Adenovirus-Mediated Overexpression of Septin 2 Attenuates α-Smooth Muscle Actin Expression and Adventitial Myofibroblast Migration Induced by Angiotensin II

Phenotypic transformation from adventitial fibroblasts (AFs) to myofibroblasts (MFs) is critical for vascular remodeling. Septin 2 was found to be downregulated during the differentiation of AFs to MFs induced by angiotensin II (Ang II); however, the role of septin 2 in this process is still unknown...

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Veröffentlicht in:	Journal of vascular research 2016-01, Vol.53 (5-6), p.309-316
Hauptverfasser:	Guo, Shu-Jie, Zhang, Peng, Wu, Ling-Yun, Zhang, Guan-Nan, Chen, Wen-Dong, Gao, Ping-Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Actins - genetics Actins - metabolism Adenoviridae - genetics Adventitia - drug effects Adventitia - metabolism Angiotensin II - pharmacology Animals Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Cell Movement - drug effects Cells, Cultured Genetic Vectors Male Myofibroblasts - drug effects Myofibroblasts - metabolism Phenotype Protein Processing, Post-Translational Rats, Sprague-Dawley Research Paper rhoA GTP-Binding Protein - metabolism Septins - genetics Septins - metabolism Signal Transduction - drug effects Transfection - methods Tubulin - metabolism Up-Regulation
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