Antiviral and Immunomodulatory Effects of Norantea brasiliensis Choisy on Dengue Virus-2

Background/Aims: Severe dengue fever is a result of exacerbated immune responses and no specific treatments are available. We evaluated the antiviral and immunomodulatory effects of Norantea brasiliensis Choisy. Methods: Human adherent monocytes infected in vitro with dengue virus (DENV)-2 were incu...

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Veröffentlicht in:	Intervirology 2016-01, Vol.59 (4), p.217-227
Hauptverfasser:	Fialho, Luciana Gomes, da Silva, Vagner Pereira, Reis, Sônia Regina Nogueira Ignácio, Azeredo, Elzinandes Leal, Kaplan, Maria Auxiliadora Coelho, Figueiredo, Maria Raquel, Kubelka, Claire Fernandes
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Viral - analysis Antigens, Viral - immunology Antiviral Agents - chemistry Antiviral Agents - pharmacology Cytokines - antagonists & inhibitors Cytokines - drug effects Cytokines - immunology Cytokines - secretion Dengue Virus - drug effects Dengue Virus - immunology Ethanol - chemistry Humans Immunomodulation - drug effects In Vitro Techniques Interleukin-10 - antagonists & inhibitors Interleukin-6 - antagonists & inhibitors Magnoliopsida - chemistry Monocytes - drug effects Monocytes - immunology Monocytes - virology Original Paper Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves - chemistry Plants, Medicinal - chemistry Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - drug effects Viral Load - drug effects Viral Nonstructural Proteins - drug effects
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