Elbasvir/Grazoprevir, an Alternative in Antiviral Hepatitis C Therapy in Patients under Amiodarone Treatment
A sofosbuvir/ledipasvir combination is part of a first-line treatment of hepatitis C. However, in patients concurrently treated with amiodarone, cardiac side effects have been described, resulting in an official warning in 2015 by the American Food and Drug Administration and the European Medicines...
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| Veröffentlicht in: | Case Reports in Gastroenterology 2018-01, Vol.12 (1), p.92-98 |
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| container_title | Case Reports in Gastroenterology |
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| creator | Weiss, Lina Wustmann, Kerstin Semmo, Mariam Schwerzmann, Markus Semmo, Nasser |
| description | A sofosbuvir/ledipasvir combination is part of a first-line treatment of hepatitis C. However, in patients concurrently treated with amiodarone, cardiac side effects have been described, resulting in an official warning in 2015 by the American Food and Drug Administration and the European Medicines Agency when combining those substances. This deprived numerous hepatitis C patients with concurrent cardiovascular problems of receiving this highly effective treatment. Here we present a treatment alternative with an elbasvir/grazoprevir regimen, based on our successful treatment of a patient under concurrent amiodarone therapy. Our observations indicate that patients treated with amiodarone can finally benefit from effective antiviral therapy. |
| doi_str_mv | 10.1159/000486951 |
| format | Article |
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However, in patients concurrently treated with amiodarone, cardiac side effects have been described, resulting in an official warning in 2015 by the American Food and Drug Administration and the European Medicines Agency when combining those substances. This deprived numerous hepatitis C patients with concurrent cardiovascular problems of receiving this highly effective treatment. Here we present a treatment alternative with an elbasvir/grazoprevir regimen, based on our successful treatment of a patient under concurrent amiodarone therapy. Our observations indicate that patients treated with amiodarone can finally benefit from effective antiviral therapy.</description><identifier>ISSN: 1662-0631</identifier><identifier>EISSN: 1662-0631</identifier><identifier>DOI: 10.1159/000486951</identifier><identifier>PMID: 29606942</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Abdomen ; Amiodarone ; Antiviral agents ; Antiviral drugs ; Biopsy ; Cardiac arrhythmia ; Cardiac patients ; Cardiology ; Cardiovascular disease ; Care and treatment ; Case reports ; Drug interactions ; Drugs ; Gastroenterology ; Grazoprevir ; Heart rate ; Hepatitis ; Hepatitis C ; Hepatology ; Hypothyroidism ; Kidney diseases ; Laboratories ; Liver ; Patients ; Product safety ; Single Case ; Ultrasonic imaging</subject><ispartof>Case Reports in Gastroenterology, 2018-01, Vol.12 (1), p.92-98</ispartof><rights>2018 The Author(s). Published by S. Karger AG, Basel</rights><rights>COPYRIGHT 2018 S. Karger AG</rights><rights>Copyright © 2018 by S. Karger AG, Basel 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4931-e08371bc247090ad171c53f040b86bf8936bc13c571e9ff742f0d590135a0d263</citedby><cites>FETCH-LOGICAL-c4931-e08371bc247090ad171c53f040b86bf8936bc13c571e9ff742f0d590135a0d263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869552/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869552/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,27634,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29606942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weiss, Lina</creatorcontrib><creatorcontrib>Wustmann, Kerstin</creatorcontrib><creatorcontrib>Semmo, Mariam</creatorcontrib><creatorcontrib>Schwerzmann, Markus</creatorcontrib><creatorcontrib>Semmo, Nasser</creatorcontrib><title>Elbasvir/Grazoprevir, an Alternative in Antiviral Hepatitis C Therapy in Patients under Amiodarone Treatment</title><title>Case Reports in Gastroenterology</title><addtitle>Case Rep Gastroenterol</addtitle><description>A sofosbuvir/ledipasvir combination is part of a first-line treatment of hepatitis C. However, in patients concurrently treated with amiodarone, cardiac side effects have been described, resulting in an official warning in 2015 by the American Food and Drug Administration and the European Medicines Agency when combining those substances. This deprived numerous hepatitis C patients with concurrent cardiovascular problems of receiving this highly effective treatment. Here we present a treatment alternative with an elbasvir/grazoprevir regimen, based on our successful treatment of a patient under concurrent amiodarone therapy. Our observations indicate that patients treated with amiodarone can finally benefit from effective antiviral therapy.</description><subject>Abdomen</subject><subject>Amiodarone</subject><subject>Antiviral agents</subject><subject>Antiviral drugs</subject><subject>Biopsy</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac patients</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Case reports</subject><subject>Drug interactions</subject><subject>Drugs</subject><subject>Gastroenterology</subject><subject>Grazoprevir</subject><subject>Heart rate</subject><subject>Hepatitis</subject><subject>Hepatitis C</subject><subject>Hepatology</subject><subject>Hypothyroidism</subject><subject>Kidney diseases</subject><subject>Laboratories</subject><subject>Liver</subject><subject>Patients</subject><subject>Product safety</subject><subject>Single Case</subject><subject>Ultrasonic imaging</subject><issn>1662-0631</issn><issn>1662-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1r3DAQhk1padK0h95LMeRU6Cb6sGTrEliWdBMItJTtWcjSeKOtbbmSdyH99Z2tU5NA0UGjmWdeZkaTZe8puaBUqEtCSFFJJeiL7JRKyRZEcvryiX2SvUlpR4gsGKevsxOmJJGqYKdZe93WJh18vFxH8zsMEdD-nJs-X7YjxN6M_gC5x2ePlo-mzW9gQO_oU77KN_cQzfBwBL6hE_ox5fveQcyXnQ_OxNBDvolgxg5jb7NXjWkTvHu8z7IfX643q5vF3df17Wp5t7CF4nQBpOIlrS0rSqKIcbSkVvCGFKSuZN1UisvaUm5FSUE1TVmwhjihCOXCEMckP8tuJ10XzE4P0XcmPuhgvP7rCHGrTRy9bUErKYSpSs6gFIUFoawpma0dVcBoJR1qXU1aw77uwFlsA4fwTPR5pPf3ehsOWhx_RDAUOH8UiOHXHtKod2GPg22TZhRbU4oritTFRG0NVuX7JqCYxeOg8xan2Hj0L0VVKTzFMeHTlGBjSClCM5dEiT5uhZ63AtmPT3uYyX9rgMCHCfhp4hbiDMz55_8Nr76vJ0IPruF_AL5Wxoc</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Weiss, Lina</creator><creator>Wustmann, Kerstin</creator><creator>Semmo, Mariam</creator><creator>Schwerzmann, Markus</creator><creator>Semmo, Nasser</creator><general>S. Karger AG</general><general>Karger Publishers</general><scope>M--</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>201801</creationdate><title>Elbasvir/Grazoprevir, an Alternative in Antiviral Hepatitis C Therapy in Patients under Amiodarone Treatment</title><author>Weiss, Lina ; Wustmann, Kerstin ; Semmo, Mariam ; Schwerzmann, Markus ; Semmo, Nasser</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4931-e08371bc247090ad171c53f040b86bf8936bc13c571e9ff742f0d590135a0d263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abdomen</topic><topic>Amiodarone</topic><topic>Antiviral agents</topic><topic>Antiviral drugs</topic><topic>Biopsy</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac patients</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Care and treatment</topic><topic>Case reports</topic><topic>Drug interactions</topic><topic>Drugs</topic><topic>Gastroenterology</topic><topic>Grazoprevir</topic><topic>Heart rate</topic><topic>Hepatitis</topic><topic>Hepatitis C</topic><topic>Hepatology</topic><topic>Hypothyroidism</topic><topic>Kidney diseases</topic><topic>Laboratories</topic><topic>Liver</topic><topic>Patients</topic><topic>Product safety</topic><topic>Single Case</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weiss, Lina</creatorcontrib><creatorcontrib>Wustmann, Kerstin</creatorcontrib><creatorcontrib>Semmo, Mariam</creatorcontrib><creatorcontrib>Schwerzmann, Markus</creatorcontrib><creatorcontrib>Semmo, Nasser</creatorcontrib><collection>Karger Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Case Reports in Gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weiss, Lina</au><au>Wustmann, Kerstin</au><au>Semmo, Mariam</au><au>Schwerzmann, Markus</au><au>Semmo, Nasser</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elbasvir/Grazoprevir, an Alternative in Antiviral Hepatitis C Therapy in Patients under Amiodarone Treatment</atitle><jtitle>Case Reports in Gastroenterology</jtitle><addtitle>Case Rep Gastroenterol</addtitle><date>2018-01</date><risdate>2018</risdate><volume>12</volume><issue>1</issue><spage>92</spage><epage>98</epage><pages>92-98</pages><issn>1662-0631</issn><eissn>1662-0631</eissn><abstract>A sofosbuvir/ledipasvir combination is part of a first-line treatment of hepatitis C. 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| subjects | Abdomen Amiodarone Antiviral agents Antiviral drugs Biopsy Cardiac arrhythmia Cardiac patients Cardiology Cardiovascular disease Care and treatment Case reports Drug interactions Drugs Gastroenterology Grazoprevir Heart rate Hepatitis Hepatitis C Hepatology Hypothyroidism Kidney diseases Laboratories Liver Patients Product safety Single Case Ultrasonic imaging |
| title | Elbasvir/Grazoprevir, an Alternative in Antiviral Hepatitis C Therapy in Patients under Amiodarone Treatment |
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