Iodine-Induced Fetal Hypothyroidism: Diagnosis and Treatment with Intra-Amniotic Levothyroxine
Background: Iodine is necessary for fetal thyroid development. Excess maternal intake of iodine can cause fetal hypothyroidism due to the inability to escape from the Wolff-Chaikoff effect in utero. Case Report: We report a case of fetal hypothyroid goiter secondary to inadvertent excess maternal io...
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| Veröffentlicht in: | Hormone research in paediatrics 2018-01, Vol.90 (6), p.419-423 |
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| container_title | Hormone research in paediatrics |
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| creator | Hardley, Macy T. Chon, Andrew H. Mestman, Jorge Nguyen, Caroline T. Geffner, Mitchell E. Chmait, Ramen H. |
| description | Background: Iodine is necessary for fetal thyroid development. Excess maternal intake of iodine can cause fetal hypothyroidism due to the inability to escape from the Wolff-Chaikoff effect in utero. Case Report: We report a case of fetal hypothyroid goiter secondary to inadvertent excess maternal iodine ingestion from infertility supplements. The fetus was successfully treated with intra-amniotic levothyroxine injections. Serial fetal blood sampling confirmed fetal escape from the Wolff-Chaikoff effect in the mid third trimester. Early hearing test and neurodevelopmental milestones were normal. Conclusion: Intra-amniotic treatment of fetal hypothyroidism may decrease the rate of impaired neurodevelopment and sensorineural hearing loss. |
| doi_str_mv | 10.1159/000488776 |
| format | Article |
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Excess maternal intake of iodine can cause fetal hypothyroidism due to the inability to escape from the Wolff-Chaikoff effect in utero. Case Report: We report a case of fetal hypothyroid goiter secondary to inadvertent excess maternal iodine ingestion from infertility supplements. The fetus was successfully treated with intra-amniotic levothyroxine injections. Serial fetal blood sampling confirmed fetal escape from the Wolff-Chaikoff effect in the mid third trimester. Early hearing test and neurodevelopmental milestones were normal. Conclusion: Intra-amniotic treatment of fetal hypothyroidism may decrease the rate of impaired neurodevelopment and sensorineural hearing loss.</description><identifier>ISSN: 1663-2818</identifier><identifier>EISSN: 1663-2826</identifier><identifier>DOI: 10.1159/000488776</identifier><identifier>PMID: 29791909</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Adult ; Congenital Hypothyroidism - blood ; Congenital Hypothyroidism - chemically induced ; Congenital Hypothyroidism - diagnosis ; Congenital Hypothyroidism - drug therapy ; Female ; Fetal Diseases - blood ; Fetal Diseases - chemically induced ; Fetal Diseases - diagnosis ; Fetal Diseases - drug therapy ; Goiter - blood ; Goiter - chemically induced ; Goiter - diagnosis ; Goiter - drug therapy ; Humans ; Iodine - administration & dosage ; Iodine - adverse effects ; Male ; Novel Insights from Clinical Practice ; Pregnancy ; Prenatal Diagnosis ; Thyroxine - administration & dosage</subject><ispartof>Hormone research in paediatrics, 2018-01, Vol.90 (6), p.419-423</ispartof><rights>2018 S. Karger AG, Basel</rights><rights>2018 S. 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Excess maternal intake of iodine can cause fetal hypothyroidism due to the inability to escape from the Wolff-Chaikoff effect in utero. Case Report: We report a case of fetal hypothyroid goiter secondary to inadvertent excess maternal iodine ingestion from infertility supplements. The fetus was successfully treated with intra-amniotic levothyroxine injections. Serial fetal blood sampling confirmed fetal escape from the Wolff-Chaikoff effect in the mid third trimester. Early hearing test and neurodevelopmental milestones were normal. Conclusion: Intra-amniotic treatment of fetal hypothyroidism may decrease the rate of impaired neurodevelopment and sensorineural hearing loss.</description><subject>Adult</subject><subject>Congenital Hypothyroidism - blood</subject><subject>Congenital Hypothyroidism - chemically induced</subject><subject>Congenital Hypothyroidism - diagnosis</subject><subject>Congenital Hypothyroidism - drug therapy</subject><subject>Female</subject><subject>Fetal Diseases - blood</subject><subject>Fetal Diseases - chemically induced</subject><subject>Fetal Diseases - diagnosis</subject><subject>Fetal Diseases - drug therapy</subject><subject>Goiter - blood</subject><subject>Goiter - chemically induced</subject><subject>Goiter - diagnosis</subject><subject>Goiter - drug therapy</subject><subject>Humans</subject><subject>Iodine - administration & dosage</subject><subject>Iodine - adverse effects</subject><subject>Male</subject><subject>Novel Insights from Clinical Practice</subject><subject>Pregnancy</subject><subject>Prenatal Diagnosis</subject><subject>Thyroxine - administration & dosage</subject><issn>1663-2818</issn><issn>1663-2826</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0DtPwzAUBWALgWhVOrAjZImJIWAnjR9sVaE0UiUQKiuRE9-0huYh2wX67wlKycTkO3z3XPkgdE7JDaWxvCWETITgnB2hIWUsCkIRsuN-pmKAxs69t4xEgkvKT9EglO0giRyit6TWpoIgqfQuB43n4NUWL_ZN7Td7WxttXHmH741aV7UzDqtK45UF5UuoPP4yfoOTylsVTMvK1N7keAmf3e53m3uGTgq1dTA-vCP0On9YzRbB8ukxmU2XQR5FzAcqliETjOqwKKRgOmZZzrWIKYRikqmsAM5FqNpfqhiAaFJkjHAQKtYsF4RHI3Td5ea2ds5CkTbWlMruU0rS35rSvqbWXna22WUl6F7-ldKCqw58KLsG24PFy3MXkTa6aNXFv-pw5Qchi3h4</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Hardley, Macy T.</creator><creator>Chon, Andrew H.</creator><creator>Mestman, Jorge</creator><creator>Nguyen, Caroline T.</creator><creator>Geffner, Mitchell E.</creator><creator>Chmait, Ramen H.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-0384-3287</orcidid></search><sort><creationdate>20180101</creationdate><title>Iodine-Induced Fetal Hypothyroidism: Diagnosis and Treatment with Intra-Amniotic Levothyroxine</title><author>Hardley, Macy T. ; Chon, Andrew H. ; Mestman, Jorge ; Nguyen, Caroline T. ; Geffner, Mitchell E. ; Chmait, Ramen H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-a5926861d2ff986d56bc7d851e284babfe7782a877a5ee0d0fb607e8a5d6c8073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Congenital Hypothyroidism - blood</topic><topic>Congenital Hypothyroidism - chemically induced</topic><topic>Congenital Hypothyroidism - diagnosis</topic><topic>Congenital Hypothyroidism - drug therapy</topic><topic>Female</topic><topic>Fetal Diseases - blood</topic><topic>Fetal Diseases - chemically induced</topic><topic>Fetal Diseases - diagnosis</topic><topic>Fetal Diseases - drug therapy</topic><topic>Goiter - blood</topic><topic>Goiter - chemically induced</topic><topic>Goiter - diagnosis</topic><topic>Goiter - drug therapy</topic><topic>Humans</topic><topic>Iodine - administration & dosage</topic><topic>Iodine - adverse effects</topic><topic>Male</topic><topic>Novel Insights from Clinical Practice</topic><topic>Pregnancy</topic><topic>Prenatal Diagnosis</topic><topic>Thyroxine - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hardley, Macy T.</creatorcontrib><creatorcontrib>Chon, Andrew H.</creatorcontrib><creatorcontrib>Mestman, Jorge</creatorcontrib><creatorcontrib>Nguyen, Caroline T.</creatorcontrib><creatorcontrib>Geffner, Mitchell E.</creatorcontrib><creatorcontrib>Chmait, Ramen H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Hormone research in paediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hardley, Macy T.</au><au>Chon, Andrew H.</au><au>Mestman, Jorge</au><au>Nguyen, Caroline T.</au><au>Geffner, Mitchell E.</au><au>Chmait, Ramen H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iodine-Induced Fetal Hypothyroidism: Diagnosis and Treatment with Intra-Amniotic Levothyroxine</atitle><jtitle>Hormone research in paediatrics</jtitle><addtitle>Horm Res Paediatr</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>90</volume><issue>6</issue><spage>419</spage><epage>423</epage><pages>419-423</pages><issn>1663-2818</issn><eissn>1663-2826</eissn><abstract>Background: Iodine is necessary for fetal thyroid development. Excess maternal intake of iodine can cause fetal hypothyroidism due to the inability to escape from the Wolff-Chaikoff effect in utero. Case Report: We report a case of fetal hypothyroid goiter secondary to inadvertent excess maternal iodine ingestion from infertility supplements. The fetus was successfully treated with intra-amniotic levothyroxine injections. Serial fetal blood sampling confirmed fetal escape from the Wolff-Chaikoff effect in the mid third trimester. Early hearing test and neurodevelopmental milestones were normal. Conclusion: Intra-amniotic treatment of fetal hypothyroidism may decrease the rate of impaired neurodevelopment and sensorineural hearing loss.</abstract><cop>Basel, Switzerland</cop><pmid>29791909</pmid><doi>10.1159/000488776</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-0384-3287</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Hormone research in paediatrics, 2018-01, Vol.90 (6), p.419-423 |
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| source | MEDLINE; Karger Journals; Alma/SFX Local Collection |
| subjects | Adult Congenital Hypothyroidism - blood Congenital Hypothyroidism - chemically induced Congenital Hypothyroidism - diagnosis Congenital Hypothyroidism - drug therapy Female Fetal Diseases - blood Fetal Diseases - chemically induced Fetal Diseases - diagnosis Fetal Diseases - drug therapy Goiter - blood Goiter - chemically induced Goiter - diagnosis Goiter - drug therapy Humans Iodine - administration & dosage Iodine - adverse effects Male Novel Insights from Clinical Practice Pregnancy Prenatal Diagnosis Thyroxine - administration & dosage |
| title | Iodine-Induced Fetal Hypothyroidism: Diagnosis and Treatment with Intra-Amniotic Levothyroxine |
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