosis-inducing anticancer drugs enhance high-mobility group box 1 (HMGB1) release during cell necrosis, and HMGB1-induced autophagy in skeletal muscle induces muscle atrophy. We evaluated the efficacy of magnetic hyperthermia therapy (MHT) using a low-energy magnetic field and self-controlled heating elements in tumor treatment. MHT-induced apoptosis by heating mouse subcutaneous tumors at 43°C using a heat-controlling iron-aluminum (Fe-Al) milling alloy. In contrast, MHT using Fe line-induced necrosis by heating to approximately 100°C. Furthermore, MHT with Fe-Al milling alloy reduced stemness. In hyperthermia using age line or Fe-Al milling alloy, both of them provided histological degeneration in skeletal muscle; however, qualitative differences were observed. MHT using Fe-line induced pronounced autophagy, decrease of myosin heavy chain content, and increase in serum HMGB1. In contrast, MHT using Fe-Al milling alloy induced heat shock protein 90 but no autophagy and decreased serum HMGB1. Therefore, MHT using Fe-Al milling alloy might be a good method for local treatment of tumors to reduce skeletal muscle atrophy. |
| doi_str_mv | 10.1159/000501524 |
| format | Article |
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We evaluated the efficacy of magnetic hyperthermia therapy (MHT) using a low-energy magnetic field and self-controlled heating elements in tumor treatment. MHT-induced apoptosis by heating mouse subcutaneous tumors at 43°C using a heat-controlling iron-aluminum (Fe-Al) milling alloy. In contrast, MHT using Fe line-induced necrosis by heating to approximately 100°C. Furthermore, MHT with Fe-Al milling alloy reduced stemness. In hyperthermia using age line or Fe-Al milling alloy, both of them provided histological degeneration in skeletal muscle; however, qualitative differences were observed. MHT using Fe-line induced pronounced autophagy, decrease of myosin heavy chain content, and increase in serum HMGB1. In contrast, MHT using Fe-Al milling alloy induced heat shock protein 90 but no autophagy and decreased serum HMGB1. Therefore, MHT using Fe-Al milling alloy might be a good method for local treatment of tumors to reduce skeletal muscle atrophy.</description><identifier>ISSN: 1015-2008</identifier><identifier>EISSN: 1423-0291</identifier><identifier>DOI: 10.1159/000501524</identifier><identifier>PMID: 31722347</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Alloys ; Aluminum - chemistry ; Animals ; Apoptosis ; Autophagy ; Hyperthermia, Induced - instrumentation ; Hyperthermia, Induced - methods ; Iron - chemistry ; Magnetic Phenomena ; Male ; Mice ; Mice, Inbred BALB C ; Muscle, Skeletal - pathology ; Muscular Atrophy - pathology ; Necrosis ; Original Paper</subject><ispartof>Pathobiology (Basel), 2019, Vol.86 (5-6), p.254-262</ispartof><rights>2019 S. Karger AG, Basel</rights><rights>2019 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-e798f115870e48e77cce4e7af86c4f38c6ad3627dc4ddb9c15303570b7dbd2af3</citedby><cites>FETCH-LOGICAL-c407t-e798f115870e48e77cce4e7af86c4f38c6ad3627dc4ddb9c15303570b7dbd2af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31722347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawahara, Isao</creatorcontrib><creatorcontrib>Goto, Kei</creatorcontrib><creatorcontrib>Kodama, Kenji</creatorcontrib><creatorcontrib>Luo, Yi</creatorcontrib><creatorcontrib>Fujiwara-Tani, Rina</creatorcontrib><creatorcontrib>Mori, Takuya</creatorcontrib><creatorcontrib>Miyagawa, Yoshihiro</creatorcontrib><creatorcontrib>Tanaka, Hirokazu</creatorcontrib><creatorcontrib>Kodama, Hiroyuki</creatorcontrib><creatorcontrib>Hosoito, Nobuyoshi</creatorcontrib><creatorcontrib>Taniguchi, Yukinori</creatorcontrib><creatorcontrib>Kuniyasu, Hiroki</creatorcontrib><title>Magnetic Hyperthermia Using Self-Controlled Heating Elements Consisting of Fe-Al Milling Alloy Induces Cancer Cell Apoptosis while Preserving Skeletal Muscle</title><title>Pathobiology (Basel)</title><addtitle>Pathobiology</addtitle><description>Necrosis-inducing anticancer drugs enhance high-mobility group box 1 (HMGB1) release during cell necrosis, and HMGB1-induced autophagy in skeletal muscle induces muscle atrophy. We evaluated the efficacy of magnetic hyperthermia therapy (MHT) using a low-energy magnetic field and self-controlled heating elements in tumor treatment. MHT-induced apoptosis by heating mouse subcutaneous tumors at 43°C using a heat-controlling iron-aluminum (Fe-Al) milling alloy. In contrast, MHT using Fe line-induced necrosis by heating to approximately 100°C. Furthermore, MHT with Fe-Al milling alloy reduced stemness. In hyperthermia using age line or Fe-Al milling alloy, both of them provided histological degeneration in skeletal muscle; however, qualitative differences were observed. MHT using Fe-line induced pronounced autophagy, decrease of myosin heavy chain content, and increase in serum HMGB1. In contrast, MHT using Fe-Al milling alloy induced heat shock protein 90 but no autophagy and decreased serum HMGB1. Therefore, MHT using Fe-Al milling alloy might be a good method for local treatment of tumors to reduce skeletal muscle atrophy.</description><subject>Alloys</subject><subject>Aluminum - chemistry</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Autophagy</subject><subject>Hyperthermia, Induced - instrumentation</subject><subject>Hyperthermia, Induced - methods</subject><subject>Iron - chemistry</subject><subject>Magnetic Phenomena</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscular Atrophy - pathology</subject><subject>Necrosis</subject><subject>Original Paper</subject><issn>1015-2008</issn><issn>1423-0291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU1v2zAMhoViQ5t-HHYfBh3Xg1d92bKPQZA0BVq0QNuzoUh06kW2PElekR-z_1qlyXIi8fLhS4JE6BslvyjNqxtCSE5ozsQJmlDBeEZYRb-kPIkZI6Q8Q-ch_E5YSQpyis44lYxxISfo34Na9xBbjZfbAXx8A9-1Cr-Gtl_jZ7BNNnN99M5aMHgJKu70uYUO-hhwqoU2fGquwQvIphY_tNbuhKm1bovvejNqSKTqNXg8A2vxdHBDdKkRv7-1FvCThwD-7-fEDViIKrmMQVu4RF8bZQNcHeIFel3MX2bL7P7x9m42vc-0IDJmIKuySZcoJQFRgpRagwCpmrLQouGlLpThBZNGC2NWlaY5JzyXZCXNyjDV8Av0c-87ePdnhBDrrg067ap6cGOoGaciL0pSFQm93qPauxA8NPXg2075bU1JvftGffxGYn8cbMdVB-ZI_j9_Ar7vgY3ya_BH4ND_AVa3j8s</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Kawahara, Isao</creator><creator>Goto, Kei</creator><creator>Kodama, Kenji</creator><creator>Luo, Yi</creator><creator>Fujiwara-Tani, Rina</creator><creator>Mori, Takuya</creator><creator>Miyagawa, Yoshihiro</creator><creator>Tanaka, Hirokazu</creator><creator>Kodama, Hiroyuki</creator><creator>Hosoito, Nobuyoshi</creator><creator>Taniguchi, Yukinori</creator><creator>Kuniyasu, Hiroki</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2019</creationdate><title>Magnetic Hyperthermia Using Self-Controlled Heating Elements Consisting of Fe-Al Milling Alloy Induces Cancer Cell Apoptosis while Preserving Skeletal Muscle</title><author>Kawahara, Isao ; Goto, Kei ; Kodama, Kenji ; Luo, Yi ; Fujiwara-Tani, Rina ; Mori, Takuya ; Miyagawa, Yoshihiro ; Tanaka, Hirokazu ; Kodama, Hiroyuki ; Hosoito, Nobuyoshi ; Taniguchi, Yukinori ; Kuniyasu, Hiroki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-e798f115870e48e77cce4e7af86c4f38c6ad3627dc4ddb9c15303570b7dbd2af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alloys</topic><topic>Aluminum - chemistry</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Autophagy</topic><topic>Hyperthermia, Induced - instrumentation</topic><topic>Hyperthermia, Induced - methods</topic><topic>Iron - chemistry</topic><topic>Magnetic Phenomena</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscular Atrophy - pathology</topic><topic>Necrosis</topic><topic>Original Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawahara, Isao</creatorcontrib><creatorcontrib>Goto, Kei</creatorcontrib><creatorcontrib>Kodama, Kenji</creatorcontrib><creatorcontrib>Luo, Yi</creatorcontrib><creatorcontrib>Fujiwara-Tani, Rina</creatorcontrib><creatorcontrib>Mori, Takuya</creatorcontrib><creatorcontrib>Miyagawa, Yoshihiro</creatorcontrib><creatorcontrib>Tanaka, Hirokazu</creatorcontrib><creatorcontrib>Kodama, Hiroyuki</creatorcontrib><creatorcontrib>Hosoito, Nobuyoshi</creatorcontrib><creatorcontrib>Taniguchi, Yukinori</creatorcontrib><creatorcontrib>Kuniyasu, Hiroki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathobiology (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawahara, Isao</au><au>Goto, Kei</au><au>Kodama, Kenji</au><au>Luo, Yi</au><au>Fujiwara-Tani, Rina</au><au>Mori, Takuya</au><au>Miyagawa, Yoshihiro</au><au>Tanaka, Hirokazu</au><au>Kodama, Hiroyuki</au><au>Hosoito, Nobuyoshi</au><au>Taniguchi, Yukinori</au><au>Kuniyasu, Hiroki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic Hyperthermia Using Self-Controlled Heating Elements Consisting of Fe-Al Milling Alloy Induces Cancer Cell Apoptosis while Preserving Skeletal Muscle</atitle><jtitle>Pathobiology (Basel)</jtitle><addtitle>Pathobiology</addtitle><date>2019</date><risdate>2019</risdate><volume>86</volume><issue>5-6</issue><spage>254</spage><epage>262</epage><pages>254-262</pages><issn>1015-2008</issn><eissn>1423-0291</eissn><abstract>Necrosis-inducing anticancer drugs enhance high-mobility group box 1 (HMGB1) release during cell necrosis, and HMGB1-induced autophagy in skeletal muscle induces muscle atrophy. We evaluated the efficacy of magnetic hyperthermia therapy (MHT) using a low-energy magnetic field and self-controlled heating elements in tumor treatment. MHT-induced apoptosis by heating mouse subcutaneous tumors at 43°C using a heat-controlling iron-aluminum (Fe-Al) milling alloy. In contrast, MHT using Fe line-induced necrosis by heating to approximately 100°C. Furthermore, MHT with Fe-Al milling alloy reduced stemness. In hyperthermia using age line or Fe-Al milling alloy, both of them provided histological degeneration in skeletal muscle; however, qualitative differences were observed. MHT using Fe-line induced pronounced autophagy, decrease of myosin heavy chain content, and increase in serum HMGB1. In contrast, MHT using Fe-Al milling alloy induced heat shock protein 90 but no autophagy and decreased serum HMGB1. Therefore, MHT using Fe-Al milling alloy might be a good method for local treatment of tumors to reduce skeletal muscle atrophy.</abstract><cop>Basel, Switzerland</cop><pmid>31722347</pmid><doi>10.1159/000501524</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alloys Aluminum - chemistry Animals Apoptosis Autophagy Hyperthermia, Induced - instrumentation Hyperthermia, Induced - methods Iron - chemistry Magnetic Phenomena Male Mice Mice, Inbred BALB C Muscle, Skeletal - pathology Muscular Atrophy - pathology Necrosis Original Paper |
| title | Magnetic Hyperthermia Using Self-Controlled Heating Elements Consisting of Fe-Al Milling Alloy Induces Cancer Cell Apoptosis while Preserving Skeletal Muscle |
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