Biomarkers of Renal Injury in Cirrhosis: Association with Acute Kidney Injury and Recovery after Liver Transplantation
Background: To define urine or serum biomarkers in predicting renal function recovery after liver transplantation (LT). Methods: Adults listed for LT (February 2011-July 2014) and with modified diet for renal disease-6 (MDRD-6) 30, compared to MELD
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| Veröffentlicht in: | Nephron (2015) 2018-01, Vol.138 (1), p.1-12 |
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| container_title | Nephron (2015) |
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| creator | Singal, Ashwani K. Jackson, Bradford Pereira, Glauber B. Russ, Kirk B. Fitzmorris, Paul Stephen Kakati, Donny Axley, Page Ravi, Sujan Seay, Toni Ramachandra Rao, Satish P. Mehta, Ravindra Kuo, Yong-Fang Singh, Karan P. Agarwal, Anupam |
| description | Background: To define urine or serum biomarkers in predicting renal function recovery after liver transplantation (LT). Methods: Adults listed for LT (February 2011-July 2014) and with modified diet for renal disease-6 (MDRD-6) 30, compared to MELD |
| doi_str_mv | 10.1159/000479074 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1159_000479074</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1936262462</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-acf8acdd4187aa0f48ea17c19967c26c3ecafe39a002f2c45e44eddca0dd162d3</originalsourceid><addsrcrecordid>eNpVkU1vEzEURS1ERaPSBXuEvITFgL_GY7NAClFLKyIhobK2jP2mcTuxgz0TlH-PS9KoXVlPPu_YVxehN5R8pLTVnwghotOkEy_QjDHeNpwq-RLNqJSkUbSlp-i8lLuKMU655uIVOmVKdZx3fIa2X0Na23wPueDU458Q7YCv492UdzhEvAg5r1IJ5TOel5JcsGNIEf8N4wrP3TQC_h58hN3jio2-OlzawsPQj5DxMtQB32Qby2awcfxveI1OejsUOD-cZ-jX5cXN4qpZ_vh2vZgvG8e1HBvremWd94KqzlrSCwWWdo5qLTvHpOPgbA9c2xquZ060IAR47yzxnkrm-Rn6svdupt9r8A7imO1gNjnU0DuTbDDPb2JYmdu0Na1iSnekCt4fBDn9maCMZh2Kg6EmgTQVQzWXTDIhWUU_7FGXUykZ-uMzlJiHqsyxqsq-e_qvI_lYTAXe7oF7m28hH4HD_j9lrpr6</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1936262462</pqid></control><display><type>article</type><title>Biomarkers of Renal Injury in Cirrhosis: Association with Acute Kidney Injury and Recovery after Liver Transplantation</title><source>MEDLINE</source><source>Karger Journals</source><creator>Singal, Ashwani K. ; Jackson, Bradford ; Pereira, Glauber B. ; Russ, Kirk B. ; Fitzmorris, Paul Stephen ; Kakati, Donny ; Axley, Page ; Ravi, Sujan ; Seay, Toni ; Ramachandra Rao, Satish P. ; Mehta, Ravindra ; Kuo, Yong-Fang ; Singh, Karan P. ; Agarwal, Anupam</creator><creatorcontrib>Singal, Ashwani K. ; Jackson, Bradford ; Pereira, Glauber B. ; Russ, Kirk B. ; Fitzmorris, Paul Stephen ; Kakati, Donny ; Axley, Page ; Ravi, Sujan ; Seay, Toni ; Ramachandra Rao, Satish P. ; Mehta, Ravindra ; Kuo, Yong-Fang ; Singh, Karan P. ; Agarwal, Anupam</creatorcontrib><description>Background: To define urine or serum biomarkers in predicting renal function recovery after liver transplantation (LT). Methods: Adults listed for LT (February 2011-July 2014) and with modified diet for renal disease-6 (MDRD-6) <60 mL/min provided urine/blood samples at baseline and serially until LT for biomarkers in serum (pg/mL) and urine (pg/mg creatinine). Results: Of 271 LT listed patients (mean age 57 years, 63% males, median listing MELD 17.5), 1 year acute kidney injury (AKI) probability was 49%, with odds of 1.3-, 3.0-, 4.6-, and 8.5-fold times for listing MELD 16-20, 21-25, 26-30, and >30, compared to MELD <16. Thirty-seven people died over 1 year from the time of listing, with twofold increased odds with AKI. Among 67 patients with MDRD <60, only urinary epidermal growth factor was different comparing AKI (increase in serum creatinine ≥0.3 mg/dL from baseline within past 3 months) vs. no AKI (2,254 vs. 4,253, p = 0.003). Differences between acute tubular necrosis (ATN) and hepatorenal syndrome could not be ascertained for a small sample of 3 patients with ATN. Analyzing 15 of 43 receiving LT and MDRD-6 <30 prior to LT, biomarkers were not different comparing 5 patients recovering renal function (MDRD-6 >50 mL/min) at 6 months vs. 10 without recovery. Conclusions: AKI is common among LT listed patients, with a negative impact on transplant-free survival. Serum and urine biomarkers are not associated with the recovery of renal function after LT. Multicenter studies are suggested to (a) develop strategies to reduce the development of AKI and (b) derive novel biomarkers for use in accurately predicting renal recovery after LT.</description><identifier>ISSN: 1660-8151</identifier><identifier>EISSN: 2235-3186</identifier><identifier>DOI: 10.1159/000479074</identifier><identifier>PMID: 28873373</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Acute Kidney Injury - etiology ; Acute Kidney Injury - metabolism ; Adult ; Aged ; Biomarkers - analysis ; Clinical Practice: Original Paper ; Cohort Studies ; Diet ; Epidermal Growth Factor - urine ; Female ; Humans ; Kidney Function Tests ; Kidney Tubules - pathology ; Liver Cirrhosis - complications ; Liver Cirrhosis - metabolism ; Liver Cirrhosis - surgery ; Liver Transplantation ; Male ; Middle Aged ; Necrosis ; Predictive Value of Tests ; Recovery of Function ; Retrospective Studies ; Waiting Lists - mortality</subject><ispartof>Nephron (2015), 2018-01, Vol.138 (1), p.1-12</ispartof><rights>2017 S. Karger AG, Basel</rights><rights>2017 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-acf8acdd4187aa0f48ea17c19967c26c3ecafe39a002f2c45e44eddca0dd162d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,887,2431,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28873373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singal, Ashwani K.</creatorcontrib><creatorcontrib>Jackson, Bradford</creatorcontrib><creatorcontrib>Pereira, Glauber B.</creatorcontrib><creatorcontrib>Russ, Kirk B.</creatorcontrib><creatorcontrib>Fitzmorris, Paul Stephen</creatorcontrib><creatorcontrib>Kakati, Donny</creatorcontrib><creatorcontrib>Axley, Page</creatorcontrib><creatorcontrib>Ravi, Sujan</creatorcontrib><creatorcontrib>Seay, Toni</creatorcontrib><creatorcontrib>Ramachandra Rao, Satish P.</creatorcontrib><creatorcontrib>Mehta, Ravindra</creatorcontrib><creatorcontrib>Kuo, Yong-Fang</creatorcontrib><creatorcontrib>Singh, Karan P.</creatorcontrib><creatorcontrib>Agarwal, Anupam</creatorcontrib><title>Biomarkers of Renal Injury in Cirrhosis: Association with Acute Kidney Injury and Recovery after Liver Transplantation</title><title>Nephron (2015)</title><addtitle>Nephron</addtitle><description>Background: To define urine or serum biomarkers in predicting renal function recovery after liver transplantation (LT). Methods: Adults listed for LT (February 2011-July 2014) and with modified diet for renal disease-6 (MDRD-6) <60 mL/min provided urine/blood samples at baseline and serially until LT for biomarkers in serum (pg/mL) and urine (pg/mg creatinine). Results: Of 271 LT listed patients (mean age 57 years, 63% males, median listing MELD 17.5), 1 year acute kidney injury (AKI) probability was 49%, with odds of 1.3-, 3.0-, 4.6-, and 8.5-fold times for listing MELD 16-20, 21-25, 26-30, and >30, compared to MELD <16. Thirty-seven people died over 1 year from the time of listing, with twofold increased odds with AKI. Among 67 patients with MDRD <60, only urinary epidermal growth factor was different comparing AKI (increase in serum creatinine ≥0.3 mg/dL from baseline within past 3 months) vs. no AKI (2,254 vs. 4,253, p = 0.003). Differences between acute tubular necrosis (ATN) and hepatorenal syndrome could not be ascertained for a small sample of 3 patients with ATN. Analyzing 15 of 43 receiving LT and MDRD-6 <30 prior to LT, biomarkers were not different comparing 5 patients recovering renal function (MDRD-6 >50 mL/min) at 6 months vs. 10 without recovery. Conclusions: AKI is common among LT listed patients, with a negative impact on transplant-free survival. Serum and urine biomarkers are not associated with the recovery of renal function after LT. Multicenter studies are suggested to (a) develop strategies to reduce the development of AKI and (b) derive novel biomarkers for use in accurately predicting renal recovery after LT.</description><subject>Acute Kidney Injury - etiology</subject><subject>Acute Kidney Injury - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers - analysis</subject><subject>Clinical Practice: Original Paper</subject><subject>Cohort Studies</subject><subject>Diet</subject><subject>Epidermal Growth Factor - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney Function Tests</subject><subject>Kidney Tubules - pathology</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - metabolism</subject><subject>Liver Cirrhosis - surgery</subject><subject>Liver Transplantation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Necrosis</subject><subject>Predictive Value of Tests</subject><subject>Recovery of Function</subject><subject>Retrospective Studies</subject><subject>Waiting Lists - mortality</subject><issn>1660-8151</issn><issn>2235-3186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1vEzEURS1ERaPSBXuEvITFgL_GY7NAClFLKyIhobK2jP2mcTuxgz0TlH-PS9KoXVlPPu_YVxehN5R8pLTVnwghotOkEy_QjDHeNpwq-RLNqJSkUbSlp-i8lLuKMU655uIVOmVKdZx3fIa2X0Na23wPueDU458Q7YCv492UdzhEvAg5r1IJ5TOel5JcsGNIEf8N4wrP3TQC_h58hN3jio2-OlzawsPQj5DxMtQB32Qby2awcfxveI1OejsUOD-cZ-jX5cXN4qpZ_vh2vZgvG8e1HBvremWd94KqzlrSCwWWdo5qLTvHpOPgbA9c2xquZ060IAR47yzxnkrm-Rn6svdupt9r8A7imO1gNjnU0DuTbDDPb2JYmdu0Na1iSnekCt4fBDn9maCMZh2Kg6EmgTQVQzWXTDIhWUU_7FGXUykZ-uMzlJiHqsyxqsq-e_qvI_lYTAXe7oF7m28hH4HD_j9lrpr6</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Singal, Ashwani K.</creator><creator>Jackson, Bradford</creator><creator>Pereira, Glauber B.</creator><creator>Russ, Kirk B.</creator><creator>Fitzmorris, Paul Stephen</creator><creator>Kakati, Donny</creator><creator>Axley, Page</creator><creator>Ravi, Sujan</creator><creator>Seay, Toni</creator><creator>Ramachandra Rao, Satish P.</creator><creator>Mehta, Ravindra</creator><creator>Kuo, Yong-Fang</creator><creator>Singh, Karan P.</creator><creator>Agarwal, Anupam</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180101</creationdate><title>Biomarkers of Renal Injury in Cirrhosis: Association with Acute Kidney Injury and Recovery after Liver Transplantation</title><author>Singal, Ashwani K. ; Jackson, Bradford ; Pereira, Glauber B. ; Russ, Kirk B. ; Fitzmorris, Paul Stephen ; Kakati, Donny ; Axley, Page ; Ravi, Sujan ; Seay, Toni ; Ramachandra Rao, Satish P. ; Mehta, Ravindra ; Kuo, Yong-Fang ; Singh, Karan P. ; Agarwal, Anupam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-acf8acdd4187aa0f48ea17c19967c26c3ecafe39a002f2c45e44eddca0dd162d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acute Kidney Injury - etiology</topic><topic>Acute Kidney Injury - metabolism</topic><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers - analysis</topic><topic>Clinical Practice: Original Paper</topic><topic>Cohort Studies</topic><topic>Diet</topic><topic>Epidermal Growth Factor - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney Function Tests</topic><topic>Kidney Tubules - pathology</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver Cirrhosis - metabolism</topic><topic>Liver Cirrhosis - surgery</topic><topic>Liver Transplantation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Necrosis</topic><topic>Predictive Value of Tests</topic><topic>Recovery of Function</topic><topic>Retrospective Studies</topic><topic>Waiting Lists - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singal, Ashwani K.</creatorcontrib><creatorcontrib>Jackson, Bradford</creatorcontrib><creatorcontrib>Pereira, Glauber B.</creatorcontrib><creatorcontrib>Russ, Kirk B.</creatorcontrib><creatorcontrib>Fitzmorris, Paul Stephen</creatorcontrib><creatorcontrib>Kakati, Donny</creatorcontrib><creatorcontrib>Axley, Page</creatorcontrib><creatorcontrib>Ravi, Sujan</creatorcontrib><creatorcontrib>Seay, Toni</creatorcontrib><creatorcontrib>Ramachandra Rao, Satish P.</creatorcontrib><creatorcontrib>Mehta, Ravindra</creatorcontrib><creatorcontrib>Kuo, Yong-Fang</creatorcontrib><creatorcontrib>Singh, Karan P.</creatorcontrib><creatorcontrib>Agarwal, Anupam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nephron (2015)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singal, Ashwani K.</au><au>Jackson, Bradford</au><au>Pereira, Glauber B.</au><au>Russ, Kirk B.</au><au>Fitzmorris, Paul Stephen</au><au>Kakati, Donny</au><au>Axley, Page</au><au>Ravi, Sujan</au><au>Seay, Toni</au><au>Ramachandra Rao, Satish P.</au><au>Mehta, Ravindra</au><au>Kuo, Yong-Fang</au><au>Singh, Karan P.</au><au>Agarwal, Anupam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomarkers of Renal Injury in Cirrhosis: Association with Acute Kidney Injury and Recovery after Liver Transplantation</atitle><jtitle>Nephron (2015)</jtitle><addtitle>Nephron</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>138</volume><issue>1</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>1660-8151</issn><eissn>2235-3186</eissn><abstract>Background: To define urine or serum biomarkers in predicting renal function recovery after liver transplantation (LT). Methods: Adults listed for LT (February 2011-July 2014) and with modified diet for renal disease-6 (MDRD-6) <60 mL/min provided urine/blood samples at baseline and serially until LT for biomarkers in serum (pg/mL) and urine (pg/mg creatinine). Results: Of 271 LT listed patients (mean age 57 years, 63% males, median listing MELD 17.5), 1 year acute kidney injury (AKI) probability was 49%, with odds of 1.3-, 3.0-, 4.6-, and 8.5-fold times for listing MELD 16-20, 21-25, 26-30, and >30, compared to MELD <16. Thirty-seven people died over 1 year from the time of listing, with twofold increased odds with AKI. Among 67 patients with MDRD <60, only urinary epidermal growth factor was different comparing AKI (increase in serum creatinine ≥0.3 mg/dL from baseline within past 3 months) vs. no AKI (2,254 vs. 4,253, p = 0.003). Differences between acute tubular necrosis (ATN) and hepatorenal syndrome could not be ascertained for a small sample of 3 patients with ATN. Analyzing 15 of 43 receiving LT and MDRD-6 <30 prior to LT, biomarkers were not different comparing 5 patients recovering renal function (MDRD-6 >50 mL/min) at 6 months vs. 10 without recovery. Conclusions: AKI is common among LT listed patients, with a negative impact on transplant-free survival. Serum and urine biomarkers are not associated with the recovery of renal function after LT. Multicenter studies are suggested to (a) develop strategies to reduce the development of AKI and (b) derive novel biomarkers for use in accurately predicting renal recovery after LT.</abstract><cop>Basel, Switzerland</cop><pmid>28873373</pmid><doi>10.1159/000479074</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Kidney Injury - etiology Acute Kidney Injury - metabolism Adult Aged Biomarkers - analysis Clinical Practice: Original Paper Cohort Studies Diet Epidermal Growth Factor - urine Female Humans Kidney Function Tests Kidney Tubules - pathology Liver Cirrhosis - complications Liver Cirrhosis - metabolism Liver Cirrhosis - surgery Liver Transplantation Male Middle Aged Necrosis Predictive Value of Tests Recovery of Function Retrospective Studies Waiting Lists - mortality |
| title | Biomarkers of Renal Injury in Cirrhosis: Association with Acute Kidney Injury and Recovery after Liver Transplantation |
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