Cyclic Mechanical Stretch Induced Smooth Muscle Cell Changes in Cerebral Aneurysm Progress by Reducing Collagen Type IV and Collagen Type VI Levels

Background/Aims: Cerebral aneurysm growth is characterized by continuous structural weakness of local smooth muscle cells, though the mechanism is unclear. In this study, we examine protein changes in cerebral aneurysm and human brain vascular smooth muscle cells after cyclic mechanical stretch. We...

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Veröffentlicht in:	Cellular physiology and biochemistry 2018-01, Vol.45 (3), p.1051-1060
Hauptverfasser:	Liu, Peixi, Song, Yaying, Zhou, Yingjie, Liu, Yingjun, Qiu, Tianming, An, Qingzhu, Song, Jianping, Li, Peiliang, Shi, Yuan, Li, Sichen, Quan, Kai, Yang, Guo-Yuan, Zhu, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Aneurysms Apoptosis Cells, Cultured Cerebral aneurysm Chromatography, High Pressure Liquid Collagen Collagen Type IV - metabolism Collagen Type VI - metabolism Cyclic mechanical stretch Cytokines Down-Regulation Encyclopedias Gene expression Genomes Humans Intracranial Aneurysm - metabolism Intracranial Aneurysm - pathology Matrix Metalloproteinase 1 - metabolism Matrix Metalloproteinase 3 - metabolism Myocytes, Smooth Muscle Original Paper Peptides - analysis Protein expression Proteins Proteomics Smooth muscle Smooth muscle cells Statistical analysis Stress, Mechanical Stroke Tandem Mass Spectrometry Up-Regulation Variance analysis
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