Inhibition of the SOCS1-JAK2-STAT3 Signaling Pathway Confers Neuroprotection in Rats with Ischemic Stroke

The present study aims to investigate the protective effects of the SOCS1-JAK2-STAT3 signaling pathway on neurons in a rat model of ischemic stroke. Our study was conducted using an ischemic stroke rat model. After the microglia were extracted, 40 neonatal Sprague-Dawley (SD) rats were assigned into...

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Veröffentlicht in:	Cellular physiology and biochemistry 2017-01, Vol.44 (1), p.85-98
Hauptverfasser:	Wang, Xiao-Lei, Qiao, Chun-Mei, Liu, Jiong-Ou, Li, Chun-Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Caspase 3 - metabolism Disease Models, Animal Glutathione - analysis Ischemic stroke JAK2 Janus Kinase 2 - genetics Janus Kinase 2 - metabolism Male Malondialdehyde - analysis Neuron Neurons - pathology Neurons - ultrastructure Oxidative Stress - drug effects Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Rats, Sprague-Dawley Retracted Paper Signal Transduction - drug effects Signaling pathway SOCS1 STAT3 STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Stroke - metabolism Stroke - pathology Superoxide Dismutase - analysis Suppressor of Cytokine Signaling 1 Protein - genetics Suppressor of Cytokine Signaling 1 Protein - metabolism Tyrphostins - pharmacology
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