Non-IgE-Dependent Hypersensitivity to Rocuronium Reversed by Sugammadex: Report of Three Cases and Hypothesis on the Underlying Mechanism

We present 3 cases of pseudoallergic (anaphylactoid) reactions to perioperatively administered rocuronium, which rapidly resolved after sugammadex injection. Allergological workup showed no evidence for immediate-type hypersensitivity to the drugs used for anesthesia, including rocuronium. However,...

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Veröffentlicht in:	International archives of allergy and immunology 2016-01, Vol.169 (4), p.256-262
Hauptverfasser:	Spoerl, David, D''Incau, Stéphanie, Roux-Lombard, Pascale, Harr, Thomas, Czarnetzki, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Allergies Androstanols - adverse effects Anesthesia Case studies Complications and side effects Drug hypersensitivity Drug Hypersensitivity - diagnosis Drug Hypersensitivity - drug therapy Drug Hypersensitivity - etiology Drug therapy Female gamma-Cyclodextrins - therapeutic use Health aspects Humans Immunoglobulin E Male Middle Aged Neuromuscular Nondepolarizing Agents - adverse effects Novel Insights from Clinical Practice Phenotype Rocuronium bromide Skin Tests Sugammadex
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