The Deubiquitinating Enzyme USP14 Regulates Leukemic Chemotherapy Drugs-Induced Cell Apoptosis by Suppressing Ubiquitination of Aurora Kinase B

Background/Aims: Aurora kinase B is a mitotic checkpoint kinase that plays a pivotal role in mitosis by ensuring correct chromosome segregation and normal progression through mitosis. Aurora B has been found to be amplified and overexpressed in several types of leukemia. The deubiquitinating enzyme...

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Veröffentlicht in:	Cellular physiology and biochemistry 2017-01, Vol.42 (3), p.965-973
Hauptverfasser:	Song, Chunge, Ma, Ruojin, Yang, Xiaoyu, Pang, Sulei
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Aurora B Aurora Kinase B - metabolism b-AP15 Cell Line, Tumor Deubiquitinating enzyme Humans Leukemia Leukemia - drug therapy Leukemia - metabolism Original Paper Proteolysis - drug effects Ubiquitin Thiolesterase - metabolism Ubiquitination - drug effects USP14
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