Aloe-Emodin Relieves High-Fat Diet Induced QT Prolongation via MiR-1 Inhibition and IK1 Up-Regulation in Rats

Background/Aims: High-fat diet (HFD) causes cardiac electrical remodeling and increases the risk of ventricular arrhythmias. Aloe-emodin (AE) is an anthraquinone component isolated from rhubarb and has a similar chemical structure with emodin. The protective effect of emodin against cardiac diseases...

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Veröffentlicht in:	Cellular physiology and biochemistry 2017, Vol.43 (5), p.1961-1973
Hauptverfasser:	Bai, Yan, Su, Zhenli, Sun, Hanqi, Zhao, Wei, Chen, Xue, Hang, Pengzhou, Zhu, Wenliang, Du, Zhimin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aloe-emodin Animals Anthraquinones - therapeutic use Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - metabolism Blotting, Western Cells, Cultured Diet, High-Fat - adverse effects Electrocardiography Heart Ventricles - cytology High-fat IK1 Male MicroRNAs - metabolism MiR-1 Muscle Cells - drug effects Muscle Cells - metabolism Original Paper Patch-Clamp Techniques QT interval Rats Real-Time Polymerase Chain Reaction
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