miR-142-5p Improves Neural Differentiation and Proliferation of Adipose-Derived Stem Cells

Background/Aims: MiRNAs may regulate neurogenic differentiation of adipose-derived stem cells (ADSCs). In this study, we hypothesized that the miR-142-5p can repress the expression of RhoA/ROCK1 pathway on the neurogenesis of ADSCs. Methods: Deregulated miRNA during neurogenic differentiation of ADS...

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Veröffentlicht in:	Cellular physiology and biochemistry 2018-01, Vol.50 (6), p.2097-2107
Hauptverfasser:	Yang, Liang, Wang, Zhi-Fei, Wu, Hao, Wang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - cytology Adipose-derived stem cells Alzheimer's disease Antagomirs - metabolism Cell culture Cell cycle Cell Differentiation Cell Line Cell Proliferation Gene expression Growth factors Humans Kinases MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism miR-142-5p Neurogenic differentiation Neurons - cytology Neurons - metabolism Original Paper Plasmids rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - genetics rho-Associated Kinases - metabolism RhoA rhoA GTP-Binding Protein - antagonists & inhibitors rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism RNA Interference RNA, Small Interfering - metabolism ROCK1 Signal Transduction Stem cells Stem Cells - cytology Stem Cells - metabolism Tubulin - metabolism
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