Insulin resistance in type 2 diabetic Nigerians
Background: Considerable interest has been generated and still continues on the role of insulin resistance in the aetiology of glucose intolerance and its complications. There is evidence to suggest that racial factors are important in this regard. Whereas Caucasian studies suggest insulin resistanc...
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| Veröffentlicht in: | Dubai diabetes and endocrinology journal 2019-03, Vol.13 (1), p.24-27 |
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| container_title | Dubai diabetes and endocrinology journal |
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| creator | Bakari, Adamu G. Onyemelukwe, Geoffrey C. |
| description | Background: Considerable interest has been generated and still continues on the role of insulin resistance in the aetiology of glucose intolerance and its complications. There is evidence to suggest that racial factors are important in this regard. Whereas Caucasian studies suggest insulin resistance to be universal in type-2 diabetes, African-American studies on the other hand suggest the contrary in a significant proportion of type-2 diabetic African-Americans. No previous study has been undertaken in this aspect in type-2 diabetic Nigerians. Objective: To measure insulin resistance using the Homeostasis Model Assessment (HOMA) among type-2 diabetic Nigerians. Subjects and methods: A cross sectional study involving 40 type-2 diabetic subjects and 36 controls. The HOMA method was used to compute insulin resistance for each subject. Individual HOMA scores were subjected to statistical analysis between the two (diabetic and non-diabetic) groups. Results: Forty type 2 diabetic patients and 36 healthy age and socio-economic status matched control subjects were studied. Mean HOMA scores were significantly higher among type 2 diabetic subjects than controls. Ten (27.8%) of the control subjects demonstrated HOMA insulin resistance values greater than one compared to 35 (87.5%) of type-2 diabetic patients (p |
| doi_str_mv | 10.1159/000497570 |
| format | Article |
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There is evidence to suggest that racial factors are important in this regard. Whereas Caucasian studies suggest insulin resistance to be universal in type-2 diabetes, African-American studies on the other hand suggest the contrary in a significant proportion of type-2 diabetic African-Americans. No previous study has been undertaken in this aspect in type-2 diabetic Nigerians. Objective: To measure insulin resistance using the Homeostasis Model Assessment (HOMA) among type-2 diabetic Nigerians. Subjects and methods: A cross sectional study involving 40 type-2 diabetic subjects and 36 controls. The HOMA method was used to compute insulin resistance for each subject. Individual HOMA scores were subjected to statistical analysis between the two (diabetic and non-diabetic) groups. Results: Forty type 2 diabetic patients and 36 healthy age and socio-economic status matched control subjects were studied. Mean HOMA scores were significantly higher among type 2 diabetic subjects than controls. Ten (27.8%) of the control subjects demonstrated HOMA insulin resistance values greater than one compared to 35 (87.5%) of type-2 diabetic patients (p<0.05). Conclusion: It is concluded although type-2 diabetic patients exhibit more insulin resistance than control subjects, insulin sensitive variants of type-2 diabetes is also found in this population.</description><identifier>ISSN: 2673-1797</identifier><identifier>ISSN: 1606-7754</identifier><identifier>EISSN: 2673-1738</identifier><identifier>EISSN: 2073-5944</identifier><identifier>DOI: 10.1159/000497570</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Further Section</subject><ispartof>Dubai diabetes and endocrinology journal, 2019-03, Vol.13 (1), p.24-27</ispartof><rights>2019 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c260t-bb73f014281c00259ba18023e0899f7d553abdda94a00fc288c49ebaa819ba473</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Bakari, Adamu G.</creatorcontrib><creatorcontrib>Onyemelukwe, Geoffrey C.</creatorcontrib><title>Insulin resistance in type 2 diabetic Nigerians</title><title>Dubai diabetes and endocrinology journal</title><addtitle>Dubai Diabetes Endocrinol J</addtitle><description>Background: Considerable interest has been generated and still continues on the role of insulin resistance in the aetiology of glucose intolerance and its complications. There is evidence to suggest that racial factors are important in this regard. Whereas Caucasian studies suggest insulin resistance to be universal in type-2 diabetes, African-American studies on the other hand suggest the contrary in a significant proportion of type-2 diabetic African-Americans. No previous study has been undertaken in this aspect in type-2 diabetic Nigerians. Objective: To measure insulin resistance using the Homeostasis Model Assessment (HOMA) among type-2 diabetic Nigerians. Subjects and methods: A cross sectional study involving 40 type-2 diabetic subjects and 36 controls. The HOMA method was used to compute insulin resistance for each subject. Individual HOMA scores were subjected to statistical analysis between the two (diabetic and non-diabetic) groups. Results: Forty type 2 diabetic patients and 36 healthy age and socio-economic status matched control subjects were studied. Mean HOMA scores were significantly higher among type 2 diabetic subjects than controls. Ten (27.8%) of the control subjects demonstrated HOMA insulin resistance values greater than one compared to 35 (87.5%) of type-2 diabetic patients (p<0.05). Conclusion: It is concluded although type-2 diabetic patients exhibit more insulin resistance than control subjects, insulin sensitive variants of type-2 diabetes is also found in this population.</description><subject>Further Section</subject><issn>2673-1797</issn><issn>1606-7754</issn><issn>2673-1738</issn><issn>2073-5944</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNptzztPwzAQB3ALgURVOrAzWGJiCD0_UtsjKq-gChaYo_MLWZQQ2WHotycoKBPT3en_0-mOkHMG14zVZg0A0qhawRFZ8I0SFVNCH8-9UadkVUqyILVRIxYLsm668r1PHc2hpDJg5wIdp-HQB8qpT2jDkBx9Tu8hJ-zKGTmJuC9h9VeX5O3-7nX7WO1eHprtza5yfANDZa0SEZjkmjkAXhuLTAMXAbQxUfm6Fmi9RyMRIDqutZMmWETNRiqVWJKraa_LX6XkENs-p0_Mh5ZB-_tsOz872ovJfmAez5zlHF_-GzdPt5Noex_FD0FdWkY</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Bakari, Adamu G.</creator><creator>Onyemelukwe, Geoffrey C.</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20190301</creationdate><title>Insulin resistance in type 2 diabetic Nigerians</title><author>Bakari, Adamu G. ; Onyemelukwe, Geoffrey C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c260t-bb73f014281c00259ba18023e0899f7d553abdda94a00fc288c49ebaa819ba473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Further Section</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bakari, Adamu G.</creatorcontrib><creatorcontrib>Onyemelukwe, Geoffrey C.</creatorcontrib><collection>CrossRef</collection><jtitle>Dubai diabetes and endocrinology journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bakari, Adamu G.</au><au>Onyemelukwe, Geoffrey C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin resistance in type 2 diabetic Nigerians</atitle><jtitle>Dubai diabetes and endocrinology journal</jtitle><addtitle>Dubai Diabetes Endocrinol J</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>13</volume><issue>1</issue><spage>24</spage><epage>27</epage><pages>24-27</pages><issn>2673-1797</issn><issn>1606-7754</issn><eissn>2673-1738</eissn><eissn>2073-5944</eissn><abstract>Background: Considerable interest has been generated and still continues on the role of insulin resistance in the aetiology of glucose intolerance and its complications. There is evidence to suggest that racial factors are important in this regard. Whereas Caucasian studies suggest insulin resistance to be universal in type-2 diabetes, African-American studies on the other hand suggest the contrary in a significant proportion of type-2 diabetic African-Americans. No previous study has been undertaken in this aspect in type-2 diabetic Nigerians. Objective: To measure insulin resistance using the Homeostasis Model Assessment (HOMA) among type-2 diabetic Nigerians. Subjects and methods: A cross sectional study involving 40 type-2 diabetic subjects and 36 controls. The HOMA method was used to compute insulin resistance for each subject. Individual HOMA scores were subjected to statistical analysis between the two (diabetic and non-diabetic) groups. Results: Forty type 2 diabetic patients and 36 healthy age and socio-economic status matched control subjects were studied. Mean HOMA scores were significantly higher among type 2 diabetic subjects than controls. Ten (27.8%) of the control subjects demonstrated HOMA insulin resistance values greater than one compared to 35 (87.5%) of type-2 diabetic patients (p<0.05). Conclusion: It is concluded although type-2 diabetic patients exhibit more insulin resistance than control subjects, insulin sensitive variants of type-2 diabetes is also found in this population.</abstract><cop>Basel, Switzerland</cop><doi>10.1159/000497570</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 2673-1797 |
| ispartof | Dubai diabetes and endocrinology journal, 2019-03, Vol.13 (1), p.24-27 |
| issn | 2673-1797 1606-7754 2673-1738 2073-5944 |
| language | eng |
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| source | DOAJ Directory of Open Access Journals; Karger Open Access Journals; Alma/SFX Local Collection |
| subjects | Further Section |
| title | Insulin resistance in type 2 diabetic Nigerians |
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