Autoimmunity-Associated PTPN22 Polymorphisms in Latent Autoimmune Diabetes of the Adult Differ from Those of Type 1 Diabetes Patients

Background: A portion of adults with humoral immune changes have clinical diabetes that is initially not insulin-requiring (latent autoimmune diabetes of the adult, LADA). One of the genes strongly associated with autoimmune diabetes is PTPN22. We hypothesized that the manifestation and clinical fea...

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Veröffentlicht in:	International archives of allergy and immunology 2018-01, Vol.177 (1), p.57-68
Hauptverfasser:	Heneberg, Petr, Kocková, Lucie, Čecháková, Marie, Daňková, Pavlína, Černá, Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alleles Autoantibodies - blood Autoantibodies - immunology Biomarkers Clinical Immunology – Research Article Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 2 Diagnosis, Differential Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Latent Autoimmune Diabetes in Adults - diagnosis Latent Autoimmune Diabetes in Adults - genetics Latent Autoimmune Diabetes in Adults - immunology Male Middle Aged Odds Ratio Phenotype Polymorphism, Genetic Polymorphism, Single Nucleotide Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics
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