LncRNA UCA1 Promotes Mitochondrial Function of Bladder Cancer via the MiR-195/ARL2 Signaling Pathway

Background/Aims: This study aims to identify whether Urothelial Cancer Associated 1 (UCA1) regulates mitochondrial metabolic reprogramming in bladder cancer, and to explore how UCA1 participates in mitochondrial metabolism by the UCA1/miR-195/ARL2 signaling pathway; these findings may be aid in the...

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Veröffentlicht in:	Cellular physiology and biochemistry 2017-01, Vol.43 (6), p.2548-2561
Hauptverfasser:	Li, Hui-Jin, Sun, Xiao-Min, Li, Zheng-Kun, Yin, Qian-Wen, Pang, Huan, Pan, Jing-Jing, Li, Xu, Chen, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Adenosine Triphosphate - metabolism Aged Animal research Animals Antagomirs - metabolism Apoptosis ARL2 Base Sequence Bladder cancer Cell growth Cell Line, Tumor Cell Survival DNA, Mitochondrial - analysis DNA, Mitochondrial - metabolism Female GTP-Binding Proteins - antagonists & inhibitors GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Humans Laboratories LncRNA UCA1 Male Medical research Membrane Potential, Mitochondrial Metabolism Metastasis Mice Mice, Inbred BALB C Mice, Nude MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Middle Aged MiR-195 Mitochondria Mitochondria - genetics Mitochondria - metabolism Original Paper Plasmids RNA Interference RNA, Long Noncoding - antagonists & inhibitors RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Small Interfering - metabolism Sequence Alignment Signal Transduction Stem cells Transplantation, Heterologous Urinary Bladder - metabolism Urinary Bladder - pathology Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology
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