Fractional Exhaled Nitric Oxide: A Potential Biomarker in Allergic Rhinitis?
Background: The fractional concentration of exhaled nitric oxide (FeNO) is a surrogate biomarker for Th2-dependent bronchial inflammation. The present study investigated whether FeNO may characterize allergic rhinitis (AR) patients. Methods: A total of 553 AR patients (497 males, mean age 28.8 years...
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| Veröffentlicht in: | International archives of allergy and immunology 2017-03, Vol.172 (2), p.99-105 |
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| creator | Ciprandi, Giorgio Gallo, Fabio Ricciardolo, Fabio Luigi Massimo Cirillo, Ignazio |
| description | Background: The fractional concentration of exhaled nitric oxide (FeNO) is a surrogate biomarker for Th2-dependent bronchial inflammation. The present study investigated whether FeNO may characterize allergic rhinitis (AR) patients. Methods: A total of 553 AR patients (497 males, mean age 28.8 years) were evaluated. Those patients with a high FeNO underwent a 2-year follow-up. Results: Increased FeNO was associated with a significantly longer AR duration, impaired lung function, more severe symptoms, and more frequent bronchial hyperresponsiveness (BHR). At follow-up, 22 out of 82 patients (26.8%) with high FeNO levels (>50 ppb) developed asthma. Conclusions: AR patients may frequently have high FeNO values, exceeding 50 ppb. This might be associated with an initial impaired lung function, BHR, a perceived worsening of respiratory symptoms, and potential progression to asthma. |
| doi_str_mv | 10.1159/000456548 |
| format | Article |
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The present study investigated whether FeNO may characterize allergic rhinitis (AR) patients. Methods: A total of 553 AR patients (497 males, mean age 28.8 years) were evaluated. Those patients with a high FeNO underwent a 2-year follow-up. Results: Increased FeNO was associated with a significantly longer AR duration, impaired lung function, more severe symptoms, and more frequent bronchial hyperresponsiveness (BHR). At follow-up, 22 out of 82 patients (26.8%) with high FeNO levels (>50 ppb) developed asthma. Conclusions: AR patients may frequently have high FeNO values, exceeding 50 ppb. This might be associated with an initial impaired lung function, BHR, a perceived worsening of respiratory symptoms, and potential progression to asthma.</description><identifier>ISSN: 1018-2438</identifier><identifier>EISSN: 1423-0097</identifier><identifier>DOI: 10.1159/000456548</identifier><identifier>PMID: 28253520</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Allergic rhinitis ; Allergies ; Asthma ; Asthma - diagnosis ; Asthma - etiology ; Biomarkers ; Biomarkers - metabolism ; Breath Tests ; Bronchial Hyperreactivity - diagnosis ; Complications and side effects ; Development and progression ; Diagnosis ; Disease Progression ; Exhalation ; Female ; Follow-Up Studies ; Health aspects ; Humans ; Inflammation ; Lymphocytes T ; Male ; Molecules and Cells in Allergy - Original Paper ; Nitric oxide ; Nitric Oxide - metabolism ; Patients ; Respiratory diseases ; Respiratory Function Tests ; Rhinitis, Allergic - complications ; Rhinitis, Allergic - diagnosis ; Risk factors ; Young Adult</subject><ispartof>International archives of allergy and immunology, 2017-03, Vol.172 (2), p.99-105</ispartof><rights>2017 S. Karger AG, Basel</rights><rights>2017 S. Karger AG, Basel.</rights><rights>COPYRIGHT 2017 S. Karger AG</rights><rights>Copyright S. Karger AG Mar 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-84b9be00cee09def0e2362666991a4bb4b9784f304d04f619be4588ccded61723</citedby><cites>FETCH-LOGICAL-c365t-84b9be00cee09def0e2362666991a4bb4b9784f304d04f619be4588ccded61723</cites><orcidid>0000-0003-1826-5018</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28253520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ciprandi, Giorgio</creatorcontrib><creatorcontrib>Gallo, Fabio</creatorcontrib><creatorcontrib>Ricciardolo, Fabio Luigi Massimo</creatorcontrib><creatorcontrib>Cirillo, Ignazio</creatorcontrib><title>Fractional Exhaled Nitric Oxide: A Potential Biomarker in Allergic Rhinitis?</title><title>International archives of allergy and immunology</title><addtitle>Int Arch Allergy Immunol</addtitle><description>Background: The fractional concentration of exhaled nitric oxide (FeNO) is a surrogate biomarker for Th2-dependent bronchial inflammation. The present study investigated whether FeNO may characterize allergic rhinitis (AR) patients. Methods: A total of 553 AR patients (497 males, mean age 28.8 years) were evaluated. Those patients with a high FeNO underwent a 2-year follow-up. Results: Increased FeNO was associated with a significantly longer AR duration, impaired lung function, more severe symptoms, and more frequent bronchial hyperresponsiveness (BHR). At follow-up, 22 out of 82 patients (26.8%) with high FeNO levels (>50 ppb) developed asthma. Conclusions: AR patients may frequently have high FeNO values, exceeding 50 ppb. 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The present study investigated whether FeNO may characterize allergic rhinitis (AR) patients. Methods: A total of 553 AR patients (497 males, mean age 28.8 years) were evaluated. Those patients with a high FeNO underwent a 2-year follow-up. Results: Increased FeNO was associated with a significantly longer AR duration, impaired lung function, more severe symptoms, and more frequent bronchial hyperresponsiveness (BHR). At follow-up, 22 out of 82 patients (26.8%) with high FeNO levels (>50 ppb) developed asthma. Conclusions: AR patients may frequently have high FeNO values, exceeding 50 ppb. This might be associated with an initial impaired lung function, BHR, a perceived worsening of respiratory symptoms, and potential progression to asthma.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>28253520</pmid><doi>10.1159/000456548</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1826-5018</orcidid></addata></record> |
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| source | Karger电子期刊和电子书数据库; MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Allergic rhinitis Allergies Asthma Asthma - diagnosis Asthma - etiology Biomarkers Biomarkers - metabolism Breath Tests Bronchial Hyperreactivity - diagnosis Complications and side effects Development and progression Diagnosis Disease Progression Exhalation Female Follow-Up Studies Health aspects Humans Inflammation Lymphocytes T Male Molecules and Cells in Allergy - Original Paper Nitric oxide Nitric Oxide - metabolism Patients Respiratory diseases Respiratory Function Tests Rhinitis, Allergic - complications Rhinitis, Allergic - diagnosis Risk factors Young Adult |
| title | Fractional Exhaled Nitric Oxide: A Potential Biomarker in Allergic Rhinitis? |
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