Effects of an Oral CRTh2 Antagonist (AZD1981) on Eosinophil Activity and Symptoms in Chronic Spontaneous Urticaria

Background: Approximately 50% of patients with chronic spontaneous urticaria (CSU) experience symptoms that are not fully controlled by antihistamines, indicating an unmet clinical need. Objective: To evaluate the effects of the selective CRTh2 antagonist AZD1981 on symptoms and targeted leukocytes...

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Veröffentlicht in:	International archives of allergy and immunology 2019-01, Vol.179 (1), p.21-30
Hauptverfasser:	Oliver, Eric Tyrell, Chichester, Kris, Devine, Kelly, Sterba, Patricia Meghan, Wegner, Craig, Vonakis, Becky Marie, Saini, Sarbjit Singh
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - administration & dosage Acetates - adverse effects Acetates - therapeutic use Administration, Oral Adult Aged Antagonists (Biochemistry) Chronic Disease Clinical Allergy – Research Article Development and progression Drug therapy Eosinophils Eosinophils - drug effects Eosinophils - physiology Female Hives (Disease) Humans Indoles - administration & dosage Indoles - adverse effects Indoles - therapeutic use Male Middle Aged Observations Patient outcomes Prostaglandin D2 - pharmacology Receptors, Immunologic - analysis Receptors, Immunologic - antagonists & inhibitors Receptors, Prostaglandin - analysis Receptors, Prostaglandin - antagonists & inhibitors Urticaria - drug therapy Urticaria - immunology
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